Interference of rheumatoid factor activity by aspartame, a dipeptide methyl ester

Journal of Molecular Recognition

Volumn 12, Issue 4, 1999, Pages 249-257

  Ramsland, Paul A ^a   Movafagh, Bahereh F ^b   Reichlin, Morris ^b   Edmundson, Allen B ^a  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b Oklahoma Medical Research Foundation ^*

Author keywords

Antibody inhibition; Antibody modeling; Aspartame; Rheumatoid arthritis; Rheumatoid factors

Indexed keywords

ASPARTAME; CRYOGLOBULIN; DISEASE DIAGNOSIS; DRUG ADMINISTRATION; IMMUNOGLOBULIN GENE; RHEUMATOID ARTHRITIS; RHEUMATOID FACTOR;

ANTIRHEUMATIC AGENT; ASPARTAME; CALCIUM; CRYOGLOBULIN; DIPEPTIDE; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; RHEUMATOID FACTOR; CRYOGLOBULIN M;

ADULT; AGED; ANTIGEN ANTIBODY COMPLEX; ARTICLE; AUTOIMMUNE DISEASE; CHEMICAL STRUCTURE; COMPUTER SIMULATION; CRYOGLOBULINEMIA; DRUG EFFECT; FEMALE; HUMAN; IMMUNOLOGY; MALE; METABOLISM; MIDDLE AGED; PROTEIN CONFORMATION; RHEUMATOID ARTHRITIS;

ADULT; AGED; AGED, 80 AND OVER; ANTIGEN-ANTIBODY COMPLEX; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; ASPARTAME; AUTOIMMUNE DISEASES; CALCIUM; COMPUTER SIMULATION; CRYOGLOBULINEMIA; CRYOGLOBULINS; DIPEPTIDES; FEMALE; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MALE; MIDDLE AGED; MODELS, MOLECULAR; PROTEIN CONFORMATION; RHEUMATOID FACTOR;

EID: 0033153878     PISSN: 09523499     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1352(199907/08)12:4<249::AID-JMR463>3.0.CO;2-B     Document Type: Article

References (39)

