The multitalented pore-forming proteins of intracellular pathogens

Microbes and Infection

Volumn 4, Issue 7, 2002, Pages 741-750

  Almeida Campos, Flávia R ^a   Noronha, Fátima S M ^a   Horta, M Fátima ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Apoptosis; Intracellular pathogens; Phagosome escape; Pore forming proteins; Type III secretion apparatus

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 12; INTERLEUKIN 1BETA; MICROORGANISM PROTEIN; PORE PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; AEROMONAS HYDROPHILA; BACILLUS ANTHRACIS; BACILLUS SUBTILIS; BORDETELLA; BRUCELLA; CELL INVASION; CHLAMYDIA; COXIELLA; CYTOKINE PRODUCTION; ESCHERICHIA COLI; HOST CELL; IMMUNE SYSTEM; INFLAMMATION; LEGIONELLA PNEUMOPHILA; LEISHMANIA; LISTERIA MONOCYTOGENES; MYCOBACTERIUM; NONHUMAN; PATHOGENESIS; PHAGOCYTOSIS; PHAGOSOME; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN FUNCTION; PSEUDOMONAS AERUGINOSA; REVIEW; RICKETTSIA; SALMONELLA; SHIGELLA; STAPHYLOCOCCUS AUREUS; TOXOPLASMA GONDII; TRYPANOSOMA CRUZI; YERSINIA ENTEROCOLITICA;

ANIMALS; APOPTOSIS; BACTERIA; BACTERIAL INFECTIONS; HOST-PARASITE RELATIONS; MODELS, BIOLOGICAL; PHAGOCYTOSIS; PORINS; PROTOZOA; PROTOZOAN INFECTIONS;

EID: 0036279755     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1286-4579(02)01593-9     Document Type: Review

References (60)

