Identification of novel targets for cancer therapy using expression proteomics

Leukemia

Volumn 16, Issue 4, 2002, Pages 478-485

  Hanash, S M ^a   Madoz Gurpide, J ^a   Misek, D E ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Cancer; Microarray; Op18; Proteomics; Therapeutics

Indexed keywords

ANTINEOPLASTIC AGENT; ONCOPROTEIN; PROTEOME;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; CANCER THERAPY; CONTROLLED STUDY; DRUG RESEARCH; DRUG TARGETING; GENE EXPRESSION PROFILING; GENE MUTATION; GENE SEQUENCE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN TARGETING; PROTEOMICS; REVIEW;

ANTINEOPLASTIC AGENTS; BIOTECHNOLOGY; DRUG DESIGN; GENE EXPRESSION PROFILING; HUMANS; LEUKEMIA; MOLECULAR BIOLOGY; MOLECULAR DIAGNOSTIC TECHNIQUES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEOME;

EID: 0036241045     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2402412     Document Type: Review

References (68)

1. Biomedical applications of two-dimensional electrophoresis using immobilized pH gradients: Current status
2. Mass spectrometry and proteomics
3. Isoelectric focusing in immobilized pH gradients: Principle, methodology, and some applications
4. High resolution two-dimensional polyacrylamide gel electrophoresis of basic polypeptides: Use of immobilized pH gradients in the first dimension
5. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
6. Epidermal growth factor receptor tyrosine kinase as a target for anticancer therapy
7. Membrane proteomics: Use of additive main effects with multiplicative interaction model to classify plasma membrane proteins according to their solubility and electrophoretic properties
8. Mass spectrometric characterization of proteins extracted from jurkat T cell detergent-resistant membrane domains
9. Imaging mass spectrometry: A new technology for the analysis of protein expression in mammalian tissues
10. A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library
11. Protein microarrays for gene expression and antibody screening
12. Analysis of yeast protein kinases using protein chips
13. Antibody arrays for high-throughput screening of antibody-antigen interactions
14. UPA, a universal protein array system for quantitative detection of protein-protein, protein-DNA, protein-RNA, and protein-ligand interactions
15. An array immunosensor for simultaneous detection of clinical analytes
16. High-throughput microarray-based enzyme-linked immunosorbent assay (ELISA)
17. Mass-sensing multianalyte microarray immunoassay with imaging detection
18. Protein microchips: Use for immunoassay and enzymatic reactions
19. Protein microarrays for highly parallel detection and quantitation of specific proteins and anti-bodies in complex solutions
20. Printing proteins as microarrays for high-throughput function determination
21. Inaugural article: Immunoassays with rolling circle DNA amplification: A versatile platform for ultrasensitive antigen detection
22. Tissue microarrays for high-throughput molecular profiling of tumor specimens
23. Tissue microarray technology for high-throughput molecular profiling of cancer
24. Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front
25. Protein-based microarrays: A tool for probing the proteome of cancer cells and tissues
26. Quantitative monitoring of gene expression patterns with a complementary microarray
27. Use of a cDNA microarray to analyse gene expression patterns in human cancer
28. Modulation of electroenzymatic NADPH oxidation through oriented immobilization of ferredoxin: NADP(+) reductase onto modified gold electrodes
29. Immobilization of antibodies on a photoactive self-assembled monolayer on gold
30. Attempts to mimic docking processes of the immune system: Recognition-induced formation of protein multilayers
31. Lineage related polypeptide markers in acute lymphoblastic leukemia detected by two-dimensional electrophoresis
32. Genetic analysis of thirty three platelet polypeptides detected in two-dimensional polyacrylamide gels
33. Acute lymphoblastic leukemia in infants less than one year of age: A cumulative experience of the Children's Cancer Study Group
34. Clinical and biologic features predict a poor prognosis in acute lymphoid leukemias in infants: A Pediatric Oncology Group study
35. Identification of a cellular polypeptide that distinguishes between acute lymphoblastic leukemia in infants and in older children
36. Identification of two related markers for common acute lymphoblastic leukemia as heat shock proteins
37. Correlation of clinical data with proteomics profiles in 24 patients with B-cell chronic lymphocytic leukemia
38. Molecular cloning of a novel human leukemia associated gene: Evidence of conservation in animal species
39. Maximum likelihood estimation of receiver operating characteristics (ROC) curves from continuously distributed data
40. Characterization of the gene for a proliferation related phosphoprotein (Op18) expressed in high amounts in acute leukemia
41. N-myc gene amplification in neuroblastoma is associated with altered phosphorylation of a proliferation related polypeptide (Op18)
42. Quantitative analysis of Op18 phosphorylation in childhood acute leukemia
43. Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules
44. Stathmin: A tubulin-sequencing protein which forms a ternary T2S complex with two tubulin molecules
45. Control of microtubule dynamics by oncoprotein 18: Dissection of the regulatory role of multisite phosphorylation during mitosis
46. The microtubule-destabilizing activity of metablastin (p19) is controlled by phosphorylation
47. Stathmin expression is a feature of proliferating cells of most if not all cell lineages
48. Human peripheral lymphocyte growth regulation and response to phorbol esters is linked to synthesis and phosphorylation of the cytosolic protein prosolin
49. Cell cycle progression is associated with distinct patterns of phosphorylation of Op18
50. Activation of resting peripheral blood lymphocytes through the T cell receptor induces rapid phosphorylation of Op18
51. The stathmin phosphoprotein family: Intracellular localization and effects on the microtubule network
52. Multiple phosphorylation of stathmin. Identification of four sites phosphorylated in intact cells and in vitro by cyclic AMP-dependent protein kinase and p34cdc2
53. G2/M transition requires multisite phosphorylation of oncoprotein 18 by two distinct protein kinase systems
54. Serine 25 of oncoprotein 18 is a major cytosolic target for the mitogen-activated protein kinase
55. Serine 16 of oncoprotein 18 is a major cytosolic target for the Ca2+/calmodulin-dependent kinase-Gr
56. Molecular characterization of human stathmin expressed in Escherichia coli: Site-directed mutagenesis of two phosphorylatable serines (Ser-25 and Ser-63)
57. Stathmin: A relay phosphoprotein for multiple signal transduction?
58. Oncoprotein 18 is a phosphorylation-responsive regulator of microtubule dynamics
59. Identification of a polypeptide associated with the malignant phenotype in acute leukemia
60. Expression of oncoprotein 18 in human leukemias and lymphomas
61. Quantitative analysis of the expression and regulation of an activation-regulated phosphoprotein (oncoprotein 18) in normal and neoplastic cells
62. Overexpression of stathmin in breast carcinomas points out to highly proliferative tumours
63. Oncogenic mutation of the microtubule regulator Op18
64. Involvement of Op18 in cell proliferation
65. Antisense RNA inhibition of phosphoprotein p18 expression abrogates the transformed phenotype of leukemic cells
66. Oncoprotein 18 overexpression increases the sensitivity to vindesine in the human lung carcinoma cells
67. Stathmin inhibition enhances okadaic acid-induced mitotic arrest. A potential role for stathmin in mitotic exit
68. Post-translational modifications