Identification of a quorum-sensing signal molecule in the facultative intracellular pathogen Brucella melitensis

Infection and Immunity

Volumn 70, Issue 6, 2002, Pages 3004-3011

  Taminiau, Bernard ^a   Daykin, Mavis ^a   Swift, Simon ^a   Boschiroli, Maria Laura ^a   Tibor, Anne ^a   Lestrate, Pascal ^a   De Bolle, Xavier ^a   O'Callaghan, David ^a   Williams, Paul ^a   Letesson, Jean Jacques ^a  

^a UNIVERSITY OF NAMUR   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; HOMOSERINE; LACTONE DERIVATIVE; N ACYLHOMOSERINE LACTONE; N DODECANOYLHOMOSERINE LACTONE; PROTEIN LASR; UNCLASSIFIED DRUG;

ABORTION; ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL VIRULENCE; BRUCELLA MELITENSIS; BRUCELLOSIS; CONTROLLED STUDY; ESCHERICHIA COLI; GOAT DISEASE; NONHUMAN; OPERON; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA;

4-BUTYROLACTONE; BACTERIAL PROTEINS; BRUCELLA MELITENSIS; CULTURE MEDIA; INTRACELLULAR FLUID; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; VIRULENCE FACTORS;

EID: 0036259884     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.6.3004-3011.2002     Document Type: Article

References (71)

