Involvement of nitric oxide and prostaglandins in gastroprotection induced by bacterial lipopolysaccharide

Scandinavian Journal of Gastroenterology

Volumn 33, Issue 7, 1998, Pages 691-700

  Konturek, P Ch ^a   Brzozowski, T ^b   Sliwowski, Z ^b   Pajdo, R ^b   Stachura, J ^b   Hahn, E G ^b   Konturek, S J ^b  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b NONE

Author keywords

Constitutive nitric oxide synthase; Gastric blood flow; Gastroprotection; Helicobacter pylori; Inducible nitric oxide synthase mRNA; Lipopolysaccharide; Nitric oxide; Nitric oxide synthase

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; NITRIC OXIDE; PROSTAGLANDIN E2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ENDOTOXEMIA; ESCHERICHIA COLI; IMMUNOSTIMULATION; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; STOMACH LESION; STOMACH MUCOSA;

ANALYSIS OF VARIANCE; ANIMALS; ARGININE; BASE SEQUENCE; DEXAMETHASONE; DINOPROSTONE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ESCHERICHIA COLI; ETHANOL; GASTRIC ACID; GASTRIC MUCOSA; GENE EXPRESSION; LIPOPOLYSACCHARIDES; MALE; MOLECULAR SEQUENCE DATA; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PENICILLAMINE; PEPSIN A; POLYMERASE CHAIN REACTION; RATS; RATS, WISTAR; REGIONAL BLOOD FLOW; RNA, MESSENGER; STOMACH; STOMACH DISEASES;

EID: 0031851055     PISSN: 00365521     EISSN: None     Source Type: Journal    
DOI: 10.1080/00365529850171611     Document Type: Article

References (34)

