E5 protein of human papillomavirus type 16 protects human foreskin keratinocytes from UV B-irradiation-induced apoptosis

Journal of Virology

Volumn 76, Issue 1, 2002, Pages 220-231

  Zhang, B ^a   Spandau, D F ^a   Roman, A ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG; VIRUS E5 PROTEIN; VIRUS PROTEIN; WORTMANNIN;

APOPTOSIS; ARTICLE; CELL PROTECTION; CELL STIMULATION; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; KERATINOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; RETROVIRUS; SIGNAL TRANSDUCTION; ULTRAVIOLET B RADIATION; VIRUS RECOMBINANT; WART VIRUS;

APOPTOSIS; CELL SURVIVAL; DOWN-REGULATION; EPIDERMAL GROWTH FACTOR; HUMANS; KERATINOCYTES; ONCOGENE PROTEINS, VIRAL; PAPILLOMAVIRIDAE; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; ULTRAVIOLET RAYS;

EID: 0036132827     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.1.220-231.2002     Document Type: Article

References (94)

1. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase in vitro and in vivo
2. Ultraviolet light induces apoptosis via direct activation of CD95 (Fas/APO-1) independently of its ligand CD95L
3. p53 inhibits 6β4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB
4. Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines
5. The activation of p38 and apaptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase/Akt pathway
6. Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
7. Activation of p42/p44 mitogen-activated protein kinases (MAPK) and p38 MAPK by tumor necrosis factor (TNF) is mediated through the death domain of the 55-kDa TNF receptor
8. Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion
9. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
10. DNA sequence of the HPV-16 E5 ORF and the structural conservation of its encoded protein
11. Reversible G1 arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27 (KIP1) independent of MAPK activity
12. Wavelength specific patterns of p53 induction in human skin following exposure to UV radiation
13. Three paths to stress relief
14. Regulation of cell death protease caspase-9 by phosphorylation
15. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation
16. Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases
17. Functional complementation of the adenovirus E1B 19-kilodalton protein with Bcl-2 in the inhibition of apoptosis in infected cells
18. The human papillomavirus type 6 and 16 E5 are membrane-associated proteins which associate with the 16 kilodalton pore-forming protein
19. Ultraviolet B-radiation dose influences the induction of apoptosis and p53 in human keratinocytes
20. A direct effect of activated human p53 on nuclear DNA replication
21. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
22. Enhancement of EGF- and PMA-mediated MAP kinase activation in cells expressing the human papillomavirus type 16 E5 protein
23. The human papillomavirus type 16 E5-protein modulates ligand-dependent activation of the EGF receptor family in the human epithelial cell line HaCaT
24. Evidence of a role for phosphatidylinositol 3-kinase activation in the blocking of apoptosis by polyomavirus middle T antigen
25. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
26. Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B
27. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene
28. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
29. Papillomavirus E2 induces p53-independent apoptosis in HeLa cells
30. CREB is a regulatory target for the protein kinase Akt/PKB
31. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
32. p38 mitogen-activated protein kinase-dependent and -independent intracellular signal transduction pathways leading to apoptosis in human neutrophils
33. Fibroblast growth factor-2 suppression of tumor necrosis factor α-mediated apoptosis requires Ras and the activation of mitogen-activated protein kinase
34. Epidermal growth factor protects epithelial cells against Fas-induced apoptosis
35. Effect of human papillomavirus type 16 oncogenes on MAP kinase activity
36. Identification of the E5 open reading frame of human papillomavirus type 16
37. High levels of p53 protein in UV-irradiated normal human skin
38. HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes
39. Inhibition of BAD phosphorylation either at serine 112 via extracellular signal-regulated protein kinase cascade or at serine 136 via Akt cascade sensitizes human ovarian cancer cells to cisplatin
40. To die or not to die: An overview of apoptosis and its role in disease
41. Wild-type p53 regulates its own transcription in a cell-type specific manner
42. The HPV-16E5 protein: Expression, detection and stable complex formation with transmembrane proteins in COS cells