1. Abola, E. E., Bernstein, F. C., Bryant, S. H., Koetzle, T. F. and Weng, J.(1987). PDB. In Crystallographic Databases - Information Content, Software Systems, Scientific Applications (Bergerhoff, A. G. and Sievers, R., eds.), pp. 107-132. Data Commission of the International Union of Crystallography, Bonn.
2. Bonagura, V. R., Agostino, N., Borretzen, M., Thompson, K. M., Natvig, J. B. and Morrison, S. L. (1998). Mapping IgG epitopes bound by rheumatoid factors from immunized controls identifies disease-specific rheumatoid factors produced by patients with rheumatoid arthritis. J. Immunol. 160, 2496-2505.
3. Brünger, A. T. (1992). X-PLOR Version 3.1 - a System for X-ray crystallography and NMR, Yale University Press, New Haven, CT.
4. Burastero, S. E., Casali, P., Wilder, R. L. and Notkins, A. L. (1988). Monoreactive high affinity and polyreactive low affinity rheumatoid factors are produced by CD5+ B cells from patients with rheumatoid arthritis. J. Exp. Med. 168, 1979-1992.
5. Burastero, S. E., Cutolo, M., Dessi, V. and Celada, F. (1990). Monoreactive and polyreactive rheumatoid factors produced by in vitro Epstein-Barr virus-transformed peripheral blood and synovial B lymphocytes from rheumatoid arthritis patients. Scand. J. Immunol. 32, 347-357.
6. Colman, P. M., Laver, W. G., Varghese, J. N., Baker, A. T., Tulloch, P. A., Air, G. M. and Webster, R. G. (1987). Three-dimensional structure of a complex of antibody with influenza virus neuraminidase. Nature 326, 358-363.
7. Corper, A. L., Sohi, M. K., Bonagura, V. R., Steinitz, M., Jefferis, R., Feinstein, A., Beale, D., Taussig, M. J. and Sutton, B. J. (1997). Structure of a human IgM rheumatoid factor Fab bound to its autoantigen IgG Fc reveals a novel topology of antibody-antigen interaction. Nature Struct. Biol. 4, 374-381.
8. Edmundson, A. B. and Manion, C. V. (1998). Treatment of osteoarthritis with aspartame. Clin. Pharmac. Ther. 63, 580-593.
9. Edmundson, A. B., Harris, D. L., Fan, Z.-C., Guddat, L. W., Schley, B. T., Hanson, B. L., Tribbick, G. and Geysen, H. M. (1993). Principles and pitfalls in designing site-directed peptide ligands. Proteins: Struct. Funct. Genet. 16, 246-267.
10. Eisenberg, R. (1976). The specificity and polyvalency of binding of a monoclonal rheumatoid factor. Immunochemistry 13, 355-359.
11. Fields, B. A., Goldbaum, F. A., Dall'Acqua, W., Malchiodi, E. L., Cauerhff, A., Schwartz, F. P., Ysern, X., Poljak, R. J. and Mariuzza, R. A. (1996). Hydrogen bonding and solvent structure in an antigen-antibody interface. Crystal structures and thermodynamic characterization of three Fv mutants complexed with lysozyme. Biochemistry 35, 15494-15503.
12. Geysen, H. M., Rodda, S. J., Mason, T. J., Tribbick, G. and Schoofs, P. G. (1987). Strategies for epitope analysis using peptide synthesis. J. Immunol. Meth. 102, 259-274.
13. Hay, F. C., Nineham, L. J. and Roitt, I. M. (1975). Routine assay for detection of IgG and IgM anti-globulins in seronegative and seropositive rheumatoid arthritis. Br. Med. J. 3, 203-204.
14. Herron, J. N., He, X. M., Ballard, D. W., Blier, P. R., Pace, P. E., Bothwell, A. L. M., Voss Jr, E. W. and Edmundson, A. B. (1991). An autoantibody to single-stranded DNA: comparison of the three-dimensional structures of the unliganded Fab and a deoxynucleotide-Fab complex. Proteins: Struct. Funct. Genet. 11, 159-175.
15. Ilowite, N. T., Wedgwood, J. F., Moore, T. L., Ramakrishnan, T. and Bonagura, V. R. (1991). Hidden rheumatoid factor and Wa idiotype expression in juvenile rheumatoid arthritis. Scand. J. Immunol. 34, 453-460.
16. Kabat, E. A., Wu, T. T., Perry, H. M., Gottesman, K. S. and Foeller, C. (1991). Sequences of Proteins of Immunological Interest. 5th ed., Department of Health and Human Services, Public Health Service, National Institutes of Health, Bethesda, MD.
17. Koradi, R., Billeter, M. and Wuthrich, K. (1996). MOLMOL: a program for display and analysis of macromolecular structures. J. Mol. Graph. 14, 51-55.
18. Levine, P. R. and Alexrod, D. A. (1985). Rheumatoid factor isotypes following immunization. Clin. Exp. Immunol. 3, 147-149.
