Human brain nascent polypeptide-associated complex α subunit is decreased in patients with Alzheimer's disease and Down syndrome

Journal of Investigative Medicine

Volumn 50, Issue 4, 2002, Pages 293-301

  Kim, Seong Hwan ^a   Shim, Ki Shuk ^a   Lubec, Gert ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

Alzheimer's disease; Down syndrome; Nascent polypeptide associated complex; Neurodegenerative diseases; Transcription coactivator

Indexed keywords

ACTIN; ENOLASE; MESSENGER RNA; POLYPEPTIDE; PROTEIN SUBUNIT; STRESS ACTIVATED PROTEIN KINASE;

ADULT; AGED; ALPHA CHAIN; ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; BETA CHAIN; CONTROLLED STUDY; DEGENERATIVE DISEASE; DOWN REGULATION; DOWN SYNDROME; ENDOPLASMIC RETICULUM; FRONTAL CORTEX; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; PROTEIN DEGRADATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY;

EID: 0036305948     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: 10.2310/6650.2002.33287     Document Type: Article

References (35)

1. Protein biogenesis: Chaperones for nascent polypeptides
2. A protein complex required for signal-sequence-specific sorting and translocation
3. Nascent polypeptide-associated complex protein prevents mistargeting of nascent chains to the endoplasmic reticulum
4. The yeast nascent polypeptide-associated complex initiates protein targeting to mitochondria in vivo
5. Nascent polypeptide-associated complex stimulates protein import into yeast mitochondria
6. The nascent polypeptide-associated complex modulates interactions between the signal recognition particle and the ribosome
7. The α β subunit of the nascent polypeptide-associated complex have distinct functions
8. Genomic structure of the putative BTF3 transcription factor
9. Bone-specific expression of the a chain of the nascent polypeptide-associated complex, a coactivator potentiating c-Jun-mediated transcription
10. The α chain of the nascent polypeptide-associated complex functions as a transcriptional coactivator
11. Differential splicing-in of a proline-rich exon converts α-NAC into a muscle-specific transcription factor
12. Fission yeast nascent polypeptide-associated complex binds to four-way DNA junctions
13. The NINCDS-ADRDA Work Group criteria for the clinical diagnosis of probable Alzheimer's disease: A clinicopathologic study of 57 cases
14. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD): Part II - Standardization of the neuropathologic assessment of Alzheimer's disease
15. Alzheimer's disease brain: Alterations in RNA levels and in a ribonuclease-inhibitor complex
16. A correlation between gene transcriptional activity and cerebral glucose metabolism in Alzheimer's disease-affected neocortex: Cause or effect?
17. Neuronal RNA oxidation in Alzheimer's disease and Down's syndrome
18. Alzheimer's disease-associated reduction of polysomal mRNA translation
19. Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activation
20. Transcriptional coactivators in yeast and beyond
21. Stimulation of RNA polymerase II transcription initiation by recruitment of TBP in vivo
22. Increased immunoreactivity for Jun- and Fos-related proteins in Alzheimer's disease: Association with pathology
23. Differential induction of immediate early gene proteins in cultured neurons by β-amyloid (A β): Association of c-Jun with A β-induced apoptosis
24. DNA damage and apoptosis in Alzheimer's disease: Colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay
25. TAF(II)s mediate activation of transcription in the Drosophila embryo
26. An insertional mutation in the BTF3 transcription factor gene leads to an early postimplantation lethality in mice
27. Bicaudal encodes the Drosophila β-NAC homolog, a component of the ribosomal translational machinery
28. The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome
29. Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome
30. Initial characterization of the nascent polypeptide-associated complex in yeast
31. NAC covers ribosome-associated nascent chains thereby forming a protective environment for regions of nascent chains just emerging from the peptidyl transferase center
32. Heat-shock protein 70 levels in brain of patients with Down syndrome and Alzheimer's disease
33. Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice
34. Brain t-complex polypeptide 1 (TCP-1) related to its natural substrate β1 tubulin is decreased in Alzheimer's disease
35. The expression of several mitochondrial and nuclear genes encoding the subunits of electron transport chain enzyme complexes, cytochrome c oxidase, and NADH dehydrogenase, in different brain regions in Alzheimer's disease