Genetic evidence of a role for ATM in functional interaction between human T-cell leukemia virus type 1 Tax and p53

Journal of Virology

Volumn 75, Issue 1, 2001, Pages 396-407

  Van, P L ^a   Yim, K W ^a   Jin, D Y ^a   Dapolito, G ^a   Kurimasa, A ^a   Jeang, K T ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE; PROTEIN P53; TAX PROTEIN;

ANIMAL CELL; ARTICLE; CELL ADHESION; EPITHELIUM CELL; GENE REPRESSION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE ACTIVATION;

CELL CYCLE PROTEINS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; GENE PRODUCTS, TAX; HELA CELLS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMAN T-LYMPHOTROPIC VIRUS 2; HUMANS; MUTATION; NF-KAPPA B; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; REPRESSOR PROTEINS; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 0034749346     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.1.396-407.2001     Document Type: Article

References (103)

1. The p53 network
2. Aberrant expression and function of p53 in T-cells immortalized by HTLV-I Tax1
3. Human T-cell leukemia virus types I and II exhibit different DNase I protection patterns
4. Enhanced phosphorylation of p53 serine 18 following DNA damage in DNA-dependent protein kinase catalytic subunit-deficient cells
5. HTLV-1 tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration
6. Regulation of p53 function and stability by phosphorylation
7. HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene
8. Human T-cell leukemia virus type I Tax associates with and is negatively regulated by the NF-κB2 p100 gene product: Implications for viral latency
9. Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300
10. DNA damage induced p53 stabilization: No indication for an involvement of p53 phosphorylation
11. Identifcation of p40x-responsive regulatory sequences within the human T-cell leukemia virus type I long terminal repeat
12. DNA-dependent protein kinase-independent activation of p53 in response to DNA damage
13. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
14. Functional and biochemical interaction of the HTLV-I Tax1 transactivator with TBP
15. Hepatitis B virus X protein and p53 tumor suppressor interaction in the modulation of apoptosis
16. Molecular mechanism of human T-cell leukemia/lymphotropic virus type 1 infection
17. Mechanisms of Tax regulation of human T cell leukemia virus type 1 gene expression
18. Interaction of HTLV-1 Tax1 with p67SRF causes the aberrant induction of cellular immediate early genes through CArG boxes
19. c-fos promoter transactivation by the tax1 protein of human T-cell leukemia virus type I
20. The first human retrovirus
21. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis
22. HTLV-I tax gene product activates transcription via pre-existing cellular factors and cAMP responsive element
23. Anchoring of CREB binding protein to the human T-cell leukemia virus type 1 promoter: A molecular mechanism of Tax transactivation
24. p53 in growth control and neoplasia
25. Role of human T-cell leukemia virus type I X region proteins in immortalization of primary human lymphocytes in culture
26. Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a herpesvirus saimiri vector
27. Molecular basis for heterogeneity of the human p53 protein
28. p300 and p300/cAMP-responsive element-binding protein associated factor interact with human T-cell lymphotropic virus type-1 Tax in a multi-histone acetyltransferase/activator-enhancer complex
29. An exposed KID-like domain in human T-cell lymphotrope virus type 1 Tax is responsible for the recruitment of coactivator CBP/p300
30. Antibodies to adult T-cell leukemia-virus-associated antigen (ATLA) in sera from patients with ATL and controls in Japan: A nation-wide sero-epidemiologic study
31. Transcriptional activator Tax of HTLV-1 binds to the NF-kappa B precursor p105
32. Molecular interactions between HTLV-I Tax protein and the NF-kappa B/kappa B transcription complex
33. Sequence variation of functional HTLV-II Tax alleles among isolates from endemic population: Lack of evidence of oncogenic determinant in Tax
34. Characterization of cellular factors that interact with the human T-cell leukemia virus type I p40x-responsive 21-base-pair sequence
35. HTLV-I trans-activator protein, tax, is a trans-repressor of the human beta-polymerase gene
36. Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular transformation
37. Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1
38. HTLV-1 Tax protein sensitizes cells to apoptotic cell death induced by DNA damaging agents
39. Cooperative phosphorylation at multiple sites is required to activate p53 in response to UV radiation
40. The coactivator CBP stimulates human T-cell lymphotrophic virus type I Tax transactivation in vitro
41. Oncogenic forms of p53 inhibit p53-regulated gene expression
42. ATM associates with and phosphorylates p53: Mapping the region of interaction
43. Taxing the cellular capacity for repair: Human T-cell leukemia virus type 1, DNA damage, and adult T-cell leukemia
44. Identification of a human T-cell leukemia virus type I tax peptide in contact with DNA
45. p53: Puzzle and paradigm
46. Catalytic subunit of DNA-dependent protein kinuse: Impact on lymphocyte development and tumorigenesis
47. Control of cAMP-regulated enhancers by the vital transactivator Tax through CREB and the co-activator CBP
48. Cancer, p53, guardian of the genome
49. Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large suppressor protein
50. The tax protein-DNA interaction is essential for HTLV-I transactivation in vitro
51. p53, the cellular gatekeeper for growth and division