19. Mannik, M. (1992). Rheumatoid factors in the pathogenesis of rheumatoid arthritis. J. Rheumatol. 19 (Supplement 32), 46-49.
20. Mantovani, L., Wilder, R. L. and Casali, P. (1993). Human rheumatoid B-1a (CD5 + B) cells make somatically hypermutated high affinity IgM rheumatoid factors. J. Immunol. 151, 473-488.
21. Masi, A. T., Maldonado-Cocco, J. A., Kaplan, S. B., Feigenbaum, S. L. and Chandler, R. W. (1976). Prospective study of the early course of rheumatoid arthritis in young adults: comparison of patients with and without rheumatoid factor positivity at entry and identification of variables correlating with outcome. Semin. Arthrit. Rheumatol. 5, 299-326.
22. Mellors, R. C., Heimer, R., Coros, J. and Korngold, L. (1959). Cellular origin of rheumatoid factor. J. Exp. Med. 110, 875-886.
23. Nardella, F. A., Teller, D. C., Barber, C. V. and Mannik, M. (1985). IgG rheumatoid factors and staphylococcal protein A bind to a common molecular site on IgG. J. Exp. Med. 162, 1811-1824.
24. Ramsland, P. A., Guddat, L. W., Edmundson, A. B. and Raison, R. L. (1997). Diverse binding site structures revealed in homology models of polyreactive immunoglobulins. J. Comput. Aided Mol. Des. 11, 453-461.
25. Ramsland, P. A., Brock, C. R., Moses, J., Robinson, B. G., Edmundson, A. B. and Raison, R. L. (1999). Structural aspects of human IgM antibodies expressed in chronic B lymphocytic leukemia. Immunotechnology 4, 217-229.
26. Robbins, D. L., Feigal, D. W. and Leek, J. C. (1986a). Relationship of serum IgG rheumatoid factor to IgM rheumatoid factor and disease activity in rheumatoid arthritis. J. Rheumatol. 13, 259-262.
27. Robbins, D. L., Feigal, D. W., Leek, J. C., Shapiro, R. and Wiesner, K. (1986b). Complement activation by 19S IgM rheumatoid factor: relationship to disease activity in rheumatoid arthritis. J. Rheumatol. 13, 33-38.
28. Roussel, A. and Cambillau, C. (1989). TURBO-FRODO molecular graphics program. In Silicon Graphics Geometry Partner Directory (Fall 1989), pp. 77-78. Silicon Graphics, Mountain View, CA.
29. Sasso, E. H., Barber, C. V., Nardella, F. A., Yount, W. J. and Mannik, M. (1988). Antigenic specificities of human monoclonal and polyclonal IgM rheumatoid factors. J. Immunol. 140, 3098-3107.
30. Sato, Y., Sato, R., Watanabe, H., Kogure, A., Watanabe, K., Nishimaki, T., Kasukawa, R., Kuraya, M. and Fujita, T. (1993). Complement activating properties of monoreactive and polyreactive IgM rheumatoid factors. Ann. Rheum. Dis. 52, 795-800.
31. Stone, M. J. and Metzger, H. (1968). Binding properties of a Waldenström macroglobulin antibody. J. Biol. Chem. 243, 5977-5984.
32. Suzuki, Y. and Mizushima, Y. (1997). Osteoporosis in rheumatoid arthritis. Osteoporo. Int. 7(Supplement 3), S217-S222.
33. Tribbick, G., Edmundson, A. B., Mason, T. J. and Geysen, H. M. (1989). Similar binding properties of peptide ligands for a human immunoglobulin and its light chain dimer. Mol. Immunol. 26, 625-635.
34. Tsuzaka, K., Leu, A. K., Barton Frank, M., Movafagh, B. F., Koscec, M., Winkler, T. H., Kalden, J. R. and Reichlin, M. (1996). Lupus autoantibodies to double-stranded DNA cross-react with ribosomal protein S1. J. Immunol. 156, 1668-1675.
35. Waldenström, J. (1944). Incipient myelomatosis or "essential" hyperglobulinemia with fibrinogenopenia - a new syndrome? Acta Med. Scand. 127, 216-224.
36. Williams, R. C. (1992). Rheumatoid factors: historical perspective, origins and possible role in disease. J. Rheumatol. 19 (Supplement 32), 42-45.
37. Williams, R. C., Malone, C. C. and Tsuchiya, N. (1992). Rheumatoid factors from patients with rheumatoid arthritis react with β2-microglobulin. J. Immunol. 149, 1104-1113.
38. Williams, R. C., Malone, C. C. and Harley, J. B. (1993). Rheumatoid factors from patients with rheumatoid arthritis reactive with tryptophan 60 and 95, lysine 58, and arginine 97, on human β2-microglobulin. Arthrit. Rheum. 36, 916-926.
39. Winchester, R. J., Agnello, V. and Kunkel, H. G. (1970). Gammaglobulin complexes in synovial fluids of patients with rheumatoid arthritis: partial characterization and relationship to lowered complement levels. Clin. Exp. Immunol. 6, 689-706.