Intracutaneous DNA vaccination with the E8 gene of cottontail rabbit papillomavirus induces protective immunity against virus challenge in rabbits

Journal of Virology

Volumn 76, Issue 13, 2002, Pages 6453-6459

  Hu, Jiafen ^a   Han, Ricai ^a   Cladel, Nancy M ^a   Pickel, Martin D ^a   Christensen, Neil D ^a  

^a PENN STATE CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRPV E8 PEPTIDE; DNA VACCINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; DNA VECTOR; GENE DELIVERY SYSTEM; GENE GUN; GENE INDUCTION; GENETIC CODE; IMMUNITY; IMMUNIZATION; NONHUMAN; OPEN READING FRAME; PAPILLOMA VIRUS; PRIORITY JOURNAL; PROPHYLAXIS; RABBIT; VACCINATION; VIROGENESIS; VIRUS GENE;

ADMINISTRATION, CUTANEOUS; ANIMALS; COTTONTAIL RABBIT PAPILLOMAVIRUS; HYPERSENSITIVITY, DELAYED; ONCOGENE PROTEINS; PAPILLOMA; PAPILLOMAVIRUS INFECTIONS; RABBITS; TUMOR VIRUS INFECTIONS; VACCINATION; VACCINES, DNA; VIRAL PROTEINS; VIRAL VACCINES;

EID: 0036281339     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.13.6453-6459.2002     Document Type: Article

References (49)

1. Immunization with viruslike particles from cottontail rabbit papillomavirus (CRPV) can protect against experimental CRPV infection
2. Localization of bovine papillomavirus type 1 E5 protein to transformed basal keratinocytes and permissive differentiated cells in fibropapilloma tissue
3. Delayed-type hypersensitivity response to human papillomavirus type 16 E6 protein in a mouse model
4. Detection by antibody probes of human papillomavirus type 6 E5 proteins in respiratory papillomata
5. Coincidental expression of E5a and c-jun in human papillomavirus type 6/11-infected condylomata
6. Rabbit oral papillomavirus complete genome sequence and immunity following genital infection
7. Immunization with viruslike particles induces long-term protection of rabbits against challenge with cottontail rabbit papillomavirus
8. The E5 protein of HPV-6, but not HPV-16, associates efficiently with cellular growth factor receptors
9. Mechanisms of cell transformation by papillomavirus E5 proteins
10. Protection against papillomavirus with a polynucleotide vaccine
11. Presentation of the HPV16E7 protein by skin grafts is insufficient to allow graft rejection in an E7-primed animal
12. Immunology of papillomavirus infection
13. Cell state as affecting susceptibility to a virus; enhanced effectiveness of the rabbit papilloma virus on hyperplastic epidermis
14. Characterization of transformation function of cottontail rabbit papillomavirus E5 and E8 genes
15. DNA vaccination prevents and/or delays carcinoma development of papillomavirus-induced skin papillomas on rabbits
16. Protection of rabbits from viral challenge by gene gun-based intracutaneous vaccination with a combination of cottontail rabbit papillomavirus E1, E2, E6, and E7 genes
17. Intramuscular injection of plasmid DNA encoding cottontail rabbit papillomavirus E1, E2, E6 and E7 induces T cell-mediated but not humoral immune responses in rabbits
18. Immunization of rabbits with cottontail rabbit papillomavirus E1 and E2 genes: Protective immunity induced by gene gun-mediated intracutaneous delivery but not by intramuscular injection
19. Transforming properties of the cottontail rabbit papillomavirus oncoproteins LE6 and SE6 and of the E8 protein
20. Spontaneous regression of CIN and delayed-type hypersensitivity to HPV-16 oncoprotein E7
21. Skin test for HPV type 16 proteins in cervical intraepithelial neoplasia
22. Skin test to assess immunity against cottontail rabbit papillomavirus antigens in rabbits with progressing papillomas or after papilloma regression
23. Vaccination with yeast-expressed cottontail rabbit papillomavirus (CRPV) virus-like particles protects rabbits from CRPV-induced papilloma formation
24. Recombinant Listeria monocytogenes vaccination eliminates papillomavirus-induced tumors and prevents papilloma formation from viral DNA
25. Detection of E5 oncoprotein in human papillomaviros type 16-positive cervical scrapes using antibodies raised to synthetic peptides
26. Virus-like particles of bovine papillomavirus type 4 in prophylactic and therapeutic immunization
27. The Shope papilloma-carcinoma complex of rabbits: A model system of neoplastic progression and spontaneous regression
28. High efficiency induction of papillomas in vivo using recombinant cottontail rabbit papillomavirus DNA
29. Vaccination against polyomaand papillomavirus-induced tumors using vaccinia recombinants expressing non-structural proteins
30. Granulocyte-macrophage colony-stimulating factor priming plus papillomavirus E6 DNA vaccination: Effects on papilloma formation and regression in the cottontail rabbit papillomavirus-rabbit model
31. Cottontail rabbit papillomavirus L1 protein-based vaccines: Protection is achieved only with a full-length, nondenatured product
32. Effective vaccination against papilloma development by immunization with L1 or L2 structural protein of cottontail rabbit papillomavirus
33. Induction of CD8 T cells by vaccination with recombinant adenovirus expressing human papillomavirus type 16 E5 gene reduces tumor growth
34. DNA vaccines
35. The immunology of animal papillomaviruses
36. Cancer vaccines
37. Golgi alkalinization by the papillomavirus E5 oncoprotein
38. Tumor regression is associated with a specific immune response to the E2 protein of cottontail rabbit papillomavirus
39. Immunization with nonstructural proteins E1 and E2 of cottontail rabbit papillomaviros stimulates regression of virus-induced papillomas
40. + cells and persistence of viral DNA after regression
41. Intra-epithelial vaccination with COPV L1 DNA by particle-mediated DNA delivery protects against mucosal challenge with infectious COPV in beagle dogs
42. Intracutaneous vaccination of rabbits with the cottontail rabbit papillomavirus (CRPV) L1 gene protects against virus challenge
43. Intracutaneous vaccination of rabbits with the E6 gene of cottontail rabbit papillomavirus provides partial protection against virus challenge
44. Systemic immunization with papillomavirus L1 protein completely prevents the development of viral mucosal papillomas
45. Genetic immunization is a simple method for eliciting an immune response
46. DNA vaccines
47. High efficiency, long-term clinical expression of cottontail rabbit papillomavirus (CRPV) DNA in rabbit skin following particle-mediated DNA transfer
48. E5 protein of human papillomavirus type 16 protects human foreskin keratinocytes from UV B-irradiation-induced apoptosis
49. Papillomaviruses causing cancer: Evasion from host-cell control in early events in carcinogenesis