43. Apoptosis induced by arsenic trioxide in leukemia U937 cells is dependent on activation of p38, inactivation of ERK and the Ca2+-dependent production of superoxide
44. Immortalization of primary human epithelial cells by cloned cervical carcinoma DNA containing human papillomavirus type 16 E6/E7 open reading frames
45. Detection of E5 oncoprotein in human papilloma virus type 16-positive cervical scrapes using antibodies raised to synthetic peptides
46. Direct control of the Forkhead transcription factor AFX by protein kinase B
47. Antiapoptotic signaling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt
48. Activation of c-Jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK) is critical for hypoxia-induced apoptosis of human malignant melanoma
49. The E5 gene from human papillomavirus type 16 is an oncogene which enhances growth factor-mediated signal transduction to the nucleus
50. Fas/Fas ligand interaction contributes to UV-induced apoptosis in human keratinocytes
51. p53, the cellular gate keeper for growth and division
52. UV-B/A irradiation of mouse keratinocytes results in p53-mediated WAF1/CIP1 expression
53. Susceptibility of HIV-1-TAT transfected cells to undergo apoptosis. Biochemical mechanisms
54. Ultraviolet B irradiation of human leukaemia HL-60 cells,in vitro induces apoptosis
55. Temporal and spatial expression of the E5a protein during the differentiation-dependent life cycle of human papillomavirus type 31b
56. Inactivation and dephosphorylation of protein kinase B alpha (PKB alpha) promoted by hyperosmotic stress
57. Ultrastructural features of fetal erythroid precursors infected with parvovirus B19 in vitro: Evidence of cell death by apoptosis
58. Negative feedback regulation of wild-type p53 biosynthesis
59. The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes
60. The Fas death factor
61. Programmed cell death induced by ceramide
62. Viruses and apoptosis
63. Induction of apoptosis in luteinized granulosa cells by the MAP kinase kinase (MEK) inhibitor PD98059
64. NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase
65. Ultraviolet radiation-induced apoptosis is mediated by activation of CD-95 (Fas/APO-1)
66. Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B
67. Serial cultivation of strains of human epidermal keratinocytes: The formation of keratinizing colonies from single cells
68. NF-kappaB is a target of AKT in anti-apoptotic PDGF signaling
69. Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated; transcriptionally dependent apoptosis
70. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
71. Regulation of Bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase
72. Ultraviolet-B-induced apoptosis of keratinocytes: Evidence for partial involvement of tumor necrosis factor-alpha in the formation of sunburn cells
73. Structure and transcription of human papillomavirus sequences in cervical carcinoma cells
74. Immediate early up-regulation of bax expression by p53 but not TGF beta 1: A paradigm for distinct apoptotic pathways
75. Human papillomavirus type 16 and 18 gene expression in cervical neoplasias
76. The E7 protein of human papillomavirus type 16 sensitizes primary human keratinocytes to apoptosis
77. The E5 oncoprotein of human papillomavirus type 16 inhibits the acidification of endosomes in human keratinocytes
78. The E5 oncoprotein of human papillomavirus type 16 transforms fibroblasts and effects the down-regulation of the epidermal growth factor receptor in keratinocytes
79. Ionizing radiation-induced cell death
80. Interleukin-1beta-converting enzyme and CPP32 are involved in ultraviolet B-induced apoptosis of SV40-transformed human keratinocytes
81. Adenovirus E1A proteins induce apoptosis by both p53-dependent and p53-independent mechanisms
82. Apoptosis in the pathogenesis and treatment of disease
83. The HPV16 E5 oncogene inhibits endocytic trafficking
84. Fluoride-induced apoptosis in epithelial lung cells involves activation of MAP kinases p38 and possibly JNK
85. Abrogation of p53 function by transfection of HPV16 E6 gene enhances the resistance of human diploid fibroblasts to ionizing radiation
86. The human papillomavirus (HPV)-6 and HPV-16 E5 proteins co-operate with HPV-16 E7 in the transformation of primary rodent cells
87. Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB
88. The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway
89. Association of human papillomavirus types 16 and 18 E6 proteins with p53
90. Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells
91. HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-B pathway
92. Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis
93. Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress
94. Human papillomaviruses