Rejuvenating views of the ageing process

Nature Reviews Genetics

Volumn 3, Issue 2, 2002, Pages 149-153

  Helfand, Stephen L ^a   Inouye, Sharon K ^b  

^a UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; CLINICAL RESEARCH; DEMOGRAPHY; HUMAN; LIFESPAN; MOLECULAR GENETICS; NONHUMAN; PRIORITY JOURNAL; RESEARCH; REVIEW;

AGING; ANIMALS; GENE EXPRESSION; HOMEOSTASIS; HUMANS; MUTATION; POPULATION DYNAMICS;

EID: 0036254145     PISSN: 14710056     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrg726     Document Type: Review

References (69)

1. Successful aging
2. Finch New models for new perspectives in the biology of senescence
3. Variations in senescence and longevity include the possibility of negligible senescence
4. Aging and development in social insects with emphasis on the honey bee, Apis mellifera L
5. Ageing in reptiles
6. Ageing in fishes
7. Age determination and validation studies of marine fishes: Do deep-dwellers live longer?
8. Does bristlecone pine senesce?
9. Escaping senescence: Demographic data from the three-toed box turtle (Terrapene carolina triunguis)
10. Maximum ages of groundfishes in waters off Alaska and British Columbia and considerations of age determination
11. Human aging: Usual and successful
12. A predictive model for delirium in hospitalized elderly medical patients based on admission characteristics
13. Decline in synthesis of elongation factor one (EF-1) precedes the decreased synthesis of total protein in aging Drosophila melanogaster
14. Specific disappearance of translatable messenger RNA for elongation factor one in aging Drosophila melanogaster
15. Protein synthesis elongation factor EF-1 α expression and longevity in Drosophila melanogaster
16. Temporal patterns of gene expression in the antenna of the adult Drosophila melanogaster
17. Regulation of gene expression is linked to life span in adult Drosophila
18. Muscle-specific expression of Drosophila hsp70 in response to aging and oxidative stress
19. Timing of expression of a gene in the adult Drosophila is regulated by mechanisms independent of temperature and metabolic rate
20. Spatial and temporal pattern of expression of the wingless and engrailed genes in the adult antenna is regulated by age-dependent mechanisms
21. Aging-specific expression of Drosophila hsp22
22. Regulation of gene expression during aging
23. Differential regulation of the messenger RNA for three major senescence marker proteins in male rat liver
24. Androgen receptor messenger ribonucleic acid (mRNA) in the rat liver: Changes in mRNA levels during maturation, aging and calorie restriction
25. A novel regulatory element associated with age-dependent expression of the rat androgen receptor gene
26. Age-dependent increase of heme oxygenase-1 gene expression in the liver mediated by NFκB
27. Gene expression profile of aging and its retardation by caloric restriction
28. Gene-expression profile of the ageing brain in mice
29. The effects of aging on gene expression in the hypothalamus and cortex of mice
30. Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys
31. Regulation of gene expression is preserved in aging Drosophila melanogaster
32. Shared risk factors for falls, incontinence, and functional dependence. Unifying the approach to geriatric syndromes
33. Precipitating factors for delirium in hospitalized elderly persons. Predictive model and interrelationship with baseline vulnerability
34. How should clinical care of the aged differ?
35. Extension of Drosophila lifespan by overexpression of human SOD 1 in motorneurons
36. Dwarf mice and the ageing process
37. Extended life-span and stress resistance in the Drosophila mutant methuselah
38. Delayed aging in Ames dwarf mice. Relationships to endocrine function and body size
39. Assessment of growth parameters and life span of GHR/BP gene-disrupted mice
40. Genetic pathways that regulate ageing in model organisms
41. Crossroads of aging in the nematode Caenorhabditis elegans
42. Extended life-span conferred by cotransporter gene mutations in Drosophila
43. Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
44. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
45. The genetics of aging
46. Coordination of metabolic activity and stress resistance in yeast longevity
47. Metabolic control and ageing
48. On the nature of the function expressive of the law of human mortality, and a new mode of determining the value of life contingencies
49. Slowing of mortality rates at older ages in large medfly cohorts
50. Demography of genotypes: Failure of the limited life-span paradigm in Drosophila melanogaster
51. Mortality dynamics of density in the Mediterranean fruit fly
52. Biodemographic trajectories of longevity
53. A new biodemographic model to explain the trajectory of mortality
54. Supercentenarians: Slower ageing individuals or senile elderly?
55. Ageing: Levelling of the grim reaper
56. The evolving concept of the healthy worker survivor effect
57. Evidence of a healthy estrogen user survivor effect
58. Compositional interpretations of medfly mortality
59. A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4
60. Maximum ages of groundfishes in waters off Alaska and British Columbia and considerations of age determination
61. Escaping senescence: Demographic data from the three-toed box turtle (Terrapene carolina triunguis)
62. Regulation of gene expression during aging
63. The oldest human