Relationship between the self-splicing activity and the solidity of the master domain of the Tetrahymena group I ribozyme

Biochemical and Biophysical Research Communications

Volumn 291, Issue 5, 2002, Pages 1225-1231

  Oe, Yoshihiko ^a   Ikawa, Yoshiya ^a   Shiraishi, Hideaki ^a   Inoue, Tan ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Group I intron; P3 P7 domain; Ribozyme; Self splicing; Tetrahymena

Indexed keywords

GUANOSINE; RIBOZYME;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME STABILITY; ENZYME STRUCTURE; INTRON; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; TETRAHYMENA; WILD TYPE;

TETRAHYMENA;

EID: 0036293714     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2002.6609     Document Type: Article

References (37)

1. Modelling of the three-dimensional architecture of group I catalytic introns based on comparative sequence analysis
2. The structure of group I ribozymes
3. New loop-loop tertiary interactions in self-splicing introns of subgroup IC and ID: A complete 3D model of the Tetrahymena thermophila ribozyme
4. A preorganized active site in the crystal structure of the Tetrahymena ribozyme
5. Minimum secondary structure requirements for catalytic activity of a self-splicing group I intron
6. A region of group I introns that contains universally conserved residues but is not essential for self-splicing
7. Minimal catalytic domain of a group I self-splicing intron RNA
8. Self-splicing of the Tetrahymena group I ribozyme without conserved base-triples
9. Identification of phosphate groups important to self-splicing of the Tetrahymena rRNA intron as determined by phosphorothioate substitution
10. Analysis of the role of phosphate oxygens in the group I intron from Tetrahymena
11. Metal coordination sites that contribute to structure and catalysis in the group I intron from Tetrahymena
12. The environment of two metal ions surrounding the splice site of a group I intron
13. Visualizing metal-ion-binding sites in group I introns by iron(II)-mediated Fenton reactions
14. Localization of metal ion binding sites in Group I intron RNA
15. The guanosine binding site of the Tetrahymena ribozyme
16. Group I intron self-splicing with adenosine: Evidence for a single nucleoside-binding site
17. An axial binding site in the Tetrahymena precursor RNA
18. The chemical basis of adenosine conservation throughout the Tetrahymena ribozyme
19. Concerted kinetic folding of a multidomain ribozyme with a disrupted loop-receptor interaction
20. Beyond kinetic traps in RNA folding
21. Probing the folding landscape of the Tetrahymena ribozyme: Commitment to form the native conformation is late in the folding pathway
22. The kinetic folding pathway of the Tetrahymena ribozyme reveals possible similarities between RNA and protein folding
23. Folding intermediates of a self-splicing RNA: Mispairing of the catalytic core
24. Fast folding of a ribozyme by stabilizing core interactions: Evidence for multiple folding pathways in RNA
25. Kinetic intermediates trapped by native interactions in RNA folding
26. 2+ concentration for kinetic folding of the Tetrahymena ribozyme
27. A single-molecule study of RNA catalysis and folding
28. Small angle X-ray scattering reveals a compact intermediate in RNA folding
29. Magnesium-dependent folding of self-splicing RNA: Exploring the link between cooperativity, thermodynamics, and kinetics
30. The effect of long-range loop-loop interactions on folding of the Tetrahymena self-splicing RNA
31. A deteriorated triple-helical scaffold accelerates formation of the Tetrahymena ribozyme active structure
32. Role of conserved sequence elements 9L and 2 in self-splicing of the Tetrahymena ribosomal RNA precursor
33. Site-directed mutagenesis of core sequence elements 9R3, 9L, 9R, and 2 in self-splicing Tetrahymena pre-rRNA
34. Compensatory mutations demonstrate that P8 and P6 are RNA secondary structure elements important for processing of a group I intron
35. Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates
36. Kinetic oligonucleotide hybridization for monitoring kinetic folding of large RNAs