Ex-vivo expansion of bone marrow progenitor cells for hematopoietic reconstitution following high-dose chemotherapy for breast cancer

Experimental Hematology

Volumn 27, Issue 4, 1999, Pages 615-623

  Bachier, Carlos R ^a   Gokmen, Erhan ^b   Teale, Judy ^b   Lanzkron, Sophie ^a   Childs, Craig ^a   Franklin, Wilbur ^c   Shpall, Elizabeth ^c   Douville, Judith ^d   Weber, Stephanie ^d   Muller, Thomas ^d   Armstrong, Douglas ^d   Lemaistre, Charles F ^a  

^a South Texas Genetics Center   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d Aastrom Biosciences Inc   (United States)

Author keywords

Ex vivo expansion; Growth factors; Stem cell transplant

Indexed keywords

CISPLATIN; CYCLOPHOSPHAMIDE; ERYTHROPOIETIN; FLT3 LIGAND; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEMOPOIETIC GROWTH FACTOR; INTERLEUKIN 3;

ADULT; ARTICLE; BONE MARROW BIOPSY; BONE MARROW CELL; BREAST CANCER; CANCER IMMUNOTHERAPY; CANCER STAGING; CLINICAL ARTICLE; COLONY FORMING UNIT GM; DOSE RESPONSE; DRUG MEGADOSE; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; NEUTROPHIL CHEMOTAXIS; PRIORITY JOURNAL; STEM CELL TRANSPLANTATION;

ADULT; ANTINEOPLASTIC AGENTS; BODY WEIGHT; BREAST NEOPLASMS; CELL DIVISION; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; LYMPHOCYTE COUNT; LYMPHOCYTE SUBSETS; MIDDLE AGED; RECURRENCE; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, AUTOLOGOUS; TREATMENT OUTCOME;

STAPHYLOCOCCUS PHAGE 187;

EID: 0032937050     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(98)00085-X     Document Type: Article

References (42)

