Role of a synthetic pyrimidine compound, MS-818, in reduction of infarct size and amelioration of sensorimotor dysfunction following permanent focal cerebral ischemia in rats

Journal of Neurosurgery

Volumn 96, Issue 6, 2002, Pages 1072-1076

  Mitsuyama, Tetsuryu ^a   Kawamata, Takakazu ^a   Yamane, Fumitaka ^a   Awaya, Akira ^a   Hori, Tomokatsu ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Cerebral ischemia; Infarct volume; MS 818; Pyrimidine derivative; Rat; Sensorimotor function

Indexed keywords

2 PIPERADINO 6 METHYL 5 OXO 5,6 DIHYDRO(7H)PYRROLO[3,4 D]PYRIMIDINE MALEATE; MS 818; PYRIMIDINE; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; BRAIN INFARCTION; BRAIN ISCHEMIA; CONTROLLED STUDY; MALE; NERVE CELL DIFFERENTIATION; NERVE GROWTH; NERVE REGENERATION; NONHUMAN; PRIORITY JOURNAL; SENSORIMOTOR FUNCTION; SUPEROVULATION;

EID: 0036263121     PISSN: 00223085     EISSN: None     Source Type: Journal    
DOI: 10.3171/jns.2002.96.6.1072     Document Type: Article

References (25)

1. Neurotropic pyrimidine heterocyclic compounds. I. The newly synthesized pyrimidine compounds promote neurite outgrowth of GOTO and neuro 2a neuroblastoma cell lines, and potentiate nerve growth factor (NGF)-induced neurite sprouting of PC 12 cells
2. Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: Correlation with suppression of endonuclease activity
3. Rat middle cerebral artery occlusion: Evaluation of the model and development of a neurologic examination
4. Neocortical localization of tactile/proprioceptive limb placing reactions in the rat
5. Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats
6. A synthesized pyrimidine compound, MS-818, promotes walking function recovery from crush injury of the sciatic nerve through its indirect stimulation of Schwann cells
7. Automated measurement of infarct size with scanned images of triphenyltetrazolium chloride-stained rat brains
8. Differential activation of MAPK/ERK and p38/SAPK in neurones and glia following focal cerebral ischaemia in the rat
9. The effect of neurotrophic pyrimidine heterocyclic compounds, MS-818 and MS-430, on the regeneration of injured peripheral nerves
10. The effect of MS-818, a pyrimidine compound, on the regeneration of peripheral nerve fibers of mice after a crush injury
11. Intracisternal basic fibroblast growth factor (bFGF) enhances behavioral recovery following focal cerebral infarction in the rat
12. Intracisternal basic fibroblast growth factor enhances functional recovery and up-regulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction
13. Intracisternal antisense oligonucleotide to growth associated protein-43 blocks the recovery-promoting effects of basic fibroblast growth factor after focal stroke
14. The role of polypeptide growth factors in recovery from stroke
15. Neurotropic pyrimidine heterocyclic compounds. II. Effects of novel neurotropic pyrimidine derivatives on astrocytic morphological differentiation
16. SB 239063, a novel p38 inhibitor, attenuates early neuronal injury following ischemia
17. Enhancement of number of ovulations by administration of a pyrimidine compound with potentiating activity of angiogenesis in mice super-ovulated by PMSG and hCG
18. A neuroprotective compound, aurin tricarboxylic acid, stimulates the tyrosine phosphorylation cascade in PC 12 cells
19. Carbachol stimulates a different phospholipid metabolism than nerve growth factor and basic fibroblast growth factor in PC 12 cells
20. A novel neurotrophic pyrimidine compound MS-818 enhances neurotrophic effects of basic fibroblast growth factor
21. A semiautomated method for measuring brain infarct volume
22. A newly synthesized neurotropic pyrimidine compound, MS-818, may activate migratory schwann cells in peripheral nerve regeneration
23. Pituitary adenylate cyclase-activating polypeptide (PACAP-38) protects cerebellar granule neurons from apoptosis by activating the mitogen-activated protein kinase (MAP kinase) pathway
24. The neurotrophic pyrimidine heterocyclic compound MS- 818 promotes the angiogenesis induced by basic FGF