52. The 1993 Walter Hubert Lecture: The role of the p53 tumour-suppressor gene in tumorigenesis
53. Activation of human T-cell leukemia virus type I tax gene expression in chronically infected T cells
54. Induction of micronuclei by HTLV-I Tax: A cellular assay for function
55. Large granular lymphocytosis in a patient infected with HTLV
56. Multiple control levels of cell proliferation by human T-cell leukemia virus type 1 Tax protein
57. Trans-activator Tax of human T-cell leukemia virus type 1 enhances mutation frequency of the cellular genome
58. Two distinct mechanisms alter p53 in breast cancer: Mutation and nuclear exclusion
59. Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors
60. Human T-cell lymphotropic/leukemia virus type I Tax abrogates p53-induced cell cycle arrest and apoptosis through its CREB/ATF functional domain
61. HTLV-I Tax enhances NK-kappa B2 expression and binds to the products p52 and p100, but does not suppress the inhibitory function of p100
62. Modeling the risk of adult T-cell leukemia/lymphoma in persons infected with human T-lymphotropic virus type I
63. Requirement of ATM in phosphorylation of the human p53 protein at serine 15 following DNA double-strand breaks
64. The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice
65. HTLV-I Tax and cell cycle progression
66. HTLV-I Tax transrepresses the human c-Myb promoter independently of its interaction with CBP or p300
67. Binding of host-cell factors to DNA sequences in the long terminal repeat of human T-cell leukemia virus type I: Implications for viral gene expression
68. HTLV-I associated myelopathy, a new clinical entity
69. The ATM protein is required for sustained activation of NF-kappaB following DNA damage
70. Inhibition of p53 transactivation function by the human T-cell lymphotropic virus type 1 Tax protein
71. Phosphorylation of p53: A novel pathway for p53 inactivation in human T-cell lymphotropic virus type 1-transformed cells
72. Inactivation of p53 by human T-cell lymphotropic virus type 1 requires activation of the NF-κB pathway and is dependent on p53 phosphorylation
73. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma
74. The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells
75. Stabilization of wild-type p53 in human T-lymphocytes transformed by HTLV-I
76. A human T-cell leukemia virus Tax variant incapable of activating NF-kappaB retains its immortalizing potential for primary T-lymphocytes
77. Mutational analysis of human T-cell leukemia virus type 2 Tax
78. The tax gene of human T-cell leukemia virus type 2 is essential transformation of human T lymphocytes
79. Tax protein of human T-lymphotropic virus type I triggers DNA damage
80. Roles of p300, pocket proteins, and hTBP in E1A-mediated transcriptional regulation and inhibition of p53 transactivation activity
81. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine
82. The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines
83. CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein
84. Direct evidence that p40x of human T-cell leukemia virus type I is a trans-acting transcriptional activator
85. Mutational analysis of human T-cell leukemia virus type I Tax: Regions necessary for function determined with 37 mutant proteins
86. HTLV-I and HTLV-II Tax: Differences in induction of micronuclei in cells and transcriptional activation of viral LTRs
87. Type I human T cell leukemia virus tax protein transforms rat fibroblasts through the cyclic adenosine monophosphate response element binding protein/activating transcription factor pathway
88. Structural aspects of the p53 protein in relation to gene evolution
89. The transactivator tax of human T-cell leukemia virus type 1 (HTLV- 1) interacts with cAMP-responsive element (CRE) binding and CRE modulator proteins that bind to the 21-base-pair enhancer of HTLV-1
90. Tax oncoprotein of HTLV-1 binds to the human homologue of Drosophila discs large tumor suppressor protein, hDLG, and perturbs its function in cell growth control
91. p53 stabilization and functional impairment in the absence of genetic mutation or the alteration of the p14(ARF)-MDM2 loop in ex vivo and cultured adult T-cell leukemia/lymphoma cells
92. Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro
93. Transcriptional repression of p53 by human T-cell leukemia virus lype 1 Tax protein
94. Binding of p53 to the KIX domain of CREB binding protein. A potential link to human T-cell leukemia virus, type I-associated leukemogenesis
95. Binding of the human T-cell leukemia virus Tax protein to the coactivator CBP interferes with CBP-mediated transcriptional control
96. HTLV-I Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerization
97. ATM-dependent activation of p53 involves dephosphorylation and association with 14-2-2 proteins
98. HTLV-1 21 bp repeat sequences facilitate stable association between Tax and CREB to increase CREB binding affinity
99. Complex formation between CREB and Tax enhances the binding affinity of CREB for the human T-cell leukemia virus type 1 21-base-pair repeats
100. Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease
101. Isolation of full-length ATM cDNA and correction of the ataxia-telangectasia cellular phenotype
102. Human T-cell lymphotropic virus type I (HTLV-I) transcriptional activator, Tax, enhances CREB binding to HTLV-I 21-base-pair repeats by protein-protein interaction
103. Interaction of the human T-cell lymphotrophic virus type I (HTLV-I) transcriptional activator Tax with cellular factors that bind specifically to the 21-base-pair repeats in the HTLV-I enhancer