RhoGDI-3 regulates RhoG and targets this protein to the Golgi complex through its unique N-terminal domain

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Volumn 3, Issue 5, 2002, Pages 342-358

  Brunet, Nicolas ^a   Morin, Annie ^a   Olofsson, Birgitta ^a  

^a LABORATOIRE D ENZYMOLOGIE ET BIOCHIMIE STRUCTURALES   (France)

Author keywords

Golgi; Rho proteins; RhoG; rhoGDI 3; rhoGDIs

Indexed keywords

DETERGENT; GREEN FLUORESCENT PROTEIN; GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; MUTANT PROTEIN; PEPTIDE; RAB PROTEIN; RAC PROTEIN; RHO FACTOR;

AMINO TERMINAL SEQUENCE; CELL FRACTIONATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; GOLGI COMPLEX; HUMAN; HUMAN CELL; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN STABILITY; PROTEIN TARGETING; REVIEW; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; CELL MEMBRANE; GOLGI APPARATUS; GUANINE NUCLEOTIDE DISSOCIATION INHIBITORS; HELA CELLS; HUMANS; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; PROTEIN TRANSPORT; RHO GTP-BINDING PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0036240521     PISSN: 13989219     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0854.2002.30504.x     Document Type: Review

References (49)

1. Ras and Rho GTPases: A family reunion
2. Rho proteins: Linking signaling with membrane trafficking
3. Small GTP-binding proteins
4. Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins
5. The identification and characterization of a GDP-dissociation inhibitor (GDI) for the CDC42Hs protein
6. Functional interactions of stimulatory and inhibitory GDP/GTP exchange proteins and their common substrate small GTP-binding protein
7. Rho guanine dissociation inhibitors: Pivotal molecules in cellular signalling
8. Activation of NADPH oxidase involves the dissociation of p21 rac from its inhibitory GDP/GTP exchange protein (rhoGDI) followed by its translocation to the plasma membrane
9. Role of bound GDP in the stability of the rho A-rho GDI complex purified from neutrophil cytosol
10. Maintenance of CDC42 GDP-bound state by Rho-GDI inhibits MAP kinase activation by the exchange factor Ras-GRF, evidence for Ras-GRF function being inhibited by Cdc42-GDP but unaffected by CDC42-GTP
11. Differential localization of Rho GTPases in live cells: Regulation by hypervariable regions and RhoGDI binding
12. Phosphoinositide-dependent activation of Rho A involves partial opening of the RhoA/Rho-GDI complex
13. Expression level, subcellular distribution and Rho-GDI binding affinity of merlin in comparison with ezrin/radixin/moesin proteins
14. Purification and characterization from bovine brain cytosol of a novel regulatory protein inhibiting the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP-binding protein
15. cDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the rho GTP-binding proteins
16. Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, Is expressed preferentially in lymphocytes
17. RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG
18. RhoGDI, gamma: A GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas
19. Differential properties of D4/LyGDI versus RhoGDI. Phosphorylation and rho GTPase selectivity
20. C-terminal binding domain of rho GDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases
21. A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm
22. How RhoGDI binds Rho
23. Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI
24. The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI
25. Crystal structure of the Rac1-RhoGDI complex involved in NADPH oxidase activation
26. Ultrastructural localization of ras-related proteins using epitope-tagged plasmids
27. RhoG GTPase controls a pathway that independently activates Rac1 and Cdc42Hs
28. rab5 controls early endosome fusion in vitro
29. Rab4 and Rab7 define distinct nonoverlapping endosomal compartments
30. Sorting of lysosomal membrane glycoproteins lamp-1 and lamp-2 into vesicles distinct from mannose 6-phosphate receptor/gamma-adaptin vesicles at the trans-Golgi network
31. Small GTP-binding protein associated with Golgi cisternae
32. The small GTP-binding protein Rab6 is distributed from medial Golgi to the trans-Golgi network as determined by confocal microscopy
33. Fusogenic domains of golgi membranes are sequestered into specialized regions of the stack that can be released by mechanical fragmentation
34. Endoplasmic reticulum and cis-Golgi localization of human T-lymphotropic virus Type 1 p12(I): Association with calreticulin and calnexin
35. The small GTP-binding protein rab6p is redistributed in the cytosol by brefeldin A
36. Regulation of Ras-related RhoB protein expression during the cell cycle
37. Regulation of epidermal growth factor receptor traffic by the small GTPase rhoB
38. The ras-related small GTP-binding protein RhoB is immediate-early inducible by DNA damaging treatments
39. TrioGEF1 controls Rac- and Cdc42-dependent cell structures through the direct activation of RhoG
40. Development of the multiple sequence approximation within the Agadir model of α-helix formation? comparison with Zimm-Bragg and Lifson-Roig formalisms
41. The hydrophobic-staple motif and a role for loop-residues in alpha-helix stability and protein folding
42. The folding and stability of human alpha class glutathione transferase A1-1 depend on distinct roles of a conserved N-capping box and hydrophobic staple motif
43. Characterization of a cis-Golgi matrix protein, GM130
44. D4-GDI, a substrate of CPP32, is proteolyzed during Fas-induced apoptosis
45. Cleavage and nuclear translocation of the caspase 3 substrate Rho GDP-dissociation inhibitor. D4-GDI, during apoptosis
46. Kinectin is a key effector of RhoG microtubule-dependent cellular activity
47. Regulation of Rho protein binding to membranes by rhoGDI: Inhibition of releasing activity by physiological ionic conditions
48. Mammalian Cdc42 is a brefeldin A-sensitive component of the Golgi apparatus
49. Effects of N-terminal cystein mutation on prolactin expression and secretion in transfected pituitary cells