1. Mechanisms of survival of protozoan parasites in mononuclear phagocytes
2. Evasion of host cell defense mechanisms by pathogenic bacteria
3. Cytolysins and the intracellular life of bacteria
4. Pore-forming proteins in pathogenic protozoan parasites
5. Mechanism of Shigella entry into epithelial cells
6. The tripartite type III secreton of Shigella flexneri inserts IpaB and IpaC into host membranes
7. Bacterial signals and cell responses during Shigella entry into epithelial cells
8. Diversion of cytoskeletal processes by Shigella during invasion of epithelial cells
9. Insertion of a Yop translocation pore into the macrophage plasma membrane by Yersinia enterocolitica: Requirement for translocators YopB and YopD, but not LcrG
10. The YopB protein of Yersinia pseudotuberculosis is essential for the translocation of Yop effector proteins across the target cell plasma membrane and displays a contact-dependent membrane disrupting activity
11. Molecular and cell biology aspects of plague
12. YopE of Yersinia, a GAP for Rho GTPases, selectively modulates Rac-dependent actin structures in endothelial cells
13. YopT, a new Yersinia Yop effector protein, affects the cytoskeleton of host cells
14. Salmonella pathogenicity islands encoding type III secretion systems
15. SopE, a secreted protein of Salmonella dublin, is translocated into the target eukaryotic cell via a sip-dependent mechanism and promotes bacterial entry
16. The invasion-associated type III system of Salmonella typhimurium directs the translocation of Sip proteins into the host cell
17. The Salmonella type III secretion translocon protein SspC is inserted into the epithelial cell plasma membrane upon infection
18. Functional conservation of the Salmonella and Shigella effectors of entry into epithelial cells
19. Salmonella typhimurium secreted invasion determinants are homologous to Shigella Ipa proteins
20. Functional conservation of the effector protein translocators PopB/YopB and PopD/YopD of Pseudomonas aeruginosa and Yersinia pseudotuberculosis
21. Pseudomonas aeruginosa exoenzyme S, a bifunctional type-III secreted cytotoxin
22. Multiple domains are required for the toxic activity of Pseudomonas aeruginosa ExoU
23. Intracellular targeting of exoenzyme S of Pseudomonas aeruginosa via type III-dependent translocation induces phagocytosis resistance, cytotoxicity and disruption of actin microfilaments
24. The arginine finger domain of ExoT contributes to actin cytoskeleton disruption and inhibition of internalization of Pseudomonas aeruginosa by epithelial cells and macrophages
25. Adenylate cyclase toxin from Bordetella pertussis: Current concepts and problems in the study of toxin function
26. Characterization and functional analysis of PorB, a Chlamydia porin and neutralizing target
27. Bacillus subtilis expressing a haemolysin gene from Listeria monocytogenes can grow in mammalian cells
28. Role of listeriolysin O in cell-to-cell spread of Listeria monocytogenes
29. The two distinct phospholipases C of Listeria monocytogenes have overlapping roles in escape from a vacuole and cell-to-cell spread
30. Bacterial replication in the host cell cytosol
31. Mutagenesis of active-site histidines of Listeria monocytogenes phosphatidylinositol-specific phospholipase C: Effects on enzyme activity and biological function
32. Listeriolysin is processed efficiently into an MHC class I-associated epitope in Listeria monocytogenes-infected cells
33. PH-dependent perforation of macrophage phagosomes by listeriolysin O from Listeria monocytogenes
34. A PEST-like sequence in listeriolysin O essential for Listeria monocytogenes pathogenicity
35. The secreted IpaB and IpaC invasins and their cytoplasmic chaperone IpgC are required for intercellular dissemination of Shigella flexneri
36. Intracellular Staphylococcus aureus escapes the endosome and induces apoptosis in epithelial cells
37. Cytolysins from intracellular pathogens
38. Actinobacillus actinomycetemcomitans leukotoxin forms large conductance, voltage-gated ion channels when incorporated into planar lipid bilayers
39. PH and calcium dependence of hemolysis due to Rickettsia prowazekii: Comparison with phospholipase activity
40. Pore size of the malaria parasite's nutrient channel
41. The parasitophorous vacuole membrane surrounding intracellular Toxoplasma gondii functions as a molecular sieve
42. Cell biology of Legionella pneumophila
43. Temporal pore formation-mediated egress from macrophages and alveolar epithelial cells by Legionella pneumophila
44. Legionella pneumophila entry gene rtxA is involved in virulence
45. Kwaik, icmT is essential for pore formation-mediated egress of Legionella pneumophila from mammalian and protozoan cells
46. Identification of a putative pore-forming hemolysin active at acid pH in Leishmania amazonensis
47. Cytolytic activity in the genus Leishmania: Involvement of a putative pore-forming protein
48. Macrophage damage by Leishmania amazonensis cytolysin: Evidence of pore formation
49. Proteolytic activation of leishporin: Evidence that Leishmania amazonensis and Leishmania guyanensis have distinct inactive forms
50. Pathogen-induced apoptosis of macrophages: A common end for different pathogenic strategies
51. Growth phase-regulated induction of Salmonella-induced macrophage apoptosis correlates with transient expression of SPI-1 genes
52. Hijacking of apoptotic pathways by bacterial pathogens
53. Apoptosis induced by Staphylococcus aureus in epithelial cells utilizes a mechanism involving caspases 8 and 3
54. Neisserial porin (PorB) causes rapid calcium influx in target cells and induces apoptosis by the activation of cysteine proteases
55. Macrophage damage and interleukin-1 production in murine macrophages exposed to listeriolysin O
56. Induction of cytokine gene expression by listeriolysin O and roles of macrophages and NK cells
57. Intracytoplasmic delivery of listeriolysin O by a vaccinal strain of Bacillus anthracis induces CD8-mediated protection against L. monocytogenes
58. The cytotoxic enterotoxin of Aeromonas hydrophila induces proinflammatory cytokine production and activates arachidonic acid metabolism in macrophages
59. Presentation of Listeria monocytogenes to CD8+ T cells requires secretion of hemolysin and intracellular bacterial growth
60. Anthrax toxin fusion proteins for intracellular delivery of macromolecules