Activation of NADPH oxidase is required for macrophage-mediated oxidation of low-density lipoprotein

Metabolism: Clinical and Experimental

Volumn 45, Issue 9, 1996, Pages 1069-1079

  Aviram, Michael ^a   Rosenblat, Mira ^b   Etzioni, Amos ^b   Levy, Rachel ^b  

^a RAMBAM MEDICAL CENTER   (Israel)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXYICOSATETRAENOIC ACID; ARACHIDONATE 15 LIPOXYGENASE; COPPER SULFATE; CORIOLIC ACID; LOW DENSITY LIPOPROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; SUPEROXIDE DISMUTASE;

ADOLESCENT; ANIMAL CELL; ARTICLE; CASE REPORT; CHRONIC GRANULOMATOUS DISEASE; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LIPID OXIDATION; MACROPHAGE; MALE; MONOCYTE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SCHOOL CHILD;

EID: 0029783343     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(96)90005-0     Document Type: Article

References (54)

1. Witztum JL, Steinberg D: Role of oxidized low density lipoprotein in atherogenesis. J Clin Invest 88:1785-1792, 1991
2. Steinberg D, Parthasarathy S, Carew TE, et al: Beyond cholesterol: Modification of low density lipoprotein that increase its atherogenicity. N Engl J Med 320:915-924, 1989
3. Aviram M: Effect of lipoproteins and platelets on macrophage cholesterol metabolism, in Harris JR (ed): Blood Cell Biochemistry (vol 2). 1991, pp 179-208
4. Crawford DW, Blankenhorn DH: Arterial wall oxygenation, oxyradicals, and atherosclerosis. Atherosclerosis 89:97-108, 1991
5. Aviram M, Maor I, Keidar S, et al: Lesioned low density lipoprotein in atherosclerotic apolipoprotein E-deficient transgenic mice and in humans is oxidized and aggregated. Biochem Biophys Res Commun 216:501-513, 1995
6. Mitchinson MJ, Hothersall DC, Brooks PH, et al: The distribution of ceroid in human atherosclerosis. J Pathol 145:177-183, 1985
7. Leake DS, Rankin SM: The oxidative modification of low-density lipoproteins by macrophages. Biochem J 270:741-748, 1990
8. Aviram M: Modified forms of low density lipoprotein and atherosclerosis. Atherosclerosis 98:1-9, 1993
9. Parthasarathy S, Printz DJ, Boyd D, et al: Macrophage oxidation of low density lipoprotein generates a modified form recognized by the scavenger receptor. Arteriosclerosis 6:505-510, 1986
10. Smith C, Mitchinson MJ, Aruoma OI, et al: Stimulation of lipid peroxidation and hydroxyl-radical generation by the contents of human atherosclerotic lesions. Biochem J 286:901-905, 1992
11. Yamamoto S: "Enzymatic" lipid peroxidation: Reactions of mammalian lipoxygenases. Free Rad Biol Med 10:149-159, 1991
12. Hiramatsu K, Rosen H, Heinecke JW, et al: Superoxide initiates oxidation of low-density lipoprotein by human monocytes. Arteriosclerosis 7:55-60, 1987
13. Cathcart MK, McNally AK, Morel DW, et al: Superoxide anion participation in human monocyte-mediated oxidation of low density lipoprotein and conversion of low density lipoprotein to a cytotoxin. J Immunol 142:1963-1972, 1989
14. McNally AK, Chisolm GM, Morel DW, et al: Activated human monocytes oxidize low-density lipoprotein by a lipoxygenase-dependent pathway. J Immunol 145:254-259, 1990
15. Rankin SM, Parthasarathy S, Steinberg D: Evidence for a dominant role of lipoxygenase(s) in the oxidation of LDL by mouse peritoneal macrophages. J Lipid Res 32:449-456, 1991
16. Garner B, Dean RT, Jessup W: Human macrophage-mediated oxidation of low-density lipoprotein is delayed and independent of superoxide production. Biochem J 301:421-428, 1994
17. Heinecke JW, Kawamura M, Suzuki L, et al: Oxidation of low density lipoprotein by thiols: Superoxide-dependent and independent mechanisms. J Lipid Res 34:2051-2061, 1993
18. Wilkins GM, Segal AW, Leake DS: NADPH oxidase is not essential for low-density lipoprotein oxidation by human monocyte-derived macrophages. Biochem Biophys Res Commun 202:1300-1307, 1994
19. Aegal AW, Abo A: The biochemical basis of the NADPH oxidase of phagocytes. Trends Biochem Sci 18:43-47, 1993
20. 2+-depleted human neutrophils. Biochem J 290:173-178, 1993
21. Kono Y, Fridovich I: Superoxide radical inhibits catalase. J Biol Chem 257:5751-5754, 1982
22. Fukuzawa K, Gebicki JM: Oxidation of α-tocopherol in micelles and liposomes by the hydroxyl, perhydroxyl and superoxide free radicals. Arch Biochem Biophys 226:242-251, 1983
23. Sparrow CP, Olszewski J: Cellular oxidation of low density lipoprotein is caused by thiol production in media containing transition metal ions. J Lipid Res 34:1219-1228, 1993
24. Gebicki JM, Bielski BHJ: Comparison of the capacities of the perhydroxyl radical and the superoxide radicals to initiate chain oxidation of linoleic acid. J Am Chem Soc 103:7020-7028, 1981
25. Fujimori K, Nakajima H: Steady-state kinetics of autoxidation of NAD(P)H initiated by hydroperoxyl radical, the acid form of superoxide anion radical. Biochem Biophys Res Commun 176:846-851, 1991
