Effects of nimesulide and sodium diclofenac on interleukin-6, interleukin-8, proteoglycans and prostaglandin E2 production by human articular chondrocytes in vitro

Clinical and Experimental Rheumatology

Volumn 17, Issue 2, 1999, Pages 151-160

  Henrotin, Y E ^c   Labasse, A H ^c   Simonis, P E ^c   Zheng, S X ^c   Deby, G P ^a   Famaey, J P ^b   Crielaard, J M R ^c   Reginster, J Y L ^c  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b Therabel Pharma Belgium   (Belgium)

^c NONE

Author keywords

Chondrocytes; Cytokines; Diclofenac; Nimesulide; Osteoarthritis

Indexed keywords

DICLOFENAC; INTERLEUKIN 6; INTERLEUKIN 8; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN E2; PROTEOGLYCAN;

ARTICLE; CARTILAGE CELL; DRUG EFFECT; DRUG MECHANISM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; RHEUMATOID ARTHRITIS;

ADOLESCENT; ADULT; AGED; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; DICLOFENAC; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; INTERLEUKIN-1; INTERLEUKIN-6; INTERLEUKIN-8; INTERLEUKINS; KNEE JOINT; MALE; MIDDLE AGED; PROTEOGLYCANS; SULFONAMIDES;

EID: 0032966727     PISSN: 0392856X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. MARTEL-PELLETIER J, ZAFARULLAH M, KODAMA S, PELLETIER J-P: In vitro effects of interleukin-1 on synthesis of metalloproteases, TIMP, plasminogen activators and inhibitors in human articular cartilage. J Rheumatol 1991; 18 (Suppl. 27): 80-4.
2. TIKU M, LIESCH J, ROBERTSON F: Production of hydrogen peroxide by rabbit articular chondrocytes. Enhancement by cytokines. J Immunol 1990; 145: 690-6.
3. GOLDRING MB, BIRKHEAD J, SANDELL LJ et al.: Interleukin-1 supresses expression of cartilage specific type II and IX collagens and increases type I and III collagens by human chondrocytes. J Clin Invest 1988; 82: 2026-37.
4. HENROTIN Y, DE GROOTE D, LABASSE A et al.: Effects of exogenous IL-1β, TNFα, IL-6, IL-8 and LIF on cytokines production by human articular chondrocytes. Osteoarthritis Cartilage 1996; 4: 163-73.
5. BRANDT K: Effects of non-steroidal anti-inflammatory drugs on chondrocyte metabolism in vitro and in vivo. Am J Med 1987; 83: 29-34.
6. DINGLE JT: Cartilage maintenance in osteoarthritis: Interaction of cytokines, NSAID and prostaglandins in articular cartilage damage and repair. J Rheumatol 1991; 18: 30-7.
7. RASHAD S, REVELL P, HEMINGWAY A et al.: Effect of non-steroidal anti-inflammatory drugs on the course of OA. Lancet 1989; 2: 519-21.
8. PALMOSKI M, BRANDT K: Aspirin aggravates the degeneration of canine joint cartilage caused by immobilization. Arthritis Rheum 1982; 25: 1332-42.
9. KUNKEL SL, CHENSUE SW: Arachidonic acid metabolites regulates interleukin-1 production. Biochem Biophys Res Commun 1985; 128: 892-7.
10. DINGLE JT: Prostaglandins in human cartilage metabolism. J Lipid Mediators 1993; 6: 310-2.
11. DAVID MJ, VIGNON E, PESCHARD MJ et al.: Effect of non-steroidal anti-inflammatory drugs (NSAIDs) on glycosyltransferase activity from human osteoarthritic cartilage. Br J Rheumatol 1992; 31 (Suppl. 1): 13-7.
12. MAHMUD T, RAFI S, SCOTT DL et al.: Nonsteroidal antiinflammatory drugs and uncoupling of mitochondrial oxidative phosphorylation. Arthritis Rheum 1996; 39: 1998-2003.
13. VIGNON E, MATHIEU P, LOUISOT P, RICHARD M: In vitro effect of nonsteroidal antiinflammatory drugs on proteoglycanase and collagenase activity in human osteoarthritic cartilage. Arthritis Rheum 1991; 34: 1332-7.
14. YAMADA H, KIKUCHI T, NEMOTO O et al.: Effects of indomethacin on production of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 by human chondrocytes. J Rheumatol 1996; 23: 1739-43.
15. FAMAEY J-P: In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: An overview. Inflamm Res 1997; 46: 437-46.
16. -) production by human polymorphonuclear leukocytes. In GENAZZANI AR, NAPPI G, FACCHINETTI F, MARTIGNONI E (Eds.): Pain and Reproduction, Parthenon Publishing Group 1993; 265-72.
17. CASOLARO V, MELIOTA S, MARINO O et al.: Nimesulide, a sulfonanilide nonsteroidal antiinflammatory drug, inhibits mediator release from human basophils and mast cells. J Pharmacol Exp Ther 1993; 267: 1375-85.
