Reinjection of ex vivo-expanded primate bone marrow mononuclear cells strongly reduces radiation-induced aplasia

Journal of Hematotherapy and Stem Cell Research

Volumn 11, Issue 3, 2002, Pages 549-564

  Bertho, Jean Marc ^a,c   Frick, Johanna ^a,c   Demarquay, Christelle ^a   Lauby, Armelle ^a   Mathieu, Emilie ^a   Dudoignon, Nicolas ^a   Jacquet, Nelly ^a   Trompier, François ^b   Chapel, Alain ^a   Joubert, Christophe ^a   Lopez, Manuel ^c   Aigueperse, Jocelyne ^a   Gorin, Norbert Claude ^c   Gourmelon, Patrick ^a,c   Thierry, Dominique ^a,c  

^a INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE IRSN   (France)

^b Service de Dosimétrie Externe   (France)

^c HÔPITAL SAINT ANTOINE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

COBALT 60; CYTOKINE; FLT3 LIGAND; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 6; MONOCLONAL ANTIBODY; RECOMBINANT INTERLEUKIN 3; RECOMBINANT STEM CELL FACTOR; THROMBOPOIETIN;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BONE MARROW APLASIA; BONE MARROW CELL; COBALT THERAPY; COLONY FORMING UNIT; CONTROLLED STUDY; FIBROBLAST; IRRADIATION; MACACA; MALE; MONONUCLEAR CELL; NONHUMAN; PRIMATE; PRIORITY JOURNAL; RADIATION INJURY; WHOLE BODY RADIATION;

ANIMALS; BONE MARROW CELLS; CELL CULTURE TECHNIQUES; LEUKOCYTE COUNT; LEUKOCYTES, MONONUCLEAR; MACACA FASCICULARIS; MALE; MEMBRANE PROTEINS; PANCYTOPENIA; TIME FACTORS; TRANSPLANTATION, AUTOLOGOUS; TREATMENT OUTCOME; WHOLE-BODY IRRADIATION;

EID: 0036273698     PISSN: 15258165     EISSN: None     Source Type: Journal    
DOI: 10.1089/15258160260091013     Document Type: Article

References (47)

1. + cells and unseparated peripheral blood progenitor cells mediate identical hematopoietic engraftment after high-dose VP16, lfosfamide, carboplatin, and Epirubicin
2. + cells
3. Ex vivo expansion of hematopoietic precursors, progenitors and stem cells: The next generation of cellular therapeutics
4. Ex vivo expansion of hematopoietic stem and progenitor cells: Are we there yet?
5. Progress in the development of systems for in vitro expansion of human hematopoietic stem cells
6. Ex vivo expansion of hematopoietic progenitor cells for clinical use
7. - hematopoietic cells
8. Ex vivo expanded peripheral blood progenitor cells provide rapid neutrophil recovery after high-dose chemotherapy in patients with breast cancer
9. + cells with porcine microvascular endothelial cells results in a graft capable of rescuing lethally irradiated baboons
10. + cells accelerate haematological recovery in a baboon model of autologous transplantation
11. Abrogation of post-myeloablative chemotherapy neutropenia by ex-vivo expansion autologous CD34-positive cells
12. Presence of primitive lymphoid progenitors with NK or B potential in ex vivo expanded bone marrow cell cultures
13. + cord blood cells
14. Mesenchymal stem cells: Biology and potential applications
15. Rapid hematopoietic recovery after coinfusion of autologousblood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy
16. Cotransplantation of human stromal cell progenitors into preimmune fetal sheep results in early appearance of human donor cells in circulation and boosts cell levels in bone marrow at later time points after transplantation
17. Cell culture bags allow a large extent of ex vivo expansion of LTC-IC and functional mature cells which can subsequently be frozen: Interest for large-scale clinical applications
18. Flt3 ligand, MGDF, Epo and G-CSF enhance ex vivo expansion of hematopoietic cell compartments in the presence of SCF, IL-3 and IL-6
19. Evaluation of some parameters influencing the ex vivo expansion of non-human primate bone marrow mononucleated cells
20. Species specificity of human interleukin-3 demonstrated by cloning and expression of homologous rhesus monkey (Macaca mulatta) gene
21. A rapid method for measuring apoptosis and dual-color immunofluorescence by single laser flow cytometry
22. Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny
23. Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers
24. - progenitor cells in long-term cultures and semi-solid assays
25. Dosimetry for total body irradiation of rhesus monkeys with 300 kV X-rays
26. Chromosome lesions as a short and medium term biological indicator of acute irradiation
27. Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies
28. Level of Flt3-1igand in plasma: A possible new bio-indicator for radiation-induced aplasia
29. The in vitro and in vivo effects of stem cell factor on human hematopoiesis
30. + hematopoietic progenitor cells
31. + cell selection in stroma-free cultures
32. Long-term culture-initiating cell expansion is dependent on frequent medium exchange combined with stromal and other accessory cell effects
33. Self-renewal of primitive human hematopoietic cells (long-term-culture-initiating cells) in vitro and their expansion in defined medium
34. A clinically suitable ex vivo expansion system for LTC-IC and CFC using stroma-conditioned medium
35. How many myeloid post-progenitor cells have to be transplanted to completely abrogate neutropenia after peripheral blood progenitor cell transplantation? Results of a computer simulation
36. Ex vivo expanded unselected peripheral blood: Progenitor cells reduce posttransplantation neutropenia, thrombocytopenia, and anemia in patients with breast cancer
37. Large-scale expansion of human stem and progenitor cells from bone marrow mononuclear cells in continuous perfusion cultures
38. Role of mesenchymal stem cells in hematopoietic stem cell transplantation
39. Mesenchymal stem cells are capable of homing to the bone marrow of non-human primates following systemic infusion
40. Multilineage potential of adult human mesenchymal stem cells
41. Soluble factor(s) produced by human bone marrow stroma increase cytokine induced proliferation and maturation of primitive hematopoietic progenitors while preventing their terminal differentiation
42. Blood cell kinetics and total body irradiation
43. Flt3 ligand levels reflects hematopoietic progenitor cell function in aplastic anemia and chemotherapy-induced bone marrow aplasia
44. + cells in autologous stem cell transplantation for breast cancer
45. CD34-positive cells isolated from cryopreserved peripheral blood progenitor cells can be expanded ex vivo and used for transplantation with little or no toxicity
46. Ex-vivo expansion of bone marrow progenitor cells for hematopoietic reconstitution following high-dose chemotherapy for breast cancer
47. + progenitor cells expanded in G-CSF, SCF and MGDF decreases the duration and severity of neutropenia