Intravenous immunoglobulin (IVIG) preparations induce apoptosis in TNF-α-stimulated endothelial cells via a mitochondria-dependent pathway

Clinical and Experimental Immunology

Volumn 127, Issue 3, 2002, Pages 445-454

  Nakatani, K ^a   Takeshita, S ^a   Tsujimoto, H ^a   Sekine, I ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

Author keywords

Apoptosis; Bcl 2; Endothelial cells; Intravenous immumoglobulin

Indexed keywords

DNA; FAS ANTIBODY; IMMUNOGLOBULIN; MONOCLONAL ANTIBODY; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; CELL DEATH; CELL LINE; CELL STIMULATION; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; MITOCHONDRION; MORPHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UMBILICAL VEIN;

ANTIGENS, CD95; APOPTOSIS; CASPASES; CELLS, CULTURED; CYSTEINE PROTEINASE INHIBITORS; ENDOTHELIUM, VASCULAR; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULINS, INTRAVENOUS; KINETICS; MEMBRANE POTENTIALS; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036228997     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2002.01769.x     Document Type: Article

References (61)

1. Endothelial cells in physiology and in the pathophysiology of vascular disorders
2. Hemostatic properties of normal and perturbed vascular cells
3. Endothelial apoptosis: Could it have a role in the pathogenesis and treatment of disease?
4. Mechanisms and functions of cell death
5. Molecular regulation of apoptosis: Genetic control on cell death
6. Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation
7. Tumor necrosis factor induces apoptosis (programmed cell death) in normal endothelial cells in vitro
8. Evidence for the involvement of endothelial cell integrin alpha Vbeta3 in the disruption of the tumor vasculature induced by TNF and IFN-gamma
9. Hydrogen peroxide induces up-regulation of Fas in human endothelial cells
10. Transforming growth factor beta 1 induces apoptotic cell death in cultured human umbilical vein endothelial cells with down-regulated expression of bcl-2
11. Fibroblast growth factor-2 inhibits endothelial cell apoptosis by Bcl-2-dependent and independent mechanisms
12. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation
13. Endothelin-1 as an autocrine/paracrine apoptosis survival factor for endothelial cells
14. Endostatin induces endothelial cell apoptosis
15. Multiple forms of angiostatin induce apoptosis in endothelial cells
16. Mechanisms of action of antimalarials in inflammation: Induction of apoptosis in human endothelial cells
17. Apoptosis, basic mechanisms and implications for cardiovascular disease
18. The proto-oncogene Bcl-2 and its role in regulating apoptosis
19. A role for reactive oxygen species in endothelial cell anoikis
20. Intravenous immunoglobulin for prevention of bacterial infections in children with symptomatic human immunodeficiency virus infection
21. High-dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura in childhood
22. Intravenous immune globulin therapy for neurologic diseases
23. High-dose intravenous gammaglobulin for Kawasaki disease
24. Mechanisms of immunoglobulin action: Observations on Kawasaki syndrome and RSV prophylaxis
25. Manipulating the immune system with immune globulin
26. Therapeutic preparations of normal polyspecific IgG (IVIg) induce apoptosis in human lymphocytes and monocytes: A novel mechanism of action of IVIg involving the Fas apoptotic pathway
27. Phosphorylation of Bcl-2 and mitochondrial changes are associated with apoptosis of lymphoblastoid cells induced by normal immunoglobulin G
28. Modulation of endothelial cell function by normal polyspecific human intravenous immunoglobulins: A possible mechanism of action in vascular diseases
29. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria
30. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
31. p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2
32. Fas ligation triggers apoptosis in macrophages but not endothelial cells
33. TNFα regulation of Fas ligand expression on the vascular endothelium modulates leukocyte extravasation
34. Bcl-2 and Bcl-XL serve an anti-inflammatory function in endothelial cells through inhibition of NF-kappaB
35. Endothelial cell death induced by tumor necrosis factor-alpha is inhibited by the Bcl-2 family member, A1
36. Tumor necrosis factor-alpha and lipopolysaccharide induce apoptotic cell death in bovine glomerular endothelial cells
37. Vitamin C and E prevent lipopolysaccharide-induced apoptosis in human endothelial cells by modulation of Bcl-2 and Bax
38. Evidence that tumor necrosis factor triggers apoptosis in human endothe-lial cells by interleukin-1-converting enzyme-like protease-dependent and -independent pathways
39. Induction of endothelial cell apoptosis by TNF alpha: Modulation by inhibitors of protein synthesis
40. Activation and injury of endothelial cells by cytokines
41. Basic fibroblast growth factor selectively enhances TNF-alpha-induced apoptotic cell death in glomerular endothelial cells: Effects on apoptotic signaling pathways
42. The role of antiapoptotic Bcl-2 family members in endothelial apoptosis elucidated with antisense oligonucleotides
43. Monocytes stimulate expression of the Bcl-2 family member, A1, in endothelial cells and confer protection against apoptosis
44. Intravenous immunoglobulin therapy
45. Pooled human IgG modulates cytokine production in lymphocytes and monocytes
46. Antibodies to a conserved region of HLA class I molecules, capable of modulating CD8 T cell-mediated function, are present in pooled normal immunoglobulin for therapeutic use
47. Anti-cytokine nature of natural human immunoglobulin: One possible mechanism of the clinical effect of intravenous immunoglobulin therapy
48. Inhibition of IL-12 synthesis of peripheral blood mononuclear cells (PBMC) stimulated with a bacterial superantigen by pooled human immunoglobulin: Implications for its effect on Kawasaki disease (KD)
49. PAK2 is cleaved and activated during hyperosmotic shock-induced apoptosis via a caspase-dependent mechanism: Evidence for the involvement of oxidative stress
50. Endothelial cell apoptosis is accelerated by inorganic iron and heat via an oxygen radical dependent mechanism
51. Introduction of apoptosis by high proinsulin and glucose in cultured human umbilical vein endothelial cells is mediated by reactive oxygen species
52. Rac1 inhibits TNF-alpha-induced endothelial cell apoptosis: Dual regulation by reactive oxygen species
53. Mediators from the endothelial cell and their participation in inflammation
54. Chemokines and chemokine receptors: Biology and clinical relevance in inflammation and AIDS
55. Control of vascular permeability by polymorphonuclear leukocytes in inflammation
56. Egr-1 mediates extracellular matrix-driven transcription of membrane type 1 matrix metalloproteinase in endothelium
57. Mechanisms of endothelial cell injury in acute inflammation
58. Endothelial-dependent procoagulant and anticoagulant mechanisms. Recent advances in understanding
59. Endothelial cell apoptosis in angiogenesis and vessel regression
60. Apoptotic vascular endothelial cells become procoagulant
61. Mannitol at clinical concentrations activates multiple signaling pathways and induces apoptosis in cendothelial cells