18. FERERIA SH: The role of interleukins and nitric oxide in the mediation of inflammatory pain and its control by peripheral analgesics. Drugs 1993; 46 (Suppl 1): 1-9.
19. VERHOEVEN AJ, TOOL ATJ, KUIJPERS TW, ROOS D: Nimesulide inhibits platelet-activating factor synthesis in activated neutrophils. Drugs 1993; 46 (Suppl. 1): 52-8.
20. BEVILACQUA M, VAGO T, BALDI G et al.: Nimesulide decreases superoxide production by inhibiting phosphodiesterase type IV. Eur J Pharmacol 1994; 268: 415-23.
21. DALLEGRI F, OTTONELLO L, DAPINO P, BEVILACQUA M: The anti-inflammatory drug nimesulide rescues alpha-1-proteinase inhibitor from oxidative inactivation by phagocytosing neutrophils. Respiration 1992; 59: 1-4.
22. FACINO M, CARINI M, ALDINI G: Antioxidant activity of nimesulide and its main metabolites. Drugs 1993; 46 (Suppl. 1): 15-21.
23. DREISER RL, RIEBENFELD D: Nimesulide in the treatment of osteoarthritis. Double-blind studies in comparison with piroxicam, ketoprofen and placebo. Drugs 1993; 46 (Suppl. 1) 191-5.
24. PELLETIER J-P, MARTEL-PELLETIER J: Effects of nimesulide and naproxen on the degradation and metalloprotease synthesis of human osteoarthritic cartilage. Drugs 1993;46 (Suppl. 1): 34-9.
25. MOSKOWITZ R, DAVIS W, SANMARCO J et al.: Experimentally induced degenerative joint lesions following partial menisectomy in the rabbit. Arthritis Rheum 1973; 16: 397-466.
26. DAVIS R, BROGDEN RN: Nimesulide. An update of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs 1994; 48: 431-54.
27. AZIZ K: Pharmacokinetic of diclofenac and misoprostol when administrated alone or as a combination product. Drugs 1993; 45 (Suppl. 1): 7-14.
28. eme éd. AHFS (American Hospital Formulary service). Drug Information 1990; 1008.
29. GYSEN P, FRANCHIMONT P: Radioimmunoassay of human proteoglycans. J Immunoassay 1984; 5: 221-43.
30. VAITUKAITIS J, ROBBINS JB, NIESCHLAG E, ROSS GT: A method for producing specific antisera with small doses of immunogen. J Clin Endocrinol Metab 1971; 33: 988-91.
31. 125I-labelled human growth hormone of high specific radioactivity. Biochem J 1963; 89: 114-24.
32. 2 production. Vet Res Comm 1988; 12 : 219-26.
33. DE GROOTE D, ZANGERLE PF, GEVAERT Y et al.: Direct stimulation of cytokines (IL-1β, TNFα, IL-6, IL-2, IFN and GM-CSF) in whole blood. Comparison with isolated PBMC stimulation. Cytokine 1992; 4: 239-48.
34. LABARCA C, PAIGEN K: A simple, rapid and sensitive DNA assay procedure. Anal Biochem 1980; 102: 344-52.
35. 2 release from cartilage in organ culture. Arthritis Rheum 1989; 32: 228-97.
36. BENTON HP, TYLER JA: Inhibition of cartilage proteoglycan synthesis by interleukin-1. Biochem Biophys Res Commun 1988; 154: 421-8.
37. MITROVIC D, MCCALL E, FRONT P et al.: Antiinflammatory drugs, prostanoids and proteoglycan production by cultured bovine articular chondrocytes. Protaglandins 1984; 28: 417-34.
38. MALEMUD CJ, PAPAY RS, HASLER P, KAME GM: The effect of nonsteroidal anti-inflammatory drugs on cAMP-dependent protein kinase-mediated phosphorylation by human chondrocytes in culture. Clin Exp Rheumatol 1994; 12: 149-56.
39. VIGDAHL RL, TUKEY RH: Mechanism of action of novel anti-inflammatory drugs diflumidone and R-805. Biochem Pharmacol 1977; 26: 307-11.
40. BOTTCHER I, SCHWEIZER A, GLATT M, WENER H: A sulphonamidiindanone cGP 28237 (ZK 34228), a novel non-steroidal antiinflammatory agent without gastrointestinal ulcerogenicity in rats. Drugs Under Experimental and Clinical Research 1987; 13: 237-45.
41. SMITH RL, KAJIYAMA G, LANE N: Nonsteroidal antiinflammatory drugs: effects on normal and interleukin 1 treated human articular chondrocyte metabolism in vitro. J Rheumatol 1995; 22: 1130-7.
42. PELLETIER J-P, MINEAU F, FERNANDES J et al.: Two NSAIDs, nimesulide and naproxen, can reduce the synthesis of urokinase and IL-6 while increasing PAI-1, in human OA synovial fibroblasts. Clin Exp Rheumatol 1997; 15: 393-8.
43. NIETFIELD JJ, WILBRINK B, HELLE M et al.: Interleukin-1 induced interleukin-6 is required for the inhibition of proteoglycan synthesis by interleukin-1 in human articular cartilage. Arthritis Rheum 1990; 33: 818-26.
44. LOTZ M, GUERNE P: Interleukin-6 induces the synthesis of tissue inhibitor of metalloproteases-1/Erythroid potentiating activity (TIMP-1/EPA). J Biol Chem 1991; 266: 2017-20.