Intracisternal antisense oligonucleotide to growth associated protein- 43 blocks the recovery-promoting effects of basic fibroblast growth factor after focal stroke

Experimental Neurology

Volumn 158, Issue 1, 1999, Pages 89-96

  Kawamata, Takakazu ^a   Ren, Jingmei ^a   Cha, Jang Ho ^a   Finklestein, Seth P ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Antisense oligonucleotide; Basic fibroblast growth factor; Behavioral recovery; GAP 43; Stroke

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; NEUROMODULIN; RECOMBINANT BASIC FIBROBLAST GROWTH FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INFARCTION; BRAIN REGION; CONTROLLED STUDY; DISEASE COURSE; HISTOPATHOLOGY; MALE; NERVE SPROUTING; NEUROTROPISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; STROKE; TISSUE DISTRIBUTION;

EID: 0032867265     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1999.7101     Document Type: Article

References (25)

1. Aigner L., Arber S., Kapfhammer J. P., Laux T., Schneider C., Botteri F., Brenner H.-R., Caroni P. Overexpression of the neural growth-associated protein GAP-43 induces nerve sprouting in the adult nervous system of transgenic mice. Cell. 83:1995;269-278.
2. Aoyagi A., Nishikawa K., Saito H., Abe K. Characterization of basic fibroblast growth factor-mediated acceleration of axonal branching in cultured rat hippocampal neurons. Brain Res. 661:1994;117-126.
3. Benowitz L. I., Apostolides P. J., Perrone-Bizzozero N., Finklestein S. P., Zwiers H. Anatomical distribution of the growth-associated protein GAP-43/B-50 in the adult rat brain. J. Neurosci. 8:1988;339-352.
4. Benowitz L. I., Rodriguez W., Neve R. L. The pattern of GAP-43 immunostaining changes in the rat hippocampal formation during reactive synaptogenesis. Mol. Brain Res. 8:1990;17-23.
5. Cramer S. C., Nelles G., Benson R. R., Kaplan J. D., Parker R. A., Kwong K. K., Kennedy D. N., Finklestein S. P., Rosen B. R. A functional MRI study of subjects recovered from hemiparetic stroke. Stroke. 28:1997;2518-2527.
6. DeRyck M., Reempts J. v., Duytschaever H., Deuren B. v., Clincke G. Neocortical localization of tactile/proprioceptive limb placing reactions in the rat. Brain Res. 573:1992;44-60.
7. Furie K. L., Oglivy C. S., Smrcka M., Suwanwela N., Can U., Ay H., Cramer S. C., Greenberg S. M., Rordorf G., Finklestein S. P., Foster G. P., Koroshetz W. J., Suwanwela N., Kistler J. P. Cerebrovascular disease. Rosenberg R. N. The Atlas of Clinical Neurology. 1998;Current Medicine, Philadelphia.
8. Jones T. A., Schallert T. Overgrowth and pruning of dendrites in adult rats recovering from neocortical damage. Brain Res. 581:1992;156-160.
9. Jones T. A., Schallert T. Use-dependent growth of pyramidal neurons after neocortical damage. J. Neurosci. 14:1994;2140-2152.
10. Karns L. R., Ng S. C., Freeman J. A., Fishman M. C. Cloning of complementary DNA for GAP-43, a neuronal growth-related protein. Science. 236:1987;597-600.
11. Kawamata T., Alexis N. E., Dietrich W. D., Finklestein S. P. Intracisternal basic fibroblast growth factor (bFGF) enhances behavioral recovery following focal cerebral infarction in the rat. J. Cereb. Blood Flow Metab. 16:1996;542-547.
12. Kawamata T., Dietrich W. D., Schallert T., Gotts J. E., Cocke R. R., Benowitz L. I., Finklestein S. P. Intracisternal basic fibroblast growth factor (bFGF) enhances functional recovery and upregulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction. Proc. Natl. Acad. Sci. USA. 94:1997;8179-8184.
13. Kawamata T., Ren J., Chan T. C. K., Charette M., Finklestein S. P. Intracisternal osteogenic protein-1 enhances functional recovery following focal stroke. NeuroReport. 9:1998;1441-1445.
14. Kawamata T., Schallert T. J., Dietrich W. D., Benowitz L. I., Gotts J. E., Cocke R. R., Finklestein S. P. Intracisternal basic fibroblast growth factor (bFGF) enhances functional recovery and upregulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction. Stroke. 28:1997;250.
15. Kawamata T., Speliotes E. K., Finklestein S. P. The role of polypeptide growth factors in recovery from stroke. Freund H.-J., Sabel B. A., Witte O. W. Brain Plasticity. 1997;377-382 Lippincott-Raven, Philadelphia.
16. Lein P., Johnson M., Guo X., Rueger D., Higgins D. Osteogenic protein-1 induces dendritic growth in rat sympathetic neurons. Neuron. 15:1995;597-605.
17. Nudo R. J., Wise B. M., SiFuentes F., Milliken G. W. Neural substrates for the effects of rehabilitative training on motor recovery after ischemic infarct. Science. 272:1996;1791-1794.
18. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 1986;Academic Press, San Diego.
19. Ren J., Finklestein S. P. Time dependence of infarct reduction by intravenous basic fibroblast growth factor (bFGF) following focal cerebral ischemia in rats. Eur. J. Pharmacol. 327:1997;11-16.
20. Stein C. A., Cheng Y. C. Antisense oligonucleotides as therapeutic agents - "Is the bullet really magical"? Science. 261:1993;1004-1012.
21. Stroemer R. P., Kent T. A., Hulsebosch C. E. Neocortical neural sprouting, synaptogenesis, and behavioral recovery after neocortical infarction in rats. Stroke. 26:1995;2135-2144.
22. Swanson R. A., Morton M. T., Tsao-Wu G., Savalos R. A., Davidson C., Sharp F. R. A semiautomated method for measuring brain infarct volume. J. Cereb. Blood Flow Metab. 10:1990;290-293.
23. Vaudano E., Campbell G., Anderson P. N., Davies A. P., Woolhead C., Schreyer D. J., Lieberman A. R. The effects of a lesion or a peripheral nerve graft on GAP-43 upregulation in the adult rat brain: An in situ hybridization and immunocytochemical study. J. Neurosci. 15:1995;3594-3611.
24. Weiller C., Ramsay S., Wise R. J., Friston K. J., Frackowiak R. S. Individual patterns of functional reorganization in the human cerebral cortex after capsular infarction. Ann. Neurol. 33:1993;181-189.
25. Yankner B. A., Benowitz L. I., Villa-Komaroff L., Neve R. L. Transfection of PC12 cells with the human GAP-43 gene: Effects on neurite outgrowth and regeneration. Mol. Brain Res. 7:1990;39-44.