Accelerated reversal of carbon tetrachloride-induced cirrhosis in rats by the endothelin receptor antagonist TAK-044

Journal of Gastroenterology and Hepatology (Australia)

Volumn 17, Issue 5, 2002, Pages 589-597

  Anselmi, Kristin ^a   Subbotin, Vladimir M ^a,c   Nemoto, Edwin ^b   Gandhi, Chandrashekhar R ^a,b  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c Mirus Bio Corporation   (United States)

Author keywords

Antagonist; Cirrhosis; Endothelin; Fibrosis; Liver; Receptor

Indexed keywords

CARBON TETRACHLORIDE; COLLAGEN TYPE 1; COLLAGENASE; ENDOTHELIN 1; ENDOTHELIN RECEPTOR ANTAGONIST; HYDROXYPROLINE; MESSENGER RNA; TAK 044;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFECT; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; LIVER CIRRHOSIS; LIVER LEVEL; MALE; NONHUMAN; PORTAL HYPERTENSION; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; RECEPTOR DENSITY;

EID: 0036301776     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1746.2002.02705.x     Document Type: Article

References (53)

1. Structural remodeling in hypertensive heart disease and the role of hormones
2. Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension
3. A cytokine reborn? Endothelin-1 in pulmonary inflammation and fibrosis
4. Endothelin antagonists in renal disease
5. Endothelins: Biochemistry and pathophysiologic actions
6. Endothelins. Molecular biology, biochemistry, pharmacology, physiology, and pathophysiology
7. Endothelins: Polyfunctional cytokines
8. Instant cirrhosis. An improved method for producing cirrhosis of the liver in rats by simultaneous administration of carbon tetrachloride and phenobarbitone
9. Adenosine partially prevents cirrhosis induced by carbon tetrachloride in rats
10. Increased hepatic endothelin-1 levels and endothelin receptor density in cirrhotic rats
11. Altered endothelin homeostasis in patients undergoing liver transplantation
12. Endothelin 1 is overexpressed in human cirrhotic liver and exerts effects on activated hepatic stellate cells
13. An endothelin receptor antagonist TAK-044 ameliorates carbon tetrachloride-induced acute liver injury and portal hypertension in rats
14. Endothelin induced contractility of stellate cells from normal and cirrhotic rat liver. Implications for regulation of portal pressure and resistance
15. B
16. Connective tissue and stain
17. Alpha-smooth muscle actin, a differentiation marker of smooth muscle cells, is present in microfilamentous bundles of pericytes
18. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
19. Abrogation of chronic rejection in a murine model of aortic allotrans-plantation by prior induction of donor-specific tolerance
20. A histological semiquantitative scoring system for evaluation of hepatic fibrosis in needle liver biopsy specimens: Comparison with morphometric studies
21. Classification of chronic hepatitis: Diagnosis, grading and staging
22. A detailed analysis of the Knodell score and other histologic parameters as predictors of response to interferon therapy in chronic hepatitis C
23. Histopathological evaluation of liver fibrosis: Quantitative image analysis vs semi-quantitative scores. Comparison with serum markers
24. A simple method to determine nanogram levels of 4-hydroxyproline in biological tissues
25. Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats
26. Endothelin stimulates transforming growth factor-β1 and collagen synthesis in stellate cells from control but not cirrhotic rat liver
27. A rapid sensitive collagenase assay
28. Endotoxin treatment causes an up-regulation of the endothelin system in the liver: Amelioration of increased portal resistance by endothelin receptor antagonism
29. Nitric oxide production in arterial vessels of cirrhotic rats
30. Hemodynamic and hormonal alterations in hepatic cirrhosis
31. B receptor in endothelial cells: Receptor coupling to nitric oxide synthase
32. Endothelin stimulates platelet activating factor synthesis by cultured rat Kupffer cells
33. Endothelin 1 does not play a major role in the homeostasis of arterial pressure in cirrhotic rats with ascites
34. Amelioration of hepatorenal syndrome with selective endothelin-A antagonist
35. Endothelin, a potent peptide agonist in the liver
36. Vesel- and target cell-specific actions of endothelin-1 and endothelin-3 in rat liver
37. Type A, but not type B, endothelin receptor antagonist significantly decrease portal pressure in portal hypertensive rats
38. Endothelin A-receptor blockade worsens endotoxin-induced hepatic microcirculatory changes and necrosis
39. B receptor antagonist, in portal hypertensive rats
40. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors
41. An oral endothelin-A receptor antagonist blocks collagen synthesis and deposition in advanced rat liver fibrosis
42. Chronic blockade of endothelin receptors in cirrhotic rats: Hepatic and hemodynamic effects
43. Tissue inhibitor metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis
44. Stimulation of autocrine platelet-derived growth factor AA-homodimer and transforming growth factor β in vascular smooth muscle cells
45. Endothelin-1 stimulates the biosynthesis of tumor necrosis factor in macrophages: ET receptors, signal transduction and inhibition by dexamethasone
46. Endothelin-induced IL-6 production by rat aortic endothelial cells
47. Tumor necrosis factor alpha (TNFα) and transforming growth factor β1 (TGFβ1) stimulate fibronectin synthesis and the transdifferentiation of fat-storing cells in the rat liver into myofibroblasts
48. Liver fat-storing cells, polypeptide growth factors and the progression of chronic liver inflammation and fibrosis
49. Angiotensin renal fibrosis
50. 1-receptor blockade and angiotensin I-converting enzyme inhibition on survival and cardiac remodeling in chronic heart failure in rats
51. Effect of angiotensin II type 1 receptor blockade on experimental hepatic fibrogenesis
52. Angiotensin-II type 1 receptor interaction is a major regulator for fibrosis development in rats