1. Kessinger A., Armitage J.O., Landmark J.D., Smith D.M., Weisenburger D. Autologous peripheral hematopoietic stem cell transplantation restores hematopoietic function following marrow ablative therapy. Blood. 71:1988;723.
2. Juttner C.A., To L.B., Ho J.Q., Bardy P.G., Dyson P.G. Early lymphohematopoietic recovery after autografting using peripheral blood stem cells in acute nonlymphoblastic leukemia. Transplant Proc. 20:1988;40.
3. Sheridan W., Begley C.G., Juttner C.A., Szer J., To L.B. Effect of peripheral blood progenitor cells mobilized by filgrastim (G-CSF) on platelet recovery after high dose chemotherapy. Lancet. 1:1992;640.
4. Juttner C.A., To L.B., Roberts M.M., Haylock D., Dyson P.G. Comparison of hematologic recovery, toxicity, and supportive care of autologous PBSC, autologous BM, and allogeneic BM transplants. Int J Cell Cloning. 10:1992;160.
5. Ager S., Scott M.A., Magendra P. Peripheral blood stem cell transplantation after high dose chemotherapy in patients with malignant lymphoma. a retrospective comparison with autologous bone marrow transplantation Bone Marrow Transplant. 16:1995;79.
6. Schmitz N., Linch D.C., Dreger P. Randomized trial of filgrastim-mobilized peripheral progenitor cell transplantation versus autologous bone-marrow transplantation in lymphoma patients. Lancet. 347:1996;353.
7. Alexander H.R. Vascular access and other specialized techniques of drug delivery. Devita V.T., Hellman S., Rosenberg S.A. Cancer. Principles and Practice of Oncology:1993;JB Lippincott Co, Philadelphia.
8. Gribben J., Neuberg D., Freedman A., Gimmi C., Pesek K., Barber M., Saporito L., Woo S., Coral F., Spector N., Rabinowe S., Grossbard B., Ritz J., Nadler L. Detection by polymerase chain reaction of residual cells with the bcl-2 translocation is associated with increased risk of relapse after autologous bone marrow transplantation for B-cell lymphoma. Blood. 81:1993;3449.
9. Brugger W., Bross K.J., Glatt M., Weber F., Mertelsmann R., Kanz L. Mobilization of tumor cells and hematopoietic progenitor cells into peripheral blood of patients with solid tumors. Blood. 83:1994;636.
10. Vredenburgh J., Silva O., de Sombre K., Tyer K., Abou-Ghalia A., Cook M., Layfielld L., Peters W.P., Bast R.C. A comparison of immunohistochemistry, two-color immunofluorescence, and flow cytometry with cell sorting for the detection of micrometastasic breast cancer in the bone marrow. J Hematotherapy. 5:1996;57.
11. Brockstein B.E., Ross A.A., Moss T.J., Kahn D.G., Hollingsworth K., Williams S.F. Tumor cell contamination of bone marrow harvest products. clinical consequences in a cohort of advanced-stage breast cancer patients undergoing high-dose chemotherapy J Hematother. 6:1996;617.
12. Vredenburgh J.J., Silva O., Broadwater G., Berry D., DeSombre K., Tyer C., Petros W.P., Peters W.P., Bast R.C. The significance of tumor contamination in the bone marrow from high risk primary breast cancer patients treated with high dose chemotherapy and hematopoietic support. Biol Blood Marrow Transplant. 3:1997;91.
13. Schulze R., Schulze M., Wischnik A., Ehnle S., Doukas K., Behr W., Ehret W., Schlimok G. Tumor contamination of peripheral blood stem cell transplants and bone marrow in high risk breast cancer patients. Bone Marrow Transplant. 12:1997;1223.
14. Henschler R., Brugger W., Luft T., Frey R., Mertelsmann R., Kanz L. Maintenance of transplantation potential in ex-vivo expanded CD34+-selected human peripheral blood progenitor cells. Blood. 84:1994;2898.
15. Sandstrom C., Bender J., Papoutsakis E., Miller W. Effects of CD 34+ cell selection and perfusion on ex vivo expansion of peripheral blood mononuclear cells. Blood. 86:1995;958.
16. Smith S., Bender J., Maples P. Expansion of neutrophil precursors and progenitors in suspension cultures of CD 34+ cells enriched from human bone marrow. Exp Hematol. 21:1993;870.
17. Lill M., Lynch M., Fraser J. Production of functional myeloid cell from CD34-selected hematopoeitic progenitor cells using a clinically relevant ex vivo expansion system. Stem Cells. 12:1994;626.
18. Sato M., Sawada K., Koizumi K. In vitro expansion of human peripheral blood CD34+ cells. Blood. 82:1993;3600.
19. Brugger W., Heimfeld S., Berenson F., Merstelsmann R., Kanz L. Reconstitution of hematopoiesis after high dose chemotherapy by autologous progenitor cells generated ex-vivo. N Engl J Med. 333:1995;283.
20. Haylock D., To L., Dowse T., Juttner C., Simmons P. Ex vivo expansion and maturation of peripheral blood CD 34+ cells into the myeloid lineage. Blood. 80:1992;1405.
