Differential effects of genistein on cell proliferation, cyclin B1, and p34cdc2 in transformed and nontransformed human breast cells

Pharmaceutical Biology

Volumn 40, Issue SUPPL., 2002, Pages 35-42

  Singletary, Keith W ^a   Frey, Randall S ^a   Li, Jiyuan Y ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Cell cycle; Cyclin B1; Genistein; P34cdc2

Indexed keywords

CYCLIN B1; FLAVONOID; GENISTEIN; PROTEIN KINASE;

BREAST CELL; CANCER CELL; CELL CYCLE; CELL CYCLE G2 PHASE; CELL LINE; CELL PROLIFERATION; CELL STRAIN MCF 7; CELL TRANSFORMATION; CHEMOPROPHYLAXIS; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFECT; DRUG SENSITIVITY; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; IC 50; LEGUME; PROTEIN PHOSPHORYLATION;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0036261054     PISSN: 13880209     EISSN: None     Source Type: Journal    
DOI: 10.1076/phbi.40.7.35.9176     Document Type: Conference Paper

References (43)

1. Effect of genistein on in vitro and in vivo models of cancer
2. Biochemical targets of the isoflavone genistein in tumor cell lines
3. Genistein modulates neuroblastoma cell proliferation and differentiation through induction of apoptosis and regulation of tyrosine kinase activity and N-myc expression
4. Effects of tyrosine kinase inhibitors on the proliferation of human breast cancer cell lines and proteins important in the ras signaling pathway
5. Induction of differentiation and DNA strand breakage in human HL-60 and K-562 leukemia cells by genistein
6. Inhibition of N-methyl-N-nitrosourea-induced mammary tumors in rats by the soybean isoflavones
7. Involvement of ERK2 and SAPK/JNK activation by TGFβ in the negative growth control of breast cancer cells
8. Cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2
9. Altered transforming growth factor β signaling in epithelial cells when Ras activation is blocked
10. Soy and experimental cancer animal studies
11. Growth inhibition with reversible cell cycle arrest of carcinoma cells by the flavone L86-8275
12. Mitosis in transition
13. Induction of human adenocarcinoma cell differentiation by the phytoestrogen genistein is independent of its antiestrogenic function
14. Negative regulation of Wee1 expression and cdc2 phosphorylation during p53-mediated growth arrest and apoptosis
15. The chemopreventative flavonoid apigenin induces G2/M arrest in keratinocytes
16. Induction of p21/WAF1 and G1 cell-cycle arrest by the chemopreventive agent apigenin
17. Potent inhibition of cdc2 kinase activity by the flavonoid L86-8275
18. Dietary estrogens act through estrogen receptor-mediated processes and show no antiestrogenicity in cultured breast cancer cells
19. Genistein arrests cell cycle progression in G2-M
20. Isoflavonoids and lignans in legumes: Nutritional and health aspects in humans
21. Human Wee1 kinase inhibits cell division by phosphorylating p34 cdc2 exclusively on Tyr15
22. Xenograft model of progressive human proliferative breast disease
23. Antiproliferative effect of genistein and adriamycin against estrogen-dependent and -independent human breast carcinoma cell lines
24. Animal cell cycles and their control
25. Growth-inhibitory effects of the natural phytoestrogen genistein in MCF-7 human breast cancer cells
26. Evaluation of the biochemical targets of genistein in tumor cells
27. Genistein inhibits both estrogen and growth factor-stimulated proliferation of human breast cancer cells
28. Genistein potently inhibits the growth of human primary breast epithelial cells: Correlation with a lack of genistein metabolism
29. The role of metabolism in mammary epithelial cell growth inhibition by the isoflavones genistein and biochanin A
30. Human cyclins A and B1 are differentially located in the cell and undergo cell-cycle dependent nuclear transport
31. WAF1/CIP1 induction, G2/M arrest, and apoptosis
32. A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells
33. Assessment of antineoplastic agents by MTT assay: Partial underestimation of antiproliferative properties
34. Cyclin activation of p34cdc2
35. Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10
36. Gradual phenotypic conversion associated with immortalization of cultured human mammary epithelial cells
37. Eating to beat breast cancer: Potential role for soy supplements
38. Effects of genistein on the growth and cell cycle progression of normal human lymphocytes and human leukemic MOLT-4 and HL-60 cells
39. Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity by genistein, a tyrosine kinase inhibitor
40. Molecular effects of genistein on estrogen-receptor mediated pathways
41. Inhibition of ultraviolet B (UVB)-induced c-fos and c-jun expression in vivo by a tyrosine kinase inhibitor genistein
42. Antioxidant and antipromotional effects of the soybean isoflavone genistein
43. The effect of quercetin on cell cycle progression and growth of human gastric cells