Conformational changes in the ribosome induced by translational miscoding agents

Journal of Molecular Biology

Volumn 304, Issue 5, 2000, Pages 707-713

  Jerinic, O ^a   Joseph, S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aminoglycosides; Antibiotics; mRNA; Ribosome; tRNA

Indexed keywords

AMINOGLYCOSIDE; ANTIBIOTIC AGENT; CHLORAMPHENICOL; ERYTHROMYCIN; FUSIDIC ACID; GENTAMICIN; HYGROMYCIN B; KANAMYCIN; MESSENGER RNA; NEOMYCIN; SPECTINOMYCIN; STREPTOMYCIN; TETRACYCLINE; TRANSFER RNA; VIOMYCIN;

ARTICLE; CONFORMATIONAL TRANSITION; DNA FOOTPRINTING; ESCHERICHIA COLI; GENETIC CODE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN STRUCTURE; RIBOSOME; RNA TRANSLATION; STRAIN DIFFERENCE;

EID: 0034671274     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.4269     Document Type: Review

References (37)

1. Interaction of antibiotics with functional sites in 16 S ribosomal RNA
2. Streptomycin binds to the decoding center of 16 S ribosomal RNA
3. Transfer RNA shields specific nucleotides in 16 S ribosomal RNA from attack by chemical probes
4. Binding of tRNA to the ribosomal A and P sites protects two distinct sets of nucleotides in 16 S rRNA
5. Dissociation rate of cognate peptidyl-tRNA from the A-site of hyper-accurate and error-prone ribosomes
6. Selective perturbation of G530 of 16 S rRNA by translational miscoding agents and a streptomycin-dependence mutation in protein S12
7. Conformational switch in the decoding region of 16 S rRNA during aminoacyl-tRNA selection on the ribosome
8. A ribosomal ambiguity mutation
9. Altered ribosomal protein in streptomycin-dependent Escherichia coli
10. Electrophoretic and immunological studies on ribosomal proteins of 100 Escherichia coli revertants from streptomycin dependence
11. Ram ribosomes are defective proofreaders
12. A single base substitution in 16 S ribosomal RNA suppresses streptomycin dependence and increases the frequency of translational errors
13. A ribosomal ambiguity mutation in the 530 loop of E. coli 16 S rRNA
14. Kinetic impairment of restrictive streptomycin-resistant ribosomes
15. Hyper-accurate ribosomes inhibit growth
16. The control of accuracy during protein synthesis in Escherichia coli and perturbations of this control by streptomycin, neomycin, or ribosomal mutations
17. Inhibition of interconversion of ribosomes between forms active and inactive in 30 S subunit functions by aminoglycoside antibiotics
18. Changes in accessibility to chemical modification of Escherichia coli ribosomes induced by streptomycin
19. Comparison of the action of streptomycin and neomycin on the structure of the bacterial ribosome
20. Mutations in ribosomal proteins S4 and S12 influence the higher order structure of 16 S ribosomal RNA
21. Structure of the A site of Escherichia coli 16 S ribosomal RNA complexed with an aminoglycoside antibiotic
22. Paromomycin binding induces a local conformational change in the A-site of 16 S rRNA
23. A conformational switch in Escherichia coli 16 S ribosomal RNA during decoding of messenger RNA
24. Major rearrangements in the 70 S ribosomal 3D structure caused by a conformational switch in 16 S ribosomal RNA
25. Extension inhibition analysis of translation initiation complexes
26. Selection of the initiator tRNA by Escherichia coli initiation factors
27. EF-G-catalyzed translocation of anticodon stem-loop analogs of transfer RNA in the ribosome
28. The inhibition pattern of antibiotics on the extent and accuracy of tRNA binding to the ribosome, and their effect on the subsequent steps in chain elongation
29. The effects of organic solvents on protein biosynthesis and their influence on the amino acid code
30. Phenotype masking and streptomycin dependence
31. Chloramphenicol, erythromycin, carbomycin and vernamycin B protect overlapping sites in the peptidyl transferase region of 23 S ribosomal RNA
32. Resistance to viomycin conferred by RNA of either ribosomal subunit
33. Analysis of rpsD mutations in Escherichia coli. I. Comparison of mutants with various alterations in ribosomal protein S4
34. Genetic analysis of streptomycin dependence in Escherichia coli
35. Suppression activated by streptomycin and related antibiotics in drug sensitive strains
36. Effects of tetracycline and spectinomycin on the tertiary structure of ribosomal RNA in the Escherichia coli 30 S ribosomal subunit