21. Shapiro F., Yao T., Raptis G., Reich L., Norton L., Moore M. Optimization of conditions for ex vivo expansion of CD34+ cells from patients with Stage IV breast cancer. Blood. 84:1994;3567.
22. Sandstrom C., Bender J., Miller W., Papoutsakis E. Comparison of perfused and static peripheral blood cell cultures with and without stroma using a modified culture chamber for non-adherent cell retention. Biotech Bioeng. 50:1996;493.
23. Udomsakdi C., Eaves C., Swolin B., Teid D., Barnett M., Eaves A. Rapid decline of chronic myeloid leukemic cells in long-term culture due to a defect at the leukemic stem cell level. Proc Natl Acad Sci USA. 89:1992;6192.
24. Koller M., Emerson S., Palsson B. Large-scale expansion of human stem cell and progenitor cells from bone marrow mononuclear cells in continuous perfusion cultures. Blood. 82:1993;378.
25. Koller M., Palsson B., Manchel I., Palsson B. Long-term culture initiating cell expansion is dependent on frequent medium exchange combined with stromal and other accessory cell effects. Blood. 86:1995;1784.
26. Champlin R.E., Mehra R., Gajewski J. Ex-vivo expanded progenitor cell transplantation in patients with breast cancer. Blood. 86:1995;295a.
27. Franklin W.A., Shpall E.J., Archer P., Johnston C.S., Garza-Williams S., Hami L., Bitter M.A., Bast R.C., Jones R.B. Immunocytochemical detection of breast cancer in marrow and peripheral blood of patients undergoing high dose chemotherapy with autologous stem cell support. Breast Cancer Res Treat. 41:1996;1.
28. Sanders M.E., Makgoba M.W., Shaw S. Human naive and memory T cells. Immunol Today. 9:1998;195.
29. Swain S.L., Craft M., Dubey C., Haynes L., Rogers P., Zhang X., Bradley L.M. From naive to memory T cells. Immunol Rev. 150:1996;142.
30. Atkinson K. Reconstitution of the haemopoietic and immune systems after bone marrow transplantation. Bone Marrow Transplant. 5:1990;209.
31. Store J., Ehitherspoon R.P., Storb J. T cell reconstitution after bone marrow transplantation into adult patients does not resemble T cell development in early life. Bone Marrow Transplant. 16:1995;413.
32. Koehne G., Zeller W., Stockschlaeder M., Zander A.R. Phenotype lymphocyte subsets after autologous peripheral blood stem cell transplantation. Bone Marrow Transplant. 19:1997;149.
33. Talmadge J.E., Reed E., Ino K., Kessinger A., Kunszyski C., Heimann D., Varney M., Jackson J., Vose J.M., Bierman P.J. Rapid immunologic reconstitution following transplantation with mobilized peripheral blood stem cells as compared to bone marrow. Bone Marrow Transplant. 19:1997;161.
34. Stiff P., Oldenberg D., His E., Chen B., Smith A., Bayer R., Malhotra D., Kerger C., Armstrong R.D., Muller T. Transplantation of ex vivo expanded cells grown in Aastrom stromal-based perfusion bioreactors from small marrow aliquots (40 ml) produces durable hematopoietic reconstitution after ablative chemotherapy. Blood. 90:1997;395a.
35. Lundell B.I., Vredenburgh J.J., Tyer C., DeSombre K., Smith A.K. Ex-vivo perfusion culture expansion tumor positive bone marrow from breast cancer patients results in passive purging during the culture period. Blood. 90:1997;216a.
36. Namikawa R., Muench M.O., de Vries J.E., Roncarob M.G. The Flk2/Flt3 Ligand synergies with Interleukin-7 in promoting stromal-cell-independent expansion and differentiation of human fetal pro-B cells in-vitro. Blood. 87:1996;1881.
37. Pribyl J.R., Dittel B.N., LeBien T.W. In-vitro studies of human B lymphopoiesis. Ann NY Acad Sci. 764:1995;9.
38. Ito M., Anan K., Misawa M., Kai S., Hara H. In vitro differentiation of murine sca-1+lin- cells into myeloid, B cells and T cell lineages. Stem Cells. 14:1996;412.
39. Roux E., Helg C., Dumont-Girard F., Chapuis B., Jeannet M., Roosnek E. Analysis of T-cell repopulation after allogeneic bone marrow transplantation. significant differences between recipients of T-cell depleted and unmanipulated grafts Blood. 87:1996;3984.
40. Mackall C., Granger L., Sheard M.A., Cepeda R., Gress R.E. T-cell regeneration after bone marrow transplantation. differential CD45 isoform expression on thymic-derived versus thymic-independent progeny Blood. 82:1993;2585.
41. Heitger A., Neu N., Kern H., Panzer-Grumayer E.R., Greinidx H., Nachbaur D., Niederwieser Fink F.M. Essential role of the thymus to reconstitute naïve (CD45RA+) T-helper cells after human allogeneic bone marrow transplantation. Blood. 90:1997;850.
42. Gokmen E., Raaphorst F.M., Bachier C., LeMaistre C.F., Boldt D.H., Teale J.M. B- and T-cells obtained from ex-vivo expanded bone marrow mononuclear cell transplant recipients exhibit Ig H and TCR Vβ CDR3 repertoires similar to that seen after conventional hematopoietic stem cell transplantation. Blood. 90:1997;539a.