Multiple effects of cyclosporin A on the thymus in relation to T-cell development and autoimmunity

Clinical Immunology and Immunopathology

Volumn 82, Issue 3, 1997, Pages 197-202

  Damoiseaux, Jan G M C ^a   Beijleveld, Leo J J ^a   Van Breda Vriesman, Peter J C ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; MAJOR HISTOCOMPATIBILITY ANTIGEN;

ANIMAL CELL; AUTOIMMUNITY; HUMAN; HUMAN CELL; IMMUNE SYSTEM; IMMUNOSUPPRESSIVE TREATMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; REVIEW; T LYMPHOCYTE; THYMOCYTE;

EID: 0031104687     PISSN: 00901229     EISSN: None     Source Type: Journal    
DOI: 10.1006/clin.1996.4254     Document Type: Review

References (41)

1. 1. Glazier, A., Tutschka, P. J., Farmer, E. R., and Santos, G. W., Graft-versus-host disease in cyclosporin A-treated rats after syngeneic and autologous bone marrow reconstitution. J. Exp. Med. 158, 1-8, 1983.
2. 2. Cheney, R. T., and Sprent, J., Capacity of cyclosporine to induce autograft-versus-host disease and impair intrathymic T cell differentiation. Transpl. Proc. 17, 528-530, 1985.
3. 3. Jones, R. S., Hess, A. D., Mann, R. B., Piantadosi, S., Vogelsang, G. B., Farmer, E. R., Geller, R. B., and Santos, G. W., Induction of graft-versus-host disease after autologous bone marrow transplantation. Lancet 1, 754-747, 1989.
4. 4. Bryson, J. S., Jennings, C. D., Caywood, B. E., and Kaplan, A. M., Induction of a syngeneic graft-versus-host disease-like syndrome in DBA/2 mice. Transplantation 48, 1042-1047, 1989.
5. 5. Bos, G. M. J., Majoor, G. D., van Breda Vriesman, P. J. C., Graft-versus-host disease: The need for a new terminology. Immunol. Today 11, 433-436, 1990.
6. 6. Sorokin, R., Kimura, H., Schroder, K., Wilson, D. H., and Wilson, D. B., Cyclosporin-induced autoimmunity: Conditions for expressing disease, requirement for intact thymus, and potency estimates of autoimmune lymphocytes in drug-treated rats. J. Exp. Med. 164, 1615-1625, 1986.
7. 7. Beijleveld, L. J. J., Damoiseaux, J. G. M. C., Wodzig, K. W. H., and van Breda Vriesman, P. J. C., X-irradiation of the thymus is not required for the induction of cyclosporin-A induced autoimmunity. Transplantation 59, 1601-1605, 1995.
8. 8. Glazier, A., Tutschka, P. J., and Farmer, E. R., Studies on the immunobiology of syngeneic and autologous graft-versus-host disease in cyclosporine-treated rats. Transpl. Proc. 15, 3035-3041, 1983.
9. 9. Beschorner, W. E., Di Gennaro, K. A., Hess, A. D., and Santos, G. W., Cyclosporine and the thymus: Influence of irradiation and age on thymic immunopathology and recovery. Cell. Immunol. 110, 350-364, 1987.
10. 10. Kosugi, A., Sharrow, S. O., and Shearer, G. M., Effect of cyclosporin A on lymphopoiesis. I. Absence of mature T cells in thymus and periphery of bone marrow transplanted mice treated with cyclosporin A. J. Immunol. 142, 3026-3032, 1989.
11. 11. Jenkins, M. K., Schwartz, R. H., and Pardoll, D. M., Effects of Cyclosporin A on T cell development and clonal deletion. Science 241, 1655-1658, 1988.
12. 12. Beijleveld, L. J. J., Groen, H., Broeren, C. P. M., Klatter, F. A., Kampinga, J., Damoiseaux, J. G. M. C., and van Breda Vriesman, P. J. C., Susceptibility for clinically manifest cyclosporine A induced autoimmune disease is associated with Interferon-γ producing CD45RC + RT6-T helper cells. Clin. Exp. Immunol. 105, 486-496, 1996.
13. 13. Fischer, A. C., Beschorner, W. E., and Hess, A. D., Requirements for the induction and adoptive transfer of cyclosporine-induced syngeneic graft-verus-host-disease. J. Exp. Med. 169, 1031-1041, 1989.
14. 14. Schreiber, S. L., and Crabtree, G. R., The mechanism of action of cyclosporin A and FK506. Immunol. Today 13, 136-141, 1992.
15. 15. Schreier, M. H., Baumann, G., and Zenke, G., Inhibition of T-cell signaling pathways by immunophilin drug complexes: Are side effects inherent to immunosuppressive properties? Transplant. Proc. 25, 502-507, 1993.
16. 16. Gao, E. K., Lo, D., Cheney, R., Kanagawa, O., and Sprent, J., Abnormal differentiation of thymocytes in mice treated with Cyclosporin A. Nature 336, 176-179, 1988.
17. 17. Beijleveld, L. J. J., Damoiseaux, J. G. M. C., and van Breda Vriesman, P. J. C., The differential effects of X-irradiation and Cyclosporin-A administration on the thymus with respect to the generation of Cyclosporin-A induced Autoimmunity. Dev. Immunol. 4, 127-138, 1995.