1. Rietschel ET, Brade L, Ladler B, Zahringer U. Biochemistry of lipopolysaccharides. In: Morrison DC, Ryan JL, editors. Bacterial endotoxic lipopolysaccharides. Vol. 1. Molecular biochemistry and cellular biology. Boca Raton (FL): CRC Press; 1992. p. 3-41.
2. Moran AP. Structure-bioactivity relationships of bacterial endotoxins. J Toxicol Toxin Rev 1994;14:47-83.
3. Nikaido H, Vaara M. Outer membrane. In: Neidhardt FC, editors. Escherichia coli and Salmonella typhimurium: cellular and molecular biology, Vol. 1. Washington (DC): American Society for Microbiology; 1987. p. 7-22.
4. Rietschel ET, Brade H, Holst O, Brade L, Muller-Loennies S, Mamat U, et al. Molecular structure of bacterial endotoxin in relation to bioactivity. In: Nowotny A, Spitzer JJ, Ziegler EJ, editors. Endotoxin research series, Vol. 1. Cellular and molecular aspects of endotoxin reactions. Amsterdam: Elsevier Science; 1990. p. 15-32.
5. Rietschel ET, Brade L, Schade U, Seydel U, Zahringer U, Mamat U, et al. Bacterial endotoxins: relationships between chemical structure and biological activity of the inner core-lipid A domain. In: Ron EZ, Rottem S, editors. FEMS Symposium No. 51: microbiol surface components and toxins in relation to pathogenesis. New York: Plenum Press; 1991. p. 209-17.
6. Satano T, Itoh K, Tanaka M, Arakawa Y, Matsuo Y. An experimental study of gastric mucosal blood flow in endotoxenia of the rat with special reference to vagus nerve and EDRF. J Gastroenterol 1995;30:8-15.
7. Tepperman BL, Soper BD. Nitric oxide synthase induction and cytoprotection on rat gastric mucosa from injury by ethanol. Can J Physiol Pharmacol 1994;72:1308-12.
8. Barrachina MD, Calataynd S, Moreno L, Martinez-Cuesta, Whittle BJR, Espluges JV. Nitric oxide and sensory afferent neurones modulate the protective effects of low-dose endotoxin on rat gastric mucosal damage. Eur J Pharmacol 1995;280:339-42.
9. Tsuji K, Kuhara A, Santes SB, Namiki M. Endotoxin protects the gastric mucosa against ulcerogenic stimuli. Biochem Biophys Res Commun 1993;197:1326-33.
10. Brown JF, Tepperman BL, Hanson PJ, Whittle BJR, Moncada S. Differential distribution of nitric oxide synthase between cell fractions isolated from the rat gastric mucosa. Biochem Biophys Res Commun 1992;184:680.
11. Tepperman BL, Brown JF, Whittle BJR. Nitric oxide synthase induction and intestinal epithelial cell viability in rats. Am J Physiol 1993;265:G214-8.
12. Boughton-Smith NK, Evans SM, Whittle BJR, Moncada S. Induction of nitric oxide synthase in rat intestine and its association with tissue injury. Agents Actions 1993;38:C125-6.
13. 2+-independent nitric oxide synthase activity in rat gastric mucosal cells. Eur J Pharmacol 1994;292: 111-4
14. Fu J, Masferrer JL, Siebert K, Raz A, Needleman P. The induction and suppression of prostaglandin H synthase (cyclooxygenase) in human monocytes. J Biol Chem 1990;265:16737-40.
15. Xie W, Chipman JG, Robertson RL, Erikson RL, Simmons DL. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc Natl Acad Sci USA 1991;88:2692-6.
16. Konturek PCh. Physiological, immunohistochemical and molecular aspects of gastric adaptation to stress, aspirin and to H. pylori-derived gastrotoxins. J Physiol Pharmacol 1997;48:3-42.
17. Corbett JA, Kwon G, Turk J, McDaniel ML. IL-1β induces to coexpression of both nitric oxide synthase and cyclooxygenase by islets of Langerhans: activation of cyclooxygenase by nitric oxide. Biochemistry 1993;32:13767-70.
18. Salvemini D, Manning PT, Zweifel BS, Seibert K, Connor J, Currie MG, et al. Dual inhibition of nitric oxide and prostaglandin production contributes to the antiinflammatory properties of nitric oxide synthase inhibitors. J Clin Invest 1995;96: 301-6.
19. Stadler J, Harbrecht BG, DiSilvio M, Curran RD, Jordan ML, Simmons RL, et al. Endogenous nitric oxide inhibits the synthesis of cyclooxygenase products and interleukin-6 by rat Kupffer cell. J Leukoc Biol 1993;53:165-72.
20. Konturek SJ, Brzozowski T, Konturek PCh, Majka J, Debminski A. Role of salivary glands and epidermal growth factor in gastric secretion and mucosal integrity in rats exposed to stress. Reg Pept 1991;32:203-15.
21. 2 analog with local gastroprotective and ulcer healing activity. Eur J Pharmacol 1991;195:347-57.
22. Konturek SJ, Brzozowski T, Majka J, Szlachcic A, PytkoPolonczyk J. Implications of nitric oxide in the action of cytoprotective drugs on gastric mucosa. J Clin Gastroenterol 1993;17 Suppl 1:140-5.
23. Salvemini D, Misko TP, Seiber K, Masferrer JL, Currie MG, Needleman P. Nitric oxide activates cyclooxygenase enzymes. Proc Natl Acad Aci USA 1993;72:40-72.
24. Green LC, Tannenbaum SR, Goldman P. Nitrate synthesis in the germ-free and conventional rat. Science 1981;212:56-8.
25. Griffiths MJD, Liu S, Curzen NP, Messent M, Evans IW. In vivo treatment with endotoxin induces nitric oxide synthase in rat main pulmonary artery. Am J Physiol 1995;268:L509-18.
26. Tanoue K, Ohta M, Tarnawski AS, Wahlstrom K, Sugimmachi K, Sarfeh IJ. Portal hypertension activates the nitric oxide synthase genes in the esophageal mucosa of rats. Gastroenterology 1996;110:549-57.
27. Palmer RMJ, Bridge L, Foxwell MA, Moncada S. The role of nitric oxide in endothelial cell damage and its inhibition by glucocorticoids. Br J Pharmacol 1992;105:11.
28. Di Rosa M, Radomski M, Camuccio R, Moncada S. Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages. Biochem Biophys Res Commun 1990;172:1246-54.
29. Tepperman BL, Whittle BJR. Endogenous nitric oxide and sensory neuropeptides interact in the modulation of the rat gastric microcirculation. Br J Pharmacol 1992;105:171-5.
30. Kubes P, Kanwar S, Niu XF, Gaboury JP. Nitric oxide synthesis inhibition induces leukocyte adhesion via superoxide and mast cells. FASEB J 1993;7:1293-8.
31. Lopez-Belmonte J, Whittle BJR, Moncada S. The actions of nitric oxide donors in the prevention of induction of injury to the rat gastric mucosa. Br J Pharmacol 1993;108:73-8.
32. Konturek SJ, Konturek PCh. Role of nitric oxide in the digestive system. 1995;56:1-13.
33. Tsuji K, Uehara A, Okumura T, Taniguchi Y, Kitamori S, Takasugi Y, et al. The gastric antisecretory action of lipopolysaccharide is blocked by indomethacin. Eur J Pharmacol 1992; 210:213-5.
34. Whittle BJR, Lopez-Belmonte J, Moncada S. Regulation of gastric mucosal integrity by endogenous nitric oxide: interaction with prostanoids and sensory neuropeptides in the rat. Br J Pharmacol 1990;99:607-11.