1. Transposon-derived Brucella abortus rough mutants are attenuated and exhibit reduced intracellular survival
2. A hierarchical quorum-sensing system in Yersinia pseudotuberculosis is involved in the regulation of motility and clumping
3. The Brucella suis virB operon is induced intracellularly in macrophages
4. Biochemistry of type IV secretion
5. Autoregulation of carbapenem biosynthesis in Erwinia carotovora by analogues of N-(3-oxohexanoyl)-L-homoserine lactone
6. Modulation of phagosome biogenesis by Legionella pneumophila creates an organelle permissive for intracellular growth
7. In vivo and ex vivo regulation of bacterial virulence gene expression
8. Molecular characterization and regulation of the rhizosphere-expressed genes rhiABCR that can influence nodulation by Rhizobium leguminosarum biovar viciae
9. Identification of a global repressor gene, rsmA, of Erwinia carotovora subsp. carotovora that controls extracellular enzymes, N-(3-oxohexanoyl)-L-homoserine lactone, and pathogenicity in soft-rotting Erwinia spp.
10. The involvement of cell-to-cell signals in the development of a bacterial biofilm
11. Identification of Brucella spp. genes involved in intracellular trafficking
12. Penetration and intracellular growth of Brucella abortus in nonphagocytic cells in vitro
13. Bacterial life: Neither lonely nor boring
14. Identification of Brucella suis genes affecting intracellular survival in an in vitro human macrophage infection model by signature-tagged transposon mutagenesis
15. Quorum sensing in bacteria: The LuxR-LuxI family of cell density-responsive transcriptional regulators
16. Identification of the perosamine synthetase gene of Brucella melitensis 16M and involvement of lipopolysaccharide O side chain in Brucella survival in mice and in macrophages
17. Quorum-sensing cross talk: Isolation and chemical characterization of cyclic dipeptides from Pseudomonas aeruginosa and other gram-negative bacteria
18. Identification of genes required for chronic persistence of Brucella abortus in mice
19. Molecular cloning and characterization of cgs, the Brucella abortus cyclic beta(1-2) glucan synthetase gene: Genetic complementation of Rhizobium meliloti ndvB and Agrobacterium tumefaciens chvB mutants
20. In vitro biosynthesis of the Pseudomonas aeruginosa quorum-sensing signal molecule N-butanoyl-L-homoserine lactone
21. The lux autoinducer regulates the production of exoenzyme virulence determinants in Erwinia carotovora and Pseudomonas aeruginosa
22. Diffusion of autoinducer is involved in regulation of the Vibrio fischeti luminescence system
23. Participation of the molecular chaperone DnaK in intracellular growth of Brucella suis within U937-derived phagocytes
24. Response of Brucella suis 1330 and B. canis RM6/66 to growth at acid pH and induction of an adaptive acid tolerance response
25. A hierarchical quorum-sensing cascade in Pseudomonas aeruginosa links the transcriptional activators LasR and RhIR (VsmR) to expression of the stationary-phase sigma factor RpoS
26. The Pseudomonas aeruginosa quorumsensing signal molecule, N-(3-oxododecanoyl)-L-homoserine lactone, inhibits porcine arterial smooth muscle contraction
27. Identification and characterization of in vivo attenuated mutants of Brucella melitensis
28. Quorum sensing in Burkholderia cepacia: Identification of the LuxRI homologs CepRI
29. The regulatory locus cinRI in Rhizobium leguminosarum controls a network of quorum-sensing loci
30. Investigation of quorum sensing in Aeromonas hydrophila biofilms formed on stainless steel
31. Quorum sensing and Chromobacterium violaceum: Exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones
32. Genetic characterization of a Tn5-disrupted glycosyltransferase gene homolog in Brucella abortus and its effect on lipopolysaccharide composition and virulence
33. Enzymatic synthesis of a quorum-sensing autoinducer through use of defined substrates
34. A homologue of the Agrobacterium tumefaciens VirB and Borderella pertussis Ptl type IV secretion systems is essential for intracellular survival of Brucella suis
35. Acyl homoserine-lactone quorum-sensing signal generation
36. Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication
37. Pseudomonas aeruginosa cell-to-cell signaling is required for virulence in a model of acute pulmonary infection
38. Active efflux and diffusion are involved in transport of Pseudomonas aeruginosa cell-to-cell signals
39. Hierarchical gene regulatory systems arising from fortuitous gene associations: Controlling quorum sensing by the opine regulon in Agrobacterium
40. A small diffusible signal molecule is responsible for the global control of virulence and exoenzyme production in the plant pathogen Erwinia carotovora
41. Brucella abortus transits through the autophagic pathway and replicates in the endoplasmic reticulum of nonprofessional phagocytes
42. A quorumsensing system in the free-living photosynthetic bacterium Rhodobacter sphaeroides
43. The Brucella abortus host factor I (HF-I) protein contributes to stress resistance during stationary phase and is a major determinant of virulence in mice
44. Analysis of quorum-sensing-dependent control of rhizosphere-expressed (rhi) genes in Rhizobium leguminosarum bv. viciae
45. Legionella pneumophila DotA protein is required for early phagosome trafficking decisions that occur within minutes of bacterial uptake
46. Contribution of quorum sensing to the virulence of Pseudomonas aeruginosa in burn wound infections
47. Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone inhibits expression of P2Y receptors in cystic fibrosis tracheal gland cells
48. Generation of cell-to-cell signals in quorum sensing: Acyl homoserine lactone synthase activity of a purified Vibrio fischeri LuxI protein
49. Positive autoregulation of the Vibrio fischeri luxR gene. LuxR and autoinducer activate cAMP-catabolite gene activator protein complex-independent and -dependent luxR transcription
50. Detecting and characterizing N-acyl-homoserine lactone signal molecules by thin-layer chromatography
51. A homologue of an operon required for DNA transfer in Agrobacterium is required in Brucella abortus for virulence and intracellular multiplication
52. A broad host range mobilization system for in vivo genetic engineering: Transposon mutagenesis in gram negative bacteria
53. Pathogenesis of Brucella
54. A two-component regulatory system playing a critical role in plant pathogens and endosymbionts is present in Brucella abortus and controls cell invasion and virulence
55. Quorum sensing in Vibrio fischeri: Essential elements for activation of the luminescence genes
56. Quorum sensing in Aeromonas hydrophila and Aeromonas salmonicida: Identification of the LuxRI homologs AhyRI and AsaRI and their cognate N-acylhomoserine lactone signal molecules
57. Quorum sensing-dependent regulation and blockade of exoprotease production in Aeromonas hydrophila
58. The inner workings of a quorum sensing signal generator
59. N-acylhomoserine lactones and quorum sensing in Proteobacteria
60. The Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone has immunomodulatory activity
61. In vivo evidence that S-adenosylmethionine and fatty acid synthesis intermediates are the substrates for the LuxI family of autoinducer synthases
62. Conjugative transfer and in vitro/in vivo stability of the broad-host-range IncP R751 plasmid in Brucella spp.
63. Vibrio fischeri lux genes play an important role in colonization and development of the host light organ
64. A negative regulator mediates quorum-sensing control of exopolysaccharide production in Pantoea stewartii subsp. stewartii
65. N-acyl homoserine lactone binding to the CarR receptor determines quorum-sensing specificity in Erwinia
66. Quorum sensing and the population-dependent control of virulence
67. Multiple N-acyl-L-homoserine lactone signal molecules regulate production of virulence determinants and secondary metabolites in Pseudomonas aeruginosa
68. Construction and analysis of luxCDABE-based plasmid sensors for investigating N-acyl homoserine lactone-mediated quorum sensing
69. + T cells by Brucella infection or immunization with antigenic extracts
70. Autoinducer binding by the quorum-sensing regulator TraR increases affinity for target promoters in vitro and decreases TraR turnover rates in whole cells