18. 18. Kosugi, A., Zuniga-Pflucker, J. C., Sharrow, S. O., Kruisbeek, A. M., and Shearer, G. M., Effect of cyclosporin A on lymphopoiesis. II. Developmental defects of immature and mature thymocytes in fetal thymus organ cultures treated with cyclosporin A. J. Immunol. 143, 3134-3140, 1989.
19. 19. Matsuhashi, N., Kawase, Y., and Suzuki, G., Effects of cyclosporine A on thymocyte differentiation in fetal thymus organ culture. Cell. Immunol. 123, 307-315, 1989.
20. 20. Beschorner, W. E., Namnoum, J. D., Hess, A. D., Shinn, C. A., and Santos, G. W., Cyclosporin A and the thymus. Am. J. Pathol. 126, 487-496, 1987.
21. 21. Schuurman, H.-J., van Loveren, H., Rozing, J., van Dijk, A., Loeber, J. G., and Vos, J. G., Cyclosporin and the rat thymus. An immunohistochemical study. Thymus 16, 235-254, 1990.
22. 22. Damoiseaux, J. G. M. C., Beijleveld, L. J. J., and van Breda Vriesman, P. J. C., The effects of in vivo cyclosporin A administration on rat thymic dendritic cells. Clin. Exp. Immunol. 96, 513-520, 1994.
23. 23. Surh, C. D., Ernst, B., and Sprent, J., Growth of epithelial cells in the thymic medulla is under the control of mature T cells. J. Exp. Med. 176, 611-616, 1992.
24. 24. Ritter, M. A., and Boyd, R. L., Development in the thymus: It takes two to tango. Immunol. Today 14, 462-469, 1993.
25. 25. Burkly, L., Hession, C., Ogata, L., Reilly, C., Marconi, L. A., Olson, D., Tizard, R., Cate, R., and Lo, D., Expression of relB is required for the development of thymic medulla and dendritic cells. Nature 373, 531-536, 1995.
26. 26. Van Ewijk, W., and Shores, E. W., Singer, A. Crosstalk in the mouse thymus. Immunol. Today 15, 214-217, 1994.
27. 27. Schönrich, G., Momburg, F., Hämmerling, G. J., and Arnold, B., Anergy induced by thymic medullary epithelium. Eur. J. Immunol. 22, 1687-1691, 1992.
28. 28. Surh, C. D., and Sprent, J., T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 372, 100-103, 1994.
29. 29. Lee, N. A., Loh, D. Y., and Lacy, E., CD8 surface levels alter the fate of alpha/beta T cell receptor-expressing thymocytes in transgenic mice. J. Exp. Med. 175, 1013-1025, 1992.
30. 30. Sebzda, E., Wallace, V. A., Mayer, J., Yeung, R. S., Mak, T. W., and Ohashi, P. S., Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science 263, 1615-1618, 1994.
31. 31. Urdahl, K. B., Pardoll, D. M., and Jenkins, M. K., Cyclosporin A inhibits positive selection and delays negative selection in ab TCR transgenic mice. J. Immunol. 152, 2853-2859, 1994.
32. 32. Milicevic, N. M., Milicevic, Z., and Colic, M., Macrophages of the rat thymus after cyclosporin treatment: histochemical, enzymehistochemical and immunohistochemical study. Virchows Arch. B Cell Pathol. 57, 237-244, 1989.
33. 33. McCarthy, S. A., Cacchione, R. N., Mainwaring, M. S., and Cairns, J. S., The effects of immunosuppressive drugs on the regulation of activation-induced apoptotic cell death in thymocytes. Transplantation 54, 543-547, 1992.
34. + thymocytes undergoing thymic selection: Requirement of calcineurin activation for thymic positive selection but not negative selection. J. Exp. Med. 181, 927-941, 1995.
35. 35. Groux, H., Monte, D., Plouvier, B., Capron, A., and Ameisen, J.-C., CD3-mediated apoptosis of human medullary thymocytes and activated peripheral T cells: Respective roles of interleukin-1, interleukin-2, interferon-g and accessory cells. Eur. J. Immunol. 23, 1623-1629, 1993.
36. 36. Bryson, J. S., Caywood, B. E., and Kaplan, A. M., Relationship of cyclosporin A-mediated inhibition of clonal deletion and development of syngeneic graft-versus-host disease. J. Immunol. 147, 391-397, 1991.
37. 37. Wodzig, K. W. H., Majoor, G. D., and van Breda Vriesman, P. J. C., Susceptibility and resistance to Cyclosporin A-induced autoimmunity in rats. Autoimmunity 16, 29-37, 1993.
38. 38. Fischer, A. C., and Hess, A. D., Age-related factors in cyclosporine-induced syngeneic graft-versus-host disease: Regulatory role of marrow-derived T lymphocytes. J. Exp. Med. 172, 85-94, 1990.
39. 39. Chow, L. H., Mosbach-Ozmen, L., Ryffel, B., and Borel, J. F., Syngeneic Graft-versus-host disease induced by cyclosporine -A reappraisal. Transplantation 46, 107S-112S, 1988.
40. 40. Bucy, R. P., Xu, X. Y., Li, J., and Huang, G. Q., Cyclosporin A-induced autoimmune disease in mice. J. Immunol. 151, 1039-1050, 1993.
41. 41. Hess, A. D., Fischer, A. C., Horwitz, L., Bright, E. C., Laulis, M. K., Characterization of peripheral autoregulatory mechanisms that prevent development of Cyclosporin-induced syngeneic graft-versus-host disease. J. Immunol. 153, 400-411, 1994.