The reverse transcriptase of the R2 non-LTR retrotransposon: Continuous synthesis of cDNA on non-continuous RNA templates

Journal of Molecular Biology

Volumn 316, Issue 3, 2002, Pages 459-473

  Bibiłło, Arkadiusz ^a   Eickbush, Thomas H ^a  

^a UNIVERSITY OF ROCHESTER   (United States)

Author keywords

Priming; Retrotransposons; Retroviruses; Reverse transcriptase; Template switch

Indexed keywords

COMPLEMENTARY DNA; ENDONUCLEASE; OLIGONUCLEOTIDE; PRIMER RNA; PROTEIN; PROTEIN R2; RNA 28S; RNA DIRECTED DNA POLYMERASE; TRANSFER RNA; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; CORRELATION ANALYSIS; DNA CLEAVAGE; DNA SYNTHESIS; ENZYME ACTIVITY; LONG TERMINAL REPEAT; NEUROSPORA CRASSA; PRIORITY JOURNAL; RETROPOSON; RETROVIRUS; REVERSE TRANSCRIPTION; RNA SEQUENCE; RNA STRUCTURE; SPECIES DIFFERENCE;

ARTHROPODA; NEUROSPORA; NEUROSPORA CRASSA;

EID: 0036300893     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.5369     Document Type: Article

References (45)

1. RNA-dependent DNA polymerase in virions of RNA tumor viruses
2. RNA-directed DNA polymerase in virions of Rous sarcoma viruses
3. Reverse transcription
4. Retrons in bacteria
5. Evolutionary analysis of the human genome
6. The impact of L1 retrotransposition on the human genome
7. Reverse transcriptase encoded by a retrotransposon from the trypanosomatid Crithidia fasciculata
8. Reverse transcriptase encoded by a human transposable element
9. Reverse transcription of R2Bm RNA is primed by a nick at the chromosomal target site: A mechanism for non-LTR retrotransposition
10. R2 and related site-specific non-LTR retrotransposons
11. RNA template requirements for target DNA-primed reverse transcription by the R2 retrotransposable element
12. Downstream 28 S gene sequences on the RNA template affect the choice of primer and the accuracy of initiation by the R2 reverse transcriptase
13. Secondary structure model of the RNA recognized by the reverse transcriptase from the R2 retrotransposable element
14. RNA-induced changes in the activity of the endonuclease encoded by the R2 retrotransposable element
15. Identification of the endonuclease domain encoded by R2 and other site-specific, non-long terminal repeat retrotransposable elements
16. High frequency retrotransposition in cultured mammalian cells
17. Transposable elements: How do non-LTR retrotransposons do it?
18. Retrotransposition of the I factor, a non-long terminal repeat retrotransposon of Drosophila, generates tandem repeats at the 3′ end
19. Group II intron mobility occurs by target DNA-primed reverse transcription
20. Retrohoming of a bacterial group II intron: Mobility via complete reverse splicing, independent of homologous DNA recombination
21. A group II intron RNA is a catalytic component of a DNA endonuclease involved in intron mobility
22. Synthesis of small RNAs using T7 RNA polymerase
23. The domain structure and retrotransposition mechanism of R2 elements are conserved throughout arthropods
24. Mechanism of DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase
25. Requirements for strand transfer between internal regions of heteropolymer templates by human immunodeficiency virus reverse transcriptase
26. The age and evolution of non-LTR retrotransposable elements
27. The Mauriceville plasmid of Neurospora crassa: Characterization of a novel reverse transcriptase that begins cDNA synthesis at the 3′ end of template RNA
28. The Mauriceville plasmid of Neurospora supp. uses novel mechanisms for initiating reverse transcription in vitro
29. Origin and evolution of retroelements based on their reverse transcriptase sequences
30. Origin and evolutionary relationships of retroelements
31. Telomerase catalytic subunit homologs from fission yeast and human
32. Reversing time: Origin of telomerase
33. Phylogenetic analysis of ribonuclease H domains suggests a late, chimeric origin of LTR retrotransposable elements and retroviruses
34. Bacterial reverse transcriptase
35. The Mauriceville plasmid reverse transcriptase can initiate cDNA synthesis de novo and may be related to reverse transcriptase and DNA polymerase progenitor
36. It's prime time for reverse transcriptase
37. Crystal structure at 3.5 angstrom resolution of HIV-1 reverse transcriptase complexed with an inhibitor
38. Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA
39. De novo and DNA primer-mediated initiation of cDNA synthesis by the Mauriceville retroplasmid reverse transcriptase involve recognition of a 3′ CCA sequence
40. Analysis of the 5′ junctions of R2 insertions with the 28 S gene: Implications for non-LTR retrotransposition
41. Integration of Bombyx mori R2 sequences into the 28 S ribosomal DNA loci of D. melanogaster
42. Nucleic acid chaperone activity of the ORF1 protein from the mouse LINE-1 retrotransposon
43. Functional expression of a sequence-specific endonuclease encoded by the retrotransposon R2Bm
44. R4, a non-LTR retrotransposon specific to the large subunit rRNA gene of nematodes