Molecular requirements for inhibition of cytochrome P450 activities by roquefortine

Chemical Research in Toxicology

Volumn 14, Issue 9, 2001, Pages 1259-1265

  Aninat, C ^a   Hayashi, Y ^b   Andre F ^c   Delaforge, M ^a,c  

^a Institut National de la Recherche Agronomique   (France)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^c CEA SACLAY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BENZPHETAMINE; BROMOCRIPTINE; CYCLOPEPTIDE; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DEXAMETHASONE; HEME; IMIDAZOLE; PHENOBARBITAL; PIPERAZINEDIONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; ROQUEFORTINE; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BACTERIAL GROWTH; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; LIVER MICROSOME; METABOLITE; MOLECULAR INTERACTION; NEUROTOXICITY; NONHUMAN; PENICILLIUM; ULTRAVIOLET RADIATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; ERGOLINES; HEME; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; INDOLES; LIVER; MALE; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; SPECTRUM ANALYSIS; TESTOSTERONE;

EID: 0034803268     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx015512l     Document Type: Article

References (32)

1. Toxins of Amanita phalloides
2. In vivo pharmacological effects of cyclosporin and some analogues
3. Multiple receptors for dopamine
4. Antimicrobial action of roquefortine
5. Synthesis and biological activities of phenylahistin derivatives
6. Bioactive cyclic dipeptides
7. Metabolism of cyclosporin A. IV. Purification and identification of the rifampicin-inducible human liver cytochrome P-450 (cyclosporin A oxidase) as a product of P450IIIA gene subfamily
8. High affinity of ergopeptides for cytochromes P450 3A. Importance of their peptide moiety for P450 recognition and hydroxylation of bromocriptine
9. Metabolism of tentoxin by hepatic cytochrome P-450 3A isozymes
10. Recognition and oxidative metabolism of cyclodipeptides by hepatic cytochrome P450
11. Interaction of amino acids and small peptides with rat and human cytochromes P450. Particular involvement of isozyme 3A
12. Elucidation of distinct ligand binding sites for cytochrome P450 3A4
13. Isolation of festuclavine and three new indole alkaloids, roquefortine A, B and C from the cultures of Penicillium roqueforti (Production of Alkaloids and Related Substances by Fungi Part XII)
14. Toxin production by 50 strains of Penicillium used in the cheese industry
15. Synthesis and metabolism of roquefortine in Penicillium species
16. Acute toxicity studies on roquefortine and PR toxin, metabolites of Penicillium roqueforti, in the mouse
17. Isolation of roquefortine C from feed grain
18. Molecular identification of species from the Penicillium roqueforti group associated with spoiled animal feed
19. Total synthesis of anti-microtubule diketopiperazine derivatives: Phenylahistin and aurantiamine
20. Cytochrome P-450 monooxygenase activities in human and rat liver microsomes
21. Optimization of yeast-expressed human liver cytochrome P450 3A4 catalytic activities by coexpressing NADPH-cytochrome P450 reductase and cytochrome b5
22. Protein measurement with the Folin-Phenol reagents
23. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature
24. Substrate interaction with cytochrome P-450
25. Particular ability of cytochromes P450 3A to form inhibitory P450-iron-metabolite complexes upon metabolic oxidation of aminodrugs
26. Direct fluorometric methods for measuring mixed function oxidase activity
27. Inhibition of cytochrome P450 enzymes
28. Specificity in the activation and inhibition by flavonoids of benzo[a]pyrene hydroxylation by cytochrome P-450 isozymes from rabbit liver microsomes
29. Studies on the mechanism of activation of microsomal benzo[a]pyrene hydroxylation by flavonoids
30. Allosteric regulation of the 16 alpha-hydroxylation of progesterone as catalyzed by rabbit microsomal cytochrome P-450 3b
31. Positive effectors of the binding of an active site-directed amino steroid to rabbit cytochrome P-450 3c
32. Mechanism of cytochrome P450 activation by caffeine and 7,8-benzoflavone in rat liver microsomes