Abnormal protein tyrosine kinases associated with human haematological malignancies

Chinese Journal of Cancer Research

Volumn 14, Issue 2, 2002, Pages 79-83

  Sun, Xue Mei ^a   Lieschke, Graham J ^b  

^a NANJING UNIVERSITY   (China)

^b ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Anaplastic large cell lymphoma (ALCL); BCR ABL; Chronic myelogenous leukemia (CML); Hematopoietic malignancy; Protein tyrosine kinase (PTK); Protein tyrosine kinase inhibitor; STI 571

Indexed keywords

ANAPLASTIC LYMPHOMA KINASE; BCR ABL PROTEIN; GENE PRODUCT; HYBRID PROTEIN; NPM ALK PROTEIN; PROTEIN TYROSINE KINASE; TEL ABL PROTEIN; TEL JAK2 PROTEIN; TEL PDGFRBETA PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BLOOD DISEASE; CELL GROWTH; CHROMOSOME 2P; CHROMOSOME TRANSLOCATION; CHRONIC MYELOID LEUKEMIA; CORRELATION ANALYSIS; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE MUTATION; HUMAN; HYBRID GENE; LARGE CELL LYMPHOMA; MOLECULAR CLONING; NONHUMAN; PATHOGENESIS; SIGNAL TRANSDUCTION; TUMOR DIFFERENTIATION;

EID: 0036287933     PISSN: 10009604     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11670-002-0018-3     Document Type: Article

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5. BCR-ABL activates pathways mediating cytokine independence and protection against apoptosis in murine hematopoietic cells in a dose dependent manner
6. Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr-abl transduced bone marrow
7. p190 fusion gene made by homologous recombination causes B-cell acute lymphoblastic leukemias in chimeric mice with independence of the endogenous bcr product
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14. Cytokine receptor signaling
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18. The TEL platelet derived growth factor receptor (PDGFRβ) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGFRβ kinase-dependent signaling pathways
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