Homozygous deletion on the chromosomal region 5q12.3 in human lines of small-cell lung cancers

Journal of Human Genetics

Volumn 47, Issue 7, 2002, Pages 348-354

  Tamura, Kenji ^a   Miwa, Wataru ^a   Maruyama, Tomoko ^a   Sekiya, Takao ^a   Murakami, Yoshinori ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

Alu repetitive sequence; Chromosome 5q; Homologous recombination; Homozygous deletion; Small cell lung cancer; Tumor suppressor gene

Indexed keywords

BACTERIAL DNA; BACTERIOPHAGE DNA; CELL DNA; DNA FRAGMENT; FUNGAL DNA; DNA;

ALU SEQUENCE; APC GENE; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; BACTERIOPHAGE LAMBDA; CANCER CELL CULTURE; CHROMOSOME 5Q; CHROMOSOME ABERRATION; CHROMOSOME BREAKAGE; CONTROLLED STUDY; DNA RECOMBINATION; GENE DELETION; GENE INACTIVATION; GENOTYPE; HETEROZYGOSITY LOSS; HOMOZYGOTE; HUMAN; HUMAN CELL; LUNG SMALL CELL CANCER; LYMPHOCYTE; MICROSATELLITE INSTABILITY; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; POLYMORPHIC LOCUS; SEQUENCE ANALYSIS; TUMOR SUPPRESSOR GENE; YEAST ARTIFICIAL CHROMOSOME; CELL CULTURE; CHROMOSOME 5; DNA SEQUENCE; GENETICS; MOLECULAR GENETICS; SMALL CELL CARCINOMA;

BACTERIA (MICROORGANISMS); BACTERIOPHAGE LAMBDA;

CARCINOMA, SMALL CELL; CHROMOSOMES, HUMAN, PAIR 5; DNA; GENE DELETION; HOMOZYGOTE; HUMANS; MOLECULAR SEQUENCE DATA; SEQUENCE ANALYSIS, DNA; TUMOR CELLS, CULTURED;

EID: 0036303364     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100380200048     Document Type: Article

References (27)

1. A general method for isolation of high molecular weight DNA from eukaryotes
2. Polymorphic sites within the MCC and APC loci reveal very frequent loss of heterozygosity in human small cell lung cancer
3. Epigenetic inactivation of a RAS association domain family protein from the lung tumor suppressor locus 3p21.3
4. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
5. A novel somatic point mutation of the RET proto-oncogene in tumor tissues of small cell lung cancer patients
6. Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering
7. Identification and characterization of the familial adenomatous polyposis coli gene
8. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
9. A frequent deletion of chromosome 5q21 in advanced small cell and non-small cell carcinoma of the lung
10. Allelotype and replication error phenotype of small cell lung carcinoma
11. Identification of a novel phospholipase C family gene at chromosome 2q33 that is homozygously deleted in human small cell lung carcinoma
12. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: Identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium
13. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
14. Isolation of DNA sequences amplified at chromosome 19q13.1q13.2 including the AKT2 locus in human pancreatic cancer
15. Detection of aberrations of the p53 alleles and the gene transcript in human tumor cell lines by single-strand conformation polymorphism analysis
16. Suppression of a malignant phenotype in a human prostate cancer cell line by fragments of normal chromosomal region 17q
17. Localization of tumor suppressor activity important in non-small cell lung carcinoma on chromosome 11q
18. Identification of a 428-kb homozygously deleted region disrupting the SEZ6L gene at 22q12.1 in a lung cancer cell line
19. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
20. A deletion polymorphism due to Alu-Alu recombination in intron 2 of the retinoblastoma gene: Association with human gliomas
21. Identification of a candidate tumor suppressor gene, MMACI, at chromosome 10q23.3 that is mutated in multiple advanced cancers
22. An STS-based radiation hybrid map of the human genome
23. Genomic rearrangements of the APC tumor-suppressor gene in familial adenomatous polyposis
24. Identification of a 14-kb deletion involving the promoter region of BRCAI in a breast cancer family
25. Intragenic homozygous deletion of the WT1 gene in Wilms' tumor
26. Evaluation of candidate tumor suppressor genes on chromosome 18 in colorectal cancers
27. Isolation of the human semaphorin III/F gene (SEMA3F) at chromosome 3p21, a region deleted in lung cancer