26. Sparrow CP, Olszewski J: Cellular oxidative modification of low density lipoprotein does not require lipoxygenases. Proc Natl Acad Sci USA 89:128-131, 1992
27. Aviram M, Rosenblat M: Macrophage-mediated oxidation of extracellular low density lipoprotein requires an initial binding of the lipoprotein to its receptor. J Lipid Res 35:385-398, 1994
28. Curnutte JT: Chronic granulomatous disease: The solving of a clinical riddle at the molecular level. Clin Immunol 67:S2-S15, 1993
29. John I, Gallin MD, Harry L, et al: Update on chronic granulomatous diseases of childhood: Immunotherapy and potential for gene therapy. JAMA 263:1533-1537, 1990
30. Boyum A: Isolation of mononuclear cells and granulocytes from human blood. Scan J Clin Lab Invest (Suppl) 21:77-99, 1968
31. Aviram M: Low density lipoprotein modification by cholesterol oxidase induces enhanced uptake and cholesterol accumulation in cells. J Biol Chem 267:218-225, 1992
32. Aviram M: Plasma lipoprotein separation by discontinuous density gradient ultracentrifugation in hyperlipoproteinemic patients. Biochem Med 30:111-118, 1983
33. Buege JA, Aust SD: Microsomal lipid peroxidation. Methods Enzymol 52:302-310, 1978
34. El-Saadani M, Esterbauer H, El-Sayed M, et al: A spectrophotometric assay for lipid peroxides in serum lipoproteins using a commercially available reagent. J Lipid Res 30:627-630, 1989
35. Halliwell B, Gutteridge JMC: Role of free radicals and catalytic metal ions in human disease: An overview. Methods Enzymol 186:1-85, 1990
36. Derian CK, Lewis DF: Activation of 15-lipoxygenase by low density lipoprotein in vascular endothelial cells. Relationship to the oxidative modification of low density lipoprotein. Prostaglandins Leukot Essent Fatty Acids 45:49-57, 1992
37. Bligh EG, Dyer WJ: A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37:911-917, 1959
38. Jessup W, Darley-usmar V, O'leary V, et al: 5-Lipoxygenase is not essential in macrophage-mediated oxidation of low-density lipoprotein. Biochem J 278:163-169, 1991
39. Dana R, Malech LH, Levy R: The requirement of phospholipase A2 in the activation of the assembled NADPH oxidase in human neutrophils. Biochem J 297:217-223, 1994
40. Levy R, Dana R, Leto TL, et al: The requirement of p-47 phosphorylation for activation of NADPH oxidase by opsonized zymosan in human neutrophils. Biochim Biophys Acta 1220:253-260, 1994
41. Heinecke JW, Baker L, Rosen H, et al: Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cells. J Clin Invest 77:757-761, 1986
42. Esterbauer H, Striegl G, Puhl H, et al: Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Rad Res Commun 6:67-75, 1989
43. Schewe T, Kuhn H: Do 15-lipoxygenases have a common biological role? Trends Biol Sci 16:369-373, 1991
44. Yla-Herttuala S, Rosenfeld ME, Parthasarathy S, et al: Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions. Proc Natl Acad Sci USA 87:6959-6963, 1990
45. Jessup W, Simpson JA, Dean RT: Does superoxide radical have a role in macrophage-mediated oxidative modification of LDL? Atherosclerosis 99:107-120, 1993
46. Bedwell S, Dean RT, Jessup W: The action of defined oxygen-centered free radicals on human low-density lipoprotein. Biochem J 262:707-712, 1989
47. Oleary VJ, Darley-Usmar VM, Russell LJ, et al: Pro-oxidant effects of lipoxygenase-derived peroxides on the copper-initiated oxidation of low density lipoprotein. Biochem J 282:631-634, 1992
48. Aviram M, Lund-Katz S, Phillips M, et al: The influence of the triglyceride content of low density lipoprotein on the interaction of apolipoprotein B-100 with cells. J Biol Chem 263:16842-16848, 1988
49. Suits AG, Chait A, Aviram M, et al: Phagocytosis of aggregated lipoprotein by macrophages: Low density lipoprotein receptor dependent foam cell formation. Proc Natl Acad Sci USA 86:2713-2717, 1989
50. Heinecke JW, Suits AG, Aviram M, et al: Phagocytosis of lipase-aggregated low density lipoprotein promotes macrophage foam cell formation. Sequential morphological and biochemical events. Arterioscler Thromb 11:1643-1651, 1991
51. Aviram M, Maor I: Phospholipase A2 modified LDL is taken up at enhanced rate by macrophages. Biochem Biophys Res Commun 185:465-472, 1992
52. Aviram M, Maor I: Phospholipase D modified low density lipoprotein is taken up by macrophages at increased rate: A possible role for phosphatidic acid. J Clin Invest 91:1942-1952, 1993
53. Aviram M, Bierman EL, Chait A: Modification of low density lipoprotein by lipoprotein lipase or hepatic lipase induces enhanced uptake and cholesterol accumulation in cells. J Biol Chem 263:15416-15422, 1988
54. Bauldry SA, Elasey KL, Bass DA: Activation of NADPH oxidase and phospholipase D in permeabilized human neutrophils. J Biol Chem 263:25141-25152, 1992