Synthesis, biological activity and molecular modeling studies of 1,2,3,4-tetrahydroisoquinoline derivatives as conformationally constrained analogues of KN62, a potent antagonist of the P2X7-receptor containing a tyrosine moiety

Arzneimittel-Forschung/Drug Research

Volumn 52, Issue 4, 2002, Pages 273-285

  Baraldi, Pier Giovanni ^a   Makaeva, Rimma ^a   Pavani, Maria Giovanna ^a   Del Carmen Nuñez, Maria ^a   Spalluto, Giampiero ^a   Moro, Stefano ^a   Falzoni, Simonetta ^a   Di Virgilio, Francesco ^a   Romagnoli, Romeo ^a  

^a UNIVERSITY OF FERRARA   (Italy)

Author keywords

1,2,3,4 Tetrahydroisoquinoline derivatives; 1 (N,O Bis 1,5 isoquinolinesuffonyl) N methyl L tyrosyl 4 phenylpiperazine; CAS 127191 97 3; KN62,analogues; Purinergic P2X7 antagonist

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; 3 (N PHENYLPIPERAZIN 4 YLCARBONYL) 2 (5 ISOQUINOLINYLSULFONYL) 7 (NAPHTHALENESULFONYLOXY) 1,2,3,4 TETRAHYDROISOQUINOLINE; 3 (N PHENYLPIPERAZIN 4 YLCARBONYL) 2 DANSYL 7 (DANSYLOXY) 1,2,3,4 TETRAHYDROISOQUINOLINE; 3 (N PHENYLPIPERAZIN 4 YLCARBONYL) 7 (5 ISOQUINOLINYLSULFONYLOXY) 1,2,3,4 TETRAHYDROISOQUINOLINE; PURINE P2X RECEPTOR; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG CONFORMATION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MEMBRANE PERMEABILITY; MOLECULAR MODEL; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 0036230156     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1299891     Document Type: Article

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