Mitochondrial dysfunction due to oxidative mitochondrial DNA damage is reduced through cooperative actions of diverse proteins

Molecular and Cellular Biology

Volumn 22, Issue 12, 2002, Pages 4086-4093

  O'Rourke, Thomas W ^a   Doudican, Nicole A ^a   Mackereth, Melinda D ^a   Doetsch, Paul W ^a   Shadel, Gerald S ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; GENE PRODUCT; MITOCHONDRIAL DNA; PROTEIN ABF2; PROTEIN CCE1; PROTEIN NUC1; PROTEIN PIF1; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA RECOMBINATION; ELECTRON TRANSPORT; ENZYME ACTIVITY; EXCISION REPAIR; GENE INACTIVATION; MITOCHONDRIAL GENETICS; MITOCHONDRIAL RESPIRATION; MUTAGENESIS; NONHUMAN; OXIDATION; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; STRAIN DIFFERENCE;

DNA DAMAGE; DNA HELICASES; DNA REPAIR; DNA, MITOCHONDRIAL; DNA-BINDING PROTEINS; ENDODEOXYRIBONUCLEASES; ENDONUCLEASES; FUNGAL PROTEINS; HOLLIDAY JUNCTION RESOLVASES; MITOCHONDRIA; MUTAGENESIS; MUTATION; N-GLYCOSYL HYDROLASES; OXIDATIVE STRESS; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTORS; YEASTS;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0036258184     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.12.4086-4093.2002     Document Type: Article

References (57)

1. The Saccharomyces cerevisiae homologues of endonuclease III from Escherichia coli, Ntg1 and Ntg2, are both required for efficient repair of spontaneous and induced oxidative DNA damage in yeast
2. The Pif1p subfamily of helicases: Region-specific DNA helicases?
3. Enzymology of mitochondrial base excision repair
4. DNA postreplication repair and mutagenesis in Saccharomyces cerevisiae
5. Purification and characterization of MSH1, a yeast mitochondrial protein that binds to DNA mismatches
6. The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria
7. Mitochondrial DNA r0epair pathways
8. A single nucleotide substitution at the rib2 locus of the yeast mitochondrial gene for 21S rRNA confers resistance to erythromycin and cold-sensitive ribosome assembly
9. Purification and properties of the major nuclease from mitochondria of Saccharomyces cerevisiae
10. A close relative of the nuclear, chromosomal high-mobility group protein HMG1 in yeast mitochondria
11. DNA binding properties of an HMG1-related protein from yeast mitochondria
12. Yeast base excision repair: Interconnections and networks
13. Nucleosomal histone protein protects DNA from iron-mediated damage
14. Does human mtDNA recombine?
15. Localization of a cruciform cutting endonuclease to yeast mitochondria
16. DNA wrapping and bending by a mitochondrial high mobility group-like transcriptional activator protein
17. pif mutation blocks recombination between mitochondrial rho+ and rho- genomes having tandemly arrayed repeat units in Saccharomyces cerevisiae
18. Cloning and sequencing of the PIF gene involved in repair and recombination of yeast mitochondrial DNA
19. Procedure for detecting outlying observations in samples
20. Synthetic enhancement in gene interaction: A genetic tool come of age
21. Substrate specificity of a mammalian DNA repair endonuclease that recognizes oxidative base damage
22. The Saccharomyces Pif1p DNA helicase and the highly related Rrm3p have opposite effects on replication fork progression in ribosomal DNA
23. Identification and characterization of yeast mutants and the gene for a cruciform cutting endonuclease
24. PIF1: A DNA helicase in yeast mitochondria
25. Molecular genetic aspects of human mitochondrial disorders
26. Base excision repair of mitochondrial DNA damage in mammalian cells
27. Quality control by DNA repair
28. A role for MHR1, a gene required for mitochondrial genetic recombination, in the repair of damage spontaneously introduced in yeast mtDNA
29. A role for recombination junctions in the segregation of mitochondrial DNA in yeast
30. The high mobility group protein Abf2p influences the level of yeast mitochondrial DNA recombination intermediates in vivo
31. Analysis of mitochondrial DNA nucleoids in wild-type and a mutant strain of Saccharomyces cerevisiae that lacks the mitochondrial HMG box protein Abf2p
32. Base excision repair in a network of defense and tolerance
33. Repair of chromosomal abasic sites in vivo involves at least three different repair pathways
34. A human mitochondrial transcriptional activator can functionally replace a yeast mitochondrial HMG-box protein both in vivo and in vitro
35. A rapid and simple method for the preparation of yeast mitochondrial DNA
36. Normal oxidative damage to mitochondrial and nuclear DNA is extensive
37. Nam1p, a protein involved in RNA processing and translation, is coupled to transcription through an interaction with yeast mitochondrial RNA polymerase
38. Repair of DNA damage in mitochondria
39. The Saccharomyces PIF1 DNA helicase inhibits telomere elongation and de novo telomere formation
40. A mutation in a mitochondrial ABC transporter results in mitochondrial dysfunction through oxidative damage of mitochondrial DNA
41. Substrate specificities of the ntg1 and ntg2 proteins of Saccharomyces cerevisiae for oxidized DNA bases are not identical
42. Yeast as a model for human mtDNA replication
43. Mitochondrial DNA maintenance in vertebrates
44. Getting started with yeast
45. In vitro mutagenesis and plasmid shuffling: From cloned gene to mutant yeast
46. Inactivation of Saccharomyces cerevisiae OGG1 DNA repair gene leads to an increased frequency of mitochondrial mutants
47. Overlapping specificities of base excision repair, nucleotide excision repair, recombination, and translesion synthesis pathways for DNA base damage in Saccharomyces cerevisiae
48. Mitochondrial targeting of human DNA glycosylases for repair of oxidative DNA damage
49. Mammalian mitochondria possess homologous DNA recombination activity
50. Pir1p mediates translocation of the yeast Apn1p endonuclease into the mitochondria to maintain genomic stability
51. Mitochondrial diseases in man and mouse
52. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
53. Saccharomyces cerevisiae possesses two functional homologues of Escherichia coli endonuclease III
54. Saccharomyces cerevisiae Ntg1p and Ntg2p: Broad specificity N-glycosylases for the repair of oxidative DNA damage in the nucleus and mitochondria
55. Enediyne-mediated DNA damage in nuclei is modulated at the level of the nucleosome
56. Analysis of the role of the NUC1 endo/exonuclease in yeast mitochondrial DNA recombination
57. Functions of the high mobility group protein, Abf2p, in mitochondrial DNA segregation, recombination and copy number in Saccharomyces cerevisiae