The C-terminus of IcmT is essential for pore formation and for intracellular trafficking of Legionella pneumophila within Acanthamoeba polyphaga

Molecular Microbiology

Volumn 43, Issue 5, 2002, Pages 1139-1150

  Molmeret, Maëlle ^a,b   Alli, O A Terry ^a   Radulic, Marina ^c   Susa, Milorad ^d   Doric, Miljenko ^c   Kwaik, Yousef Abu ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITÉ LYON 1   (France)

^c UNIVERSITY OF RIJEKA   (Croatia)

^d UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACANTHAMOEBA; ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GROWTH; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXICITY; FEMALE; GENE REPLICATION; LEGIONELLA PNEUMOPHILA; LYSOSOME; MOUSE; MOUSE STRAIN; NONHUMAN; PHAGOSOME; PHENOTYPE; PNEUMONIA; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; WILD TYPE;

ACANTHAMOEBA; ANIMALS; BACTERIAL PROTEINS; CELL ADHESION; FEMALE; HUMANS; LEGIONELLA PNEUMOPHILA; LEGIONNAIRES' DISEASE; LYSOSOMES; MICE; PHAGOSOMES; U937 CELLS;

ACANTHAMOEBA; ACANTHAMOEBA POLYPHAGA; ANIMALIA; BACTERIA (MICROORGANISMS); LEGIONELLA; LEGIONELLA PNEUMOPHILA; MAMMALIA; NEGIBACTERIA; PROTOZOA;

EID: 0036223705     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2002.02842.x     Document Type: Article

References (43)

1. Fatal attraction of mammalian cells to Legionella pneumophila
2. The use of differential display-PCR to isolate and characterize a Legionella pneumophila locus induced during the intracellular infection of macrophages
3. Phenotypic modulation by Legionella pneumophila upon infection of macrophages
4. Invasion of protozoa by Legionella pneumophila and its role in bacterial ecology and pathogenesis
5. Signal transduction in the protozoan host Hartmannella vermiformis upon attachment and invasion by its bacterial parasite, the Legionnaires' disease agent, Legionella micdadei
6. Temporal pore formation-mediated egress from macrophages and alveolar epithelial cells by Legionella pneumophila
7. Legionnaires' disease: Pathological and historical aspects of a 'new' disease
8. Replicative Legionella pneumophila lung infection in intratracheally inoculated A/J mice: A murine model of human Legionnaires' disease
9. Expression of Legionella pneumophila virulence traits in response to growth conditions
10. Bacterial type IV secretion: Conjugation systems adapted to deliver effector molecules to host cells
11. Activation of caspase-3 in Legionella pneumophila-induced apoptosis in macrophages
12. Apoptosis in macrophages and alveolar epithelial cells during early stages of infection by Legionella pneumophila and its role in cytopathogenicity
13. The mechanism of killing and exiting the protozoan host Acanthamoeba polyphaga by Legionella pneumophila
14. Hijacking the apoptotic pathways of the host cell by bacterial pathogens
15. The modulation of host cell apoptosis by intracellular bacterial pathogens
16. Utilization of similar mechanisms by Legionella pneumophila to parasitize two evolutionarily distant hosts, mammalian and protozoan cells
17. Identification of macrophage-specific infectivity loci (mil) of Legionella pneumophila that are not required for infectivity of protozoa
18. Different fates of Legionella pneumophila pmi and mil mutants within human-derived macrophages and alveolar epithelial cells
19. Heterogeneity in intracellular replication and cytopathogenicity of Legionella pneumophila and Legionella mic-dadei in mammalian and protozoan cells
20. Distinct mechanisms for K+ efflux, intoxication, and hemolysis by Bordetella pertussis AC toxin
21. An essential role for therep helicase of Legionella pneumophila in the intracellular infection
22. The Legionnaires' disease bacterium (Legionella pneumophila) inhibits phagosome-lysosome fusion in human monocytes
23. Electron microscopic examination of the inflammatory response to Legionella pneumophila in guinea pigs
24. Evidence for pore-forming ability by Legionella pneumophila
25. The transfer region of IncI1 plasmid R64: Similarities between R64 tra and Legionella icm/dot genes
26. icmT is essential for pore formation-mediated egress of Legionella pneumophila from mammalian and protozoan cells
27. HtrA homologue of Legionella pneumophila: An indispensable element for intracellular infection of mammalian but not protozoan cells
28. Preliminary report on the pathogenicity of Legionella pneumophila for freshwater and soil amoebae
29. Current views on the relationships between amoebae, legionellae and man
30. Characterization of a new region required for macrophage killing by Legionella pneumophila
31. Intracellular multiplication and human macrophage killing by Legionella pneumophila are inhibited by conjugal components of IncQ plasmid RSF1010
32. Legionella pneumophila utilizes the same genes to multiply within Acanthamoeba castellanii and human macrophages
33. Host cell killing and bacterial conjugation require overlapping sets of genes within a 22-kb region of the Legionella pneu-mophila chromosome
34. Relationships between a new type IV secretion system and the icm/dot virulence system of Legionella pneumophila
35. Expression of multiple pili byLegionella pneumophila: Identification and characterization of a type IV pilin gene and its role in adherence to mammalian and protozoan cells
36. Natural competency for DNA uptake by Legionella pneumophila and its association with expression of type IV pili
37. Legionella pneumophila replication vacuoles mature into acidic, endocytic organelles
38. Legionella pneumophila infection in intratracheally inoculated T cell depleted or non-depleted A/J mice
39. Identification of a Gal/GalNAc lectin in the protozoan Hartmannella vermiformis as a potential receptor for attachment and invasion by the Legionnaires' disease bacterium, Legionella pneumophila
40. Identification of putative cytoskeletal protein homologues in the protozoan Hartmannella vermiformis as substrates for induced tyrosine phosphatase activity upon attachment to the Legionnaires' disease bacterium, Legionella pneumophila
41. Conjugative transfer by the virulence system of Legionella pneumophila
42. The pathology of Legionnaires' disease: Fourteen fatal cases from the 1977 outbreak in Vermont
43. TraK protein of conjugative plasmid RP4 forms a specialized nucleoprotein complex with the transfer origin