Evidence that human immunoglobulin M rheumatoid factors can be derived from the natural autoantibody pool and undergo an antigen driven immune response in which somatically mutated rheumatoid factors have lower affinities for immunoglobulin G Fc than their germline counterparts

Scandinavian Journal of Immunology

Volumn 51, Issue 4, 2000, Pages 327-336

  Carayannopoulos, M O ^a   Potter, K N ^a   Li, Y ^a   Natvig, J B ^b   Capra, J D ^c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G; RHEUMATOID FACTOR;

ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; BINDING AFFINITY; CELL SURVIVAL; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE DELETION; GERMINAL CENTER; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MOLECULAR CLONING; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBODY AFFINITY; ANTIBODY FORMATION; ARTHRITIS, RHEUMATOID; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS; RHEUMATOID FACTOR;

EID: 0034003356     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.2000.00731.x     Document Type: Article

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