Endogenous anti-inflammatory mediators from arachidonate in human neutrophils

Biochemical and Biophysical Research Communications

Volumn 290, Issue 1, 2002, Pages 219-224

  Vachier, I ^a   Chanez, P ^a   Bonnans, C ^a   Godard, P ^a   Bousquet, J ^a   Chavis, C ^a  

^a HÔPITAL ARNAUD DE VILLENEUVE   (France)

Author keywords

Anti inflammatory mediators; Hydroxyeicosatetraenoic acid; Inflammation; Leukotriene B4; Lipoxin; Neutrophils

Indexed keywords

14 EPILIPOXIN B 4; 15 EPILIPOXIN B 4; ARACHIDONIC ACID; AUTACOID; CALCIMYCIN; CALCIUM IONOPHORE; HYDROXYICOSATETRAENOIC ACID; LEUKOTRIENE B4; LIPOXIN; LIPOXIN A 4; PROTEIN PRECURSOR; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL METABOLISM; CHIRALITY; CONTROLLED STUDY; DIASTEREOISOMER; DRUG SYNTHESIS; ENANTIOMER; HUMAN; HUMAN CELL; INCUBATION TIME; INFLAMMATION; NEUTROPHIL; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN TRANSPORT;

EID: 0036291567     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.6155     Document Type: Article

References (54)

1. Lipoxins: Novel series of biologically active compounds formed from arachidonic acid in human leukocytes
2. Lipoxin A: Stereochemistry and biosynthesis
3. Identification of lipoxin A4 and its relationship to the sulfidopeptide leukotrienes C4, D4, and E4 in the bronchoalveolar lavage fluids obtained from patients with selected pulmonary diseases
4. Lipoxins: Biosynthesis and evidence for their involvement in respiratory disease
5. Lipoxin biosynthesis and its impact in inflammatory and vascular events
6. Update on arachidonic acid cascade - Leukotrienes and lipoxins in disease models
7. Lipoxin A(4) stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A(4) receptor
8. Lipoxins A4 and B4 inhibit leukotriene B4 generation from human neutrophil leukocyte suspensions
9. Inhibition of leukotriene B4 in neutrophils by lipoxins A4 and B4
10. Lipoxin A4: A novel anti-inflammatory molecule?
11. Lipoxins and novel aspirin-triggered 15-epi-lipoxins (ATL): A jungle of cell-cell interactions or a therapeutic opportunity?
12. Lipoxin and aspirin-triggered 15-epi-lipoxin cellular interactions anti-inflammatory lipid mediators
13. Mechanisms in anti-inflammation and resolution: The role of lipoxins and aspirin-triggered lipoxins
14. Conversion of endogenous arachidonic acid to 5,15-diHETE and lipoxins by polymorphonuclear cells from patients with rheumatoid arthritis
15. Spatial requirements for 15-(R)-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid synthesis within the cyclooxygenase active site of murine COX-2 - Why acetylated COX-1 does not synthesize 15-(R)-HETE
16. Arachidonic acid oxygenation by COX-1 and COX-2 - Mechanisms of catalysis and inhibition
17. Stereospecificity of hydrogen abstraction in the conversion of arachidonic acid to 15R-HETE by aspirin-treated cyclooxygenase-2 - Implications for the alignment of substrate in the active site
18. Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions
19. Aspirin-triggered lipoxins (15-epi-LX) are generated by the human lung adenocarcinoma cell line (A549)-neutrophil interactions and are potent inhibitors of cell proliferation
20. Lipoxins, leukocyte recruitment and the resolution phase of acute glomerulonephritis
21. Aspirin-triggered 15-epi-lipoxin A(4) (LXA(4)) and LXA(4) stable analogues are potent inhibitors of acute inflammation: Evidence for anti-inflammatory receptors
22. Neutrophil-mediated changes in vascular permeability are inhibited by topical application of aspirin-triggered 15-epi-lipoxin A(4) and novel lipoxin B-4 stable analogues
23. Regulation of T-lymphocyte mitogenesis by the leukocyte product 15-hydroxy-eicosatetraenoic acid (15-HETE)
24. Inhibition of human leukocyte 5-lipoxygenase by 15-HPETE and related eicosanoids
25. The suppression of 5-lipoxygenation of arachidonic acid in human polymorphonuclear leucocytes by the 15-lipoxygenase product (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid: Structure-activity relationship and mechanism of action
26. 15-Hydroxy-eicosatetraenoic acid has minor anti-inflammatory properties in colitis
27. Arachidonic acid lipoxygenases as essential regulators of cell survival and apoptosis
28. Mono(S) hydroxy fatty acids: Novel ligands for cytosolic actin
29. Novel membrane target proteins for lipoxygenase-derived mono(S)hydroxy fatty acids
30. 14,15-Dihydroxy-5,8,10,12-eicosatetraenoic acid. Enzymatic formation from 14,15-leukotriene A4
31. Predominant generation of 15-lipoxygenase metabolites of arachidonic acid by epithelial cells from human trachea
32. Mechanisms of leukotriene formation: Hemoglobin-catalyzed transformation of 15-HPETE into 8,15-DiHETE and 14,15-DiHETE isomers
33. Stereochemistry, total synthesis, and biological activity of 14,15-dihydroxy-5,8,10,12-eicosatetraenoic acid
34. Inhibition of human natural killer cell activity by (14R, 15S)-14,15-dihydroxy-5Z,8Z,10E,12E-icosatetraenoic acid
35. Pathogenetic role of phagocytic abnormalities in human virus immunodeficiency infection: Possible therapeutical approaches. A review
36. Neutrophil priming: Pathophysiological consequences and underlying mechanisms
37. The neutrophil: One of the cellular targets of interleukin-10
38. Role of leukotrienes in antimicrobial defense of the lung
39. Mechanisms of leukocyte-mediated tissue injury induced by interleukin-2
40. Neutrophils as a source of cytokines in inflammation
41. The role of neutrophils in myocardial ischemia-reperfusion injury
42. 5(S),15(S)-Dihydroxyeicosatetraenoic acid and lipoxin generation in human polymorphonuclear cells: Dual specificity of 5-lipoxygenase toward endogenous and exogenous precursors
43. Selective incorporation of (15S)-hydroxyeicosatetraenoic acid in phosphatidylinositol of human neutrophils: Agonist-induced deacylation and transformation of stored hydroxyeicosanoids
44. Interleukin-4 enhances 15-lipoxygenase activity and incorporation of 15(S)-HETE into cellular phospholipids in cultured pulmonary epithelial cells
45. Substitution of 15-hydroxyeicosatetraenoic acid in the phosphoinositide signaling pathway
46. Functional characteristics of bronchial epithelium obtained by brushing from asthmatic and normal subjects
47. Expression of the high-affinity receptor for IgE on bronchial epithelial cells of asthmatics
48. Lipoxin formation in human nasal polyps and bronchial tissue
49. Dipalmitoylphosphatidylcholine modulates inflammatory functions of monocytic cells independently of mitogen activated protein kinases
50. Lipoxin A-4 and B-4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells
51. Polyisoprenyl phosphate (PIPP) signaling regulates phospholipase D activity: A ’stop’ signaling switch for aspirin-triggered lipoxin A(4)
52. Cutting edge: Lipoxins rapidly stimulate nonphylogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages
53. Lung cancer cell lines inhibit leukotriene B-4 production by human polymorphonuclear leukocytes at the level of phospholipase A(2)
54. A severely affected infant with absence of cysteinyl leukotrienes in cerebrospinal fluid: Further evidence that leukotriene C-4-synthesis deficiency is a new neurometabolic disorder