Cyclosporin A-induced autoimmunity in the rat: Central versus peripheral tolerance

International Journal of Immunopathology and Pharmacology

Volumn 15, Issue 2, 2002, Pages 81-87

  Damoiseaux, Jan G M C ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Autoimmunity; Cyclosporin A; Rat; Regulatory T cells; Thymus

Indexed keywords

CYCLOSPORIN A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; AUTOREGULATION; BONE MARROW TRANSPLANTATION; BREAST METASTASIS; CELL MATURATION; CLONAL ANERGY; CONTROLLED STUDY; GRAFT VERSUS HOST REACTION; IMMUNOLOGICAL TOLERANCE; NONHUMAN; PRIORITY JOURNAL; RAT; REVIEW; SCLERODERMA; T LYMPHOCYTE; THYMUS; WHOLE BODY RADIATION; X IRRADIATION;

EID: 0036295953     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: 10.1177/039463200201500202     Document Type: Review

References (52)

1. Graft-versus-host disease in cyclosporin A-treated rats after syngeneic and autologous bone marrow reconstitution
2. Capacity of cyclosporine to induce auto-graft-versus-host disease and impair intrathymic T cell differentiation
3. Induction of graft-versus-host disease after autologous bone marrow transplantation
4. Requirements for the induction and adoptive transfer of cyclosporine-induced syngeneic graft-verus-host-disease
5. Graft-versus-host disease: The need for a new terminology
6. Chronic cyclosporine-induced autoimmune disease in the rat: A new experimental model for scleroderma
7. Cutaneous immunopathology of Cyclosporin-A induced autoimmunity in the rat
8. Autologous graft-versus-host disease: A novel approach for antitumor immunotherapy
9. Multiple effects of Cyclosporin-A on the thymus in relation to T-cell development and autoimmunity
10. Host resistance to cyclosporine induced syngeneic graft-versus-host disease: Requirements for two distinct lymphocyte subsets
11. Specificity of effector T lymphocytes in autologous graft-versus-host disease: Role of the major histocompatibility complex class II invariant chain peptide
12. Promiscuous recognition of major histocompatibility complex class II determinants in cyclosporine-induced syngeneic graft-versus-host disease
13. Characterization of the pathogenic autoreactive T cells in cyclosporine-induced syngeneic graft-versus-host disease
14. Cyclosporin-induced autoimmunity: Conditions for expressing disease, requirement for intact thymus, and potency estimates of autoimmune lymphocytes in drug-treated rats
15. X-irradiation of the thymus is not required for the induction of Cyclosporin-A induced autoimmunity
16. The differential effects of X-irradiation and Cyclosporin-A administration on the thymus with respect to the generation of Cyclosporin-A induced Autoimmunity
17. The lesions of cyclosporine-induced autoimmune disease can be equally well elicited by CD4 or CD8 effector T cells
18. Susceptibility to clinically manifest cyclosporine A (CsA)-induced autoimmune disease is associated with Interferon-gamma (IFN-γ) producing CD45RC+RT6- Thelper cells
19. Abnormal differentiation of thymocytes in mice treated with Cyclosporin A
20. Effects of Cyclosporin A on T cell development and clonal deletion
21. The effects of in vivo cyclosporin A administration on rat thymic dendritic cells
22. Defective de novo thymocyte maturation in cyclosporin A-induced autoimmunity: Expression of costimulatory and activation molecules
23. The mechanism of action of cyclosporin A and FK506
24. Inhibition of T-cell signaling pathways by immunophilin drug complexes: Are side effects inherent to immunosuppressive properties?
25. Molecular cloning of rat interleukin 4 cDNA and analysis of the cytokine repertoire of subsets of CD4+ T cells
26. The balance between CD45RChigh and CD45RClow CD4 T cells in rats is intrinsic to bone marrow-derived cells and is genetically controlled
27. OX-22 high CD4+ T Cells induce wasting disease with multiple organ pathology: Prevention by the OX-22 low subset
28. Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential
29. Regulatory T cells in the control of autoimmunity: The essential role of transforming growth factor β and interleukin 4 in the prevention of autoimmune thyroiditis in rats by peripheral CD4+CD45RC- cells and CD4+CD8- thymocytes
30. The third function of the thymus
31. Age-related factors in cyclosporine-induced syngeneic graft-versus-host disease: Regulatory role of marrow-derived T lymphocytes
32. Cyclosporin A-induced autologous graft-versus-host disease: A prototypical model of autoimmunity and active (dominant) tolerance coordinately induced by recent thymus emigrants
33. Tolerance to cyclosporin a-induced autologous graft-versus-host disease is mediated by a cd4(+)cd25(+) subset of recent thymic emigrants
34. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation
35. CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25- subpopulations
36. Characterization of peripheral autoregulatory mechanisms that prevent development of Cyclosporin-induced syngeneic graft-versus-host disease
37. Successful in vitro graft-versus-tumor effect against an Ia-bearing tumor using cyclosporine-induced syngeneic graft-versus-host disease in the rat
38. Susceptibility and resistance to Cyclosporin A-induced autoimmunity in rats
39. Induction of a syngeneic graft-versus-host disease-like syndrome in DBA/2 mice
40. Strain specificity in the induction of syngeneic graft-versus-host disease in mice
41. Relationship of cyclosporin A-mediated inhibition of clonal deletion and development of syngeneic graft-versus-host disease
42. Cyclosporin A-induced autoimmune disease in mice
43. Natural killer 1.1(+) T cells and "natural suppressor" T cells in the bone marrow
44. A dominant role for non-MHC gene effects in susceptibility to cyclosporin A (CsA)-induced autoimmunity
45. Graft-versus-leukemia in the rat-the antileukemic efficacy of syngeneic and allogeneic graft-versus-host disease
46. Cyclosporine-induced syngeneic graft-vs-host disease: Prevention of autoaggression by treatment with monoclonal antibodies to T lymphocyte cell surface determinants and to MHC class II antigens
47. T cell development and susceptibility to cyclosporin A-induced autoimmunity in MHC-matched bone marrow/thymus chimaera's
48. Genome-wide linkage analysis of chronic relapsing experimental autoimmune encephalomyelitis in the rat identifies a major susceptibility locus on chromosome 9
49. A genome-wide search identifies two susceptibility loci for experimental autoimmune encephalomyelitis on rat chromosomes 4 and 10
50. Rat chromosome 9 bears a major susceptibility locus for IgE response
51. In vivo models of dominant T-cell tolerance: Where do we stand today?
52. Susceptibility to cyclosporin A-induced autoimmunity: Strain differences in relation to autoregulatory T cells