Recognition of IgG-derived peptides by a human IgM with an unusual combining site

Scandinavian Journal of Immunology

Volumn 55, Issue 3, 2002, Pages 242-255

  Yuriev, E ^b   Ramsland, P A ^c   Edmundson, A B ^a  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b MONASH UNIVERSITY   (Australia)

^c AUSTIN RESEARCH INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CRYOGLOBULIN; DOCKING PROTEIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; IMMUNOGLOBULIN M; OCTAPEPTIDE; RHEUMATOID FACTOR;

AMINO ACID SEQUENCE; ANTIBODY COMBINING SITE; ANTIBODY ISOLATION; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; GERM LINE; HUMAN; IMMUNOGLOBULIN STRUCTURE; IMMUNOGLOBULIN VARIABLE REGION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SOMATIC MUTATION; WALDENSTROEM MACROGLOBULINEMIA;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; BINDING SITES, ANTIBODY; CRYOGLOBULINS; HUMANS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN CONFORMATION; RHEUMATOID FACTOR; WALDENSTROM MACROGLOBULINEMIA;

EID: 0036226997     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0300-9475.2002.01032.x     Document Type: Article

References (52)

1. Mapping IgG epitopes bound by rheumatoid factors from immunized controls identifies disease-specific rheumatoid factors produced by patients with rheumatoid arthritis
2. IgG rheumatoid factors and staphylococcal protein A bind to a common molecular site on IgG
3. Antigenic specificities of human monoclonal and polyclonal IgM rheumatoid factors. The C gamma 2-C gamma 3 interface region contains the major determinants
4. + B cells from patients with rheumatoid arthritis
5. Rheumatoid factors from patients with rheumatoid arthritis react with beta 2-microglobulin
6. Rheumatoid factors from patients with rheumatoid arthritis react with tryptophan 60 and 95, lysine 58, and arginine 97, on human beta 2-microglobulin
7. Rheumatoid factor autoantibodies in health and disease
8. Rheumatoid factor
9. Prospective study of the early course of rheumatoid arthritis in young adults: Comparison of patients with and without rheumatoid factor positivity at entry and identification of variables correlating with outcome
10. Hidden rheumatoid factor and Wa idiotype expression in juvenile rheumatoid arthritis
11. Incipient myelomatosis or 'essential' hyperglobulinemia with fibrinogenopenia - A new syndrome?
12. Strategies for epitope analysis using peptide synthesis
13. Binding of synthetic peptides by a human monoclonal IgM with an unusual combining site structure
14. Interference of rheumatoid factor activity by aspartame, a dipeptide methyl ester
15. Rheumatoid-factor-reactive sites on CH2 established by analysis of overlapping peptides of primary sequence
16. 3 established by overlapping 7-mer peptide epitope analysis
17. An unusual human IgM antibody with a protruding HCDR3 and high avidity for its peptide ligands
18. Docking of combinatorial peptide libraries into a broadly cross-reactive human IgM
19. Principles and pitfalls in designing site-directed peptide ligands
20. Similar binding properties of peptide ligands for a human immunoglobulin and its light chain dimer
21. WHAT IF: A molecular modeling and drug design program
22. Three-dimensional structure of a human immunoglobulin with a hinge deletion
23. Critical evaluation of search algorithms for automated molecular docking and database searching
24. Automated flexible ligand docking method and its application for database search
25. Flexible ligand docking: A multistep strategy approach
26. Satisfying hydrogen bonding potential in proteins
27. LIGPLOT: A program to generate schematic diagrams of protein-ligand interactions
28. Kabat database and its applications: 30 Years after the first variability plot
29. Accessing the Kabat antibody sequence database by computer
30. Monoclonal IgM rheumatoid factors bind IgG at a discontinuous epitope comprised of amino acid loops from heavy-chain constant-region domains 2 and 3
31. Structure of human IgM rheumatoid factor Fab bound to its autoantigen IgG Fc reveals a novel topology of antibody-antigen interaction
32. Convergent solutions to binding at a protein-protein interface
33. The binding of opioid peptides to the Mcg light chain dimer: Flexible keys and adjustable locks
34. Frequent somatic mutations in D and/or JH segments of Ig gene in Waldenström's macroglobulinemia and chronic lymphocytic leukemia (CLL) with Richter's syndrome but not in common CLL
35. Human IgM molecules that bind staphylococcal protein A contain VHIII H chains
36. Human rheumatoid factor cross-idiotypes. IV. Studies on WA XId-positive IgM without rheumatoid factor activity provide evidence that the WA XId is not unique to rheumatoid factors and is distinct from the 17.109 and G6 XIds
37. A new method for the detection of hidden IgM rheumatoid factor in patients with juvenile rheumatoid arthritis
38. Molecular dissection of protein antigens and the prediction of epitopes
39. Mechanisms of antibody binding to a protein
40. A role for surface hydrophobicity in protein-protein recognition
41. Intrinsic and extrinsic factors in protein antigenic structure
42. Binding of peptides to proteins: An exercise in molecular design
43. Mechanism of allergenic cross-reactions - IV. Evidence for participation of aromatic residues in the ligand binding site of two multi-specific IgE monoclonal antibodies
44. Evidence that human immunoglobulin M rheumatoid factors can be derived from the natural autoantibody pool and undergo an antigen driven immune response in which somatically mutated rheumatoid factors have lower affinities for immunoglobulin G Fc than their germline counterparts
45. The structure and origin of rheumatoid factors
46. Similar patterns of V kappa gene usage but different degrees of somatic mutation in hairy cell leukemia, prolymphocytic leukemia, Waldenström's macroglobulinemia, and myeloma
47. Analysis of antibody reactivities toward self antigens of IgM of patients with Waldenstrom's macroglobulinemia
48. A single germline VH gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus erythematosus
49. Anatomy of the antibody molecule
50. Three-dimensional structure of an Fv from a human IgM immunoglobulin
51. The antibody problem