Carbogen breathing after irradiation enhances the effectiveness of tirapazamine in SiHa tumors but not SCCVII tumors in mice

Radiation Research

Volumn 158, Issue 1, 2002, Pages 94-100

  Minchinton, Andrew I ^a   Tonn, Danika A ^a   Sutherland, Darren P ^a   Kyle, Alastair H ^a  

^a BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOGEN; TIRAPAZAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD VESSEL; BREATHING; CANCER RADIOTHERAPY; CELL KILLING; CELL SURVIVAL; CONTROLLED STUDY; DRUG DIFFUSION; DRUG PENETRATION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOXIC CELL; MOUSE; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL;

EID: 0036299864     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/0033-7587(2002)158[0094:CBAIET]2.0.CO;2     Document Type: Article

References (33)

1. SR 4233 (Tirapazamine): A new anticancer drug exploiting hypoxia in solid tumours
2. Molecular mechanisms for the hypoxia dependent activation of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233)
3. Unusual oxygen concentration dependence of toxicity of SR-4233, a hypoxic cell toxin
4. Definitive evidence for hypoxic cells influencing cure in cancer therapy
5. Radiotherapy and hyperbaric oxygen in head and neck cancer
6. 2 predicts the survival in advanced cancer of the uterine cervix: Updated analysis of an open prospective clinical study
7. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
8. Importance of tumour hypoxia in radiotherapy. A meta-analysis of controlled clinical trials
9. The histological structure of some human lung cancers and the possible implications for radiotherapy
10. Evidence for acutely hypoxic cells in mouse tumours and a possible mechanism of reoxygenation
11. Acute hypoxia in tumour: Implications for modifiers of radiation effects
12. Hypoxic cells as specific drug targets for chemotherapy
13. Response of Chinese hamster ovary cells to anti-cancer drugs under aerobic and hypoxic conditions
14. Measurement of delivery and metabolism of tirapazamine through tumour tissue using the multilayered cell culture model
15. Extravascular diffusion of tirapazamine: Effect of metabolic consumption assessed using the multicellular layer model
16. The effect of carbogen on the response of spontaneous tumors in mice to radiotherapy
17. Carbogen breathing during radiation therapy - The Radiation Therapy Oncology Group Study
18. Hypoxic cervical cancers with low apoptotic index are highly aggressive
19. Tumor oxygenation: A new predictive parameter in locally advanced cancer of the uterine cervix
20. 2 tension measurements
21. Normobaric oxygen treatment during radiotherapy for carcinoma of the uterine cervix. Results from a prospective controlled randomized trial
22. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma
23. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
24. Radiosensitization with normobaric oxygen and carbogen
25. Radiosensitisation in normal tissues with oxygen, carbogen or nicotinamide: Therapeutic gain comparisons for fractionated x-ray schedules
26. 2 histograph
27. Carbogen inhalation in cervical cancer: Assessment of oxygenation change
28. Oxygen tension in primary gynaecological tumours: The influence of carbon dioxide concentration
29. Improvement in human tumour oxygenation with carbogen of varying carbon dioxide concentrations
30. Pharmacokinetics and bioreductive metabolism of the novel benzotriazine di-N-oxide hypoxic cell cytotoxin tirapazamine (WIN 59075; SR 4233; NSC 130181) in mice
31. Contribution of transient blood flow to tumour hypoxia in mice
32. Intermittent blood flow in a murine tumour: Radiobiological effects