Endothelin A-receptor blockade worsens endotoxin-induced hepatic microcirculatory changes and necrosis

Gastroenterology

Volumn 115, Issue 2, 1998, Pages 412-420

  Nishida, T ^a   Huang, T P ^a   Seiyama, A ^a   Hamada, E ^a   Kamiike, W ^a   Ueshima, S ^a   Kazuo, H ^a   Matsuda, H ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATE AMINOTRANSFERASE; BILIRUBIN; ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTOXIN; LIPOPOLYSACCHARIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILE FLOW; BILIRUBIN BLOOD LEVEL; ENDOTOXEMIA; ERYTHROCYTE KINETICS; HISTOPATHOLOGY; LIVER BLOOD FLOW; LIVER CIRCULATION; LIVER NECROSIS; LIVER SINUSOID; MALE; NONHUMAN; OXYGEN TRANSPORT; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING;

EID: 0031904173     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0016-5085(98)70208-2     Document Type: Article

References (36)

1. M Pirovino F Meister E Rubli G. Karlaganis Preserved cytosolic and synthetic liver function in jaundice of severe extrahepatic infection Gastroenterology 96 1989 1589 1595
2. R Utili CO Abernathy HJ. Zimmerman Cholestatic effects of Escherichia coli endotoxin on the isolated perfused rat liver Gastroenterology 70 1976 248 253
3. A Billiau F. Vandekerckhove Cytokines and their interactions with other inflammatory mediators in the pathogenesis of sepsis and septic shock Eur J Clin Invest 21 1991 559 573
4. JH Wang HP Redmond RWG Watson D. Bouchier-Hyes Role of lipopolysaccharide and tumor necrosis factor α induction of hepatocyte necrosis Am J Physiol 269 1995 G297 G304
5. I Bohlinger M Leist F Gantner S Angermüller G Tiegs A. Wendel DNA fragmentation in mouse organs during endotoxic shock Am J Pathol 149 1996 1381 1393
6. RS. McCuskey Hepatic microvascular responses to endotox-inemia and sepsis Prog Appl Microcirc 19 1993 76 84
7. M Oshita Y Takei S Kawano H Yoshihara T Hijioka H Fukui M Goto E Masuda Y Nishimura H Fusamoto T. Kamada Roles of endothelin 1 and nitric oxide in the mechanism for vasoconstriction in rat liver J Clin Invest 91 1993 1337 1342
8. A Mallat S. Lotersztajn Multiple hepatic functions of endothelin 1: physiopathological relevance J Hepatol 25 1996 405 413
9. S Moncada RMJ Palmer EA. Higgs Nitric oxide: physiology, pathophysiology, and pharmacology Pharmacol Rev 43 1991 109 142
10. C Housset DC Rockey DM. Bissell Endothelin receptors in rat liver: lipocytes as a contractile target for endothelin 1 Proc Natl Acad Sci USA 90 1993 9266 9270
11. M Bauer JX Zhang I Bauer MG. Clemens Endothelin 1 induced alterations of hepatic microcirculation: sinusoidal and extrasinu-soidal sites of action Am J Physiol 267 1994 G143 G149
12. JX Zhang W Pegoli MG. Clemens Endothelin 1 induces direct constriction of hepatic sinusoids Am J Physiol 266 1994 G624 G632
13. MK Mittal TK Gupta F-Y Lee CC Sieber RJ. Groszmann Nitric oxide modulates hepatic vascular tone in normal rat liver Am J Physiol 267 1994 G416 G422
14. B Battistini P D'Orléans-Juste P. Sirois Biology of disease. Endothelin: circulating plasma levels and presence in other biologic fluids Lab Invest 68 1993 600 628
15. M Goto Y Takei S Kawano K Nagano S Tsuji E Masuda Y Nishimura S Okumura T Kashiwagi H Fusamoto T. Kamada Endothelin 1 is involved in the pathogenesis of ischemia/reperfusion liver injury by hepatic microcirculatory disturbances Hepatology 19 1994 675 681
16. E Kawamura N Yamanaka E Okamoto F Tomoda K. Furukawa Response of plasma and tissue endothelin 1 to liver ischemia and its implication in ischemia-reperfusion injury Hepatology 21 1995 1138 1143
17. A receptor antagonist, BQ-485, and its preventive effect on experimental cerebral vasospasm in dogs Biochem Biophys Res Commun 195 1993 969 975
18. T Nozue A Kobayashi F Uemasu Y Takagi H Endoh A. Sako Plasma endothelin 1 levels of children with cirrhosis J Pediatr Gastroenterol Nutr 21 1995 220 223
19. 15N]nitrate in biological fluids Anal Biochem 126 1982 131 138
20. W Kamiike F Watanabe T Hashimoto K Tagawa Y Ikeda K Nakao Y. Kawashima Changes in cellular levels of ATP and its catabolites in ischemic rat liver J Biochem 91 1982 1349 1356
21. 2 release from single hepatic sinusoids of rats Am J Physiol 267 1994 H944 H951
22. H Kosaka A. Seiyama Elevation of oxygen release by nitroglycerin without increase in blood flow in hepatic microcirculation Nat Med 3 1997 456 459
23. Y Gavrieli Y Sherman SA. Ben-Sasson Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation J Cell Biol 119 1992 493 501
24. G-methyl-L-arginine, an inhibitor of nitric oxide synthesis Biochem Biophys Res Commun 172 1990 1132 1138
25. T Huang T Nishida W Kamiike H Kosaka A Seiyama Y Morimoto S Tanaka S Obunai Y Takei T Shiga H. Matsuda Role of nitric oxide in oxygen transport in rat liver sinusoids during endotoxemia Hepatology 26 1997 336 342
26. J Nishida RS McCusky D McDonnell ES. Fox Protective role of NO in hepatic microcirculatory dysfunction during endotoxemia Am J Physiol 267 1994 G1135 G1141
27. N Kawada T-A Tran-Thi H Klein K. Decker The contraction of hepatic stellate (Ito) cells stimulated with vasoactive substances. Possible involvement of endothelin 1 and nitric oxide in regulation of the sinusoidal tonus Eur J Biochem 213 1993 815 823
28. JX Zhang M Bauer MG. Clemens Vessel- and target cell-specific actions of endothelin 1 and endothelin 3 in rat liver Am J Physiol 269 1995 G269 G277
29. D. Rockey The cellular pathogenesis of portal hypertension: stellate cell contractility, endothelin, and nitric oxide Hepatology 25 1997 2 5
30. S Vemulapalli PJS Chiu M Rivelli CJ Foster EJ. Sybertz Modulation of circulating endothelin levels in hypertension and endotoxemia in rats J Cardiovasc Pharmacol 18 1991 895 903
31. T Ohuchi K Tada K. Akamatsu Endogenous endothelin 1 contributes to liver injury induced by galactosamine and endotoxin in isolated perfused rat liver AmJ Physiol 268 1995 G997 G1003
32. I Kurose S Miura D Fukumura M. Tsuchiya Mechanisms of endothelin-induced macromolecular leakage in microvascular bed of rat mesentery Eur J Pharmacol 250 1993 85 94
33. B receptors on the liver dysfunction and injury caused by endotoxaemia in the rat Br J Pharmacol 119 1996 479 486
34. B receptors J Hepatol 26 1997 1104 1110
35. T Patel GJ. Gores Apoptosis and hepatobiliary disease Hepatology 21 1995 1725 1741
36. M Leist F Gantner I Bohlinger G Tiegs PG Germann A. Wendel Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models Am J Pathol 146 1995 1220 1234