Dissociation of protein kinase-mediated regulation of metabotropic glutamate receptor 7 (mGluR7) interactions with calmodulin and regulation of mGluR7 function

Molecular Pharmacology

Volumn 61, Issue 6, 2002, Pages 1303-1312

  Sorensen, Scott D ^a,b   Macek, Thomas A ^a,b,c   Cai, Zhaohui ^a,b,d   Saugstad, Julie A ^a,b,e   Jeffrey Conn, P ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c PFIZER INC   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e LEGACY RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALMODULIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE; GLUTAMIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; METABOTROPIC RECEPTOR; PRESYNAPTIC RECEPTOR; PROTEIN KINASE; PROTEIN KINASE C; SERINE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DISSOCIATION; EMBRYO; HUMAN; HUMAN CELL; MUTATION; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; SECOND MESSENGER; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION;

AMINO ACID SUBSTITUTION; ANIMALS; CALMODULIN; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC GMP-DEPENDENT PROTEIN KINASES; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; HUMANS; PHOSPHORYLATION; POINT MUTATION; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN KINASE C; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; SECOND MESSENGER SYSTEMS; SERINE; TRANSFECTION;

EID: 0036259096     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.61.6.1303     Document Type: Article

References (25)

1. PKC phosphorylation of a conserved serine residue in the C-terminus of group III metabotropic glutamate receptors inhibits calmodulin binding
2. Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site
3. Immunocytochemical localization of group III metabotropic glutamate receptors in the hippocampus with subtype-specific antibodies
4. Cyclic AMP-dependent protein kinase phosphorylates group III metabotropic glutamate receptors and inhibits their function as presynaptic receptors
5. Pharmacology and function of metabotropic glutamate receptors
6. PICK1 interacts with and regulates PKC phosphorylation of mGluR7
7. 7 receptors by proteins that interact with the intracellular C-terminus
8. Mapping of calmodulin and Gβγbinding domains within the C-terminal region of the metabotropic glutamate receptor 7A
9. Interaction of the C-terminal tail region of the metabotropic glutamate receptor 7 with the protein kinase C substrate PICK1
10. Protein kinase C disrupts cannabinoid actions by phosphorylation of the CB1 cannabinoid receptor
11. Multiple presynaptic metabotropic glutamate receptors modulate excitatory and inhibitory synaptic transmission in hippocampal area CA1
12. Role of protein kinase C phosphorylation in rapid desensitization of metabotropic glutamate receptor 5
13. Heptahelical receptor signaling: Beyond the G protein paradigm
14. 2-Amino-4-phosphonobutyrate selectively blocks mossy fiber-CA3 responses in guinea pig but not rat hippocampus
15. 3 adenosine receptor activation inhibit presynaptic metabotropic glutamate receptor (mGluR) function and uncouple mGluRs from GTP-binding proteins
16. Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion
17. Phosphorylation and calmodulin binding of the metabotropic glutamate receptor subtype 5 (mGluR5) are antagonistic in vitro
18. A relationship between protein kinase C phosphorylation and calmodulin binding to the metabotropic glutamate receptor subtype 7
19. Calmodulin dependence of presynaptic metabotropic glutamate receptor signaling
20. Selective blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type 7 involves a phospholipase C pathway in neurons
21. Cloning and expression of a new member of the L-2-amino-4-phosphonobutyric acid-sensitive class of metabotropic glutamate receptors
22. Metabotropic glutamate receptors activate G-protein-coupled inwardly rectifying potassium channels in Xenopus oocytes
23. cAMP-dependent protein kinase inhibits mGluR2 coupling to G-proteins by direct receptor phosphorylation
24. Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone
25. Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus