Accurate translocation of mRNA by the ribosome requires a peptidyl group or its analog on the tRNA moving into the 30S P site

Molecular Cell

Volumn 9, Issue 5, 2002, Pages 1125-1131

  Fredrick, Kurt ^a   Noller, Harry F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PEPTIDE; TRANSFER RNA;

ACYLATION; ARTICLE; CODON; GENE TRANSLOCATION; OPEN READING FRAME; RIBOSOME;

EID: 0036282055     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(02)00523-3     Document Type: Article

References (32)

1. The complete atomic structure of the large ribosomal subunit at 2.4 Å resolution
2. Selection of the mRNA translation initiation region by Escherichia coli ribosomes
3. Recognition of Escherichia coli valine transfer RNA by its cognate synthetase: A fluorine-19 NMR study
4. Efficient reconstitution of functional Escherichia coli 30S ribosomal subunits from a complete set of recombinant small subunit ribosomal proteins
5. Identification of molecular interactions between P site tRNA and the ribosome essential for translocation
6. Tagging ribosomal protein S7 allows rapid identification of mutants defective in assembly and function of 30 S subunits
7. Factor-free ("non-enzymic") and factor-dependent systems of translation of polyuridylic acid by Escherichia coli ribosomes
8. Selection of the initiator tRNA by Escherichia coli initiation factors
9. Domains of initiator tRNA and initiation codon crucial for initiator tRNA selection by Escherichia coli IF3
10. Conformational changes in the ribosome induced by translational miscoding agents
11. EF-G-catalyzed translocation of anticodon stem-loop analogs of transfer RNA in the ribosome
12. Mapping the inside of the ribosome with an RNA helical ruler
13. Nucleotide sequences involved in bacteriophage T4 gene 32 translational self-regulation
14. Constraints on the accuracy of messenger RNA movement
15. Phe in the exit site of Escherichia coli ribosomes
16. Binding of the 3′ terminus of tRNA to 23S rRNA in the ribosomal exit site actively promotes translocation
17. Interaction of tRNA with 23S rRNA in the ribosomal A, P, and E sites
18. Intermediate states in the movement of transfer RNA in the ribosome
19. The structural basis of ribosome activity in peptide bond synthesis
20. Recognition of cognate transfer RNA by the 30S ribosomal subunit
21. Complete kinetic mechanism of elongation factor Tu-dependent binding of aminoacyl-tRNA to the A site of the E.coli ribosome
22. Induced fit in initial selection and proofreading of aminoacyl-tRNA on the ribosome
23. A functional pseudoknot in 16S ribosomal RNA
24. Pre-steady-state kinetics of ribosomal translocation
25. Codon-dependent conformational change of elongation factor Tu preceding GTP hydrolysis on the ribosome
26. Hydrolysis of GTP by elongation factor G drives tRNA movement on the ribsosome
27. Energetic contribution of tRNA hybrid state formation to translocation catalysis on the ribosome
28. Direct analysis of aminoacylation levels of tRNAs in vivo. Application to studying recognition of Escherichia coli initiator tRNA mutants by glutaminyl-tRNA synthetase
29. The influence of ribosome-binding-site elements on translational efficiency in Bacillus subtilis and Escherichia coli in vivo
30. Mapping the position of translational elongation factor EF-G in the ribosome by directed hydroxyl radical probing
31. Crystal structure of the ribosome at 5.5 Å resolution
32. The path of messenger RNA through the ribosome