Role of L-arginine, a substrate for nitric oxide-synthase, in gastroprotection and ulcer healing

Journal of Gastroenterology

Volumn 32, Issue 4, 1997, Pages 442-452

  Brzozowski, Tomasz ^a   Konturek, Stanislaw J ^a   Sliwowski, Zbigniew ^a   Drozdowicz, Danuta ^a   Zaczek, Marcin ^a   Kedra, Dariusz ^a  

^a JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

Angiogenesis; Gastric blood flow; Gastroprotection; L arginine; Nitric oxide; Prostaglandins; Ulcer healing

Indexed keywords

ACETYLSALICYLIC ACID; ALCOHOL; ARGININE; CAPSAICIN; CITRULLINE; DEXTRO ARGININE; GLUTAMINE; INDOMETACIN; MONOCLONAL ANTIBODY; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; ORNITHINE; PROSTAGLANDIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENERVATION; DOSE RESPONSE; DRUG EFFECT; ENZYME INHIBITION; HYPEREMIA; IMMOBILIZATION STRESS; INTRAGASTRIC DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH LESION; STOMACH MUCOSA; STOMACH SECRETION; STOMACH ULCER; ULCER HEALING;

EID: 0030747212     PISSN: 09441174     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02934081     Document Type: Article

References (37)

1. Cynober L. Can arginine and ornithine support gut functions. Gut 1994; 35(Suppl 1):S42-S45.
2. Barbul A, Lazarou SA, Efron BA, et al. Arginine enhances wound healing and lymphocyte immune responses in humans. Surgery 1990;108:331-337.
3. Ignarro LJ, Buga GM, Wood KS, et al. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 1987;84:9265-9269.
4. Palmer RMJ, Ashton DS, Moncada S. Vascular endothelial cells synthesise nitric oxide from L-arginine. Nature 1988;333:664-666.
5. Brown JF, Tepperman BL, Hanson PJ, et al. Differential distribution of nitric oxide synthase between cell fractions isolated from the rat gastric mucosa. Biochem Biophys Res Commun 1992; 184:840-868.
6. Rand MJ. Nitrergic transmission: Nitric oxide as a mediator of non-adrenergic, non-cholinergic, neuro-effector transmission. Clin Exp Pharmacol Physiol 1992;19:147-169.
7. Palmer RMJ, Rees DD, Ashton DS, et al. L-Arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation. Biochem Biophys Res Commun 1988;153:1251-1256.
8. Pique JM, Whittle BJR, Esplugues JV. The vasodilator role of endogenous nitric oxide in the rat gastric microciculation. Eur J Pharmacol 1989;174:293-296.
9. Stark ME, Szurszewski JH. Role of nitric oxide in gastrointestinal function and disease. Gastroenterology 1992;103:1928-1949.
10. Mac Naughton K, Cirino G, Wallace JL. Endothelium-derived relaxing factor (nitric oxide) has protective actions in the stomach. Life Sci 1989;45:1869-1876.
11. Wallace JL, Cirino G, De Nucci G, et al. Endothelin has potent ulcerogenic actions in the stomach. Am J Physiol 1989;256:G661-G666.
12. Brzozowski T, Drozdowicz D, Szlachcic A, et al. Role of nitric oxide and prostaglandins in gastroprotection induced by capsaicin and papaverine. Digestion 1993;54:24-31.
13. Whittle BJR, Lopez-Belmonte J, Moncada S. Regulation of gastric mucosal integrity by endogenous nitric oxide: Interactions with prostanoids and sensory neuropeptides in the rat. Br J Pharmacol 1990;99:607-611.
14. Whittle BJR, Tepperman BL. Role of the endogenous vasoactive mediators, nitric oxide, prostanoids and sensory neuropeptides in the regulation of gastric blood flow and mucosal integrity. In: Garner A, O'Brien PE (eds) Mechanism of injury, protection and repair of the upper gastrointestinal tract. Chichester: John Wiley and Sons, 1991:127-137.
15. Konturek SJ, Brzozowski T, Majka J, et al. Role of nitric oxide and prostaglandins in sucralfate-induced gastroprotection. Eur J Pharmacol 1992;211:277-279.
16. Konturek SJ, Brzozowski T, Majka J, et al. Nitric oxide in gastroprotection by aluminium-containing antacids. Eur J Pharmacol 1992;229:155-162.
17. Lopez-Belmonte J, Whittle BJR, Moncada S. The actions of nitric oxide donors in the prevention or induction of injury to the rat gastric mucosa. Br J Pharmacol 1993;108:73-78.
18. Brzozowski T, Konturek SJ, Drozdowicz D, et al. Healing of chronic gastric ulcerations by L-arginine. Role of endogenous prostaglandins, nitric oxide and polyamines. Digestion 1995; 56:463-471.
19. Konturek SJ. Mechanisms of gastroprotection. Scand J Gastroenterol 1990;25(Suppl 174):15-28.
20. Konturek SJ, Brzozowski T, Majka J, et al. Transforming growth factor alpha and epidermal growth factor in protection and healing of gastric mucosal injury. Scand J Gastroenterol 1992;27:649-655.
21. Konturek PK, Brzozowski T, Konturek SJ, et al. Role of epidermal growth factor, prostaglandin and sulfhydryls in stress-induced gastric lesions. Gastroenterology 1990;99:1607-1615.
22. Ishii KB, Chang B, Kerwin JF, et al. N-Nitro-L-arginine: a potent inhibitor of endothelium-derived relaxing factor formation. Eur J Pharmacol 1990;176:219-223.
23. 2 in rats. Digestion 1987;38:103-113.
24. Okabe S, Pfeifer CJ, Roth JLA. A method for experimental penetrating ulcers in rats. Am J Dig Dis 1971;16:277-284.
25. Brzozowski T, Konturek SJ, Majka J, et al. Involvement of nitric oxide in gastric ulcer healing with antacids. Eur J Gastroenterol Hepatol 1993;5(Suppl 3):S117-S123.
26. Sternberg LA, Hardy PH, Cuculis JJ, et al. Unlabeled antibody enzyme method for immunohistochemical preparation and properties of soluble antigen-antibody complex (horseradish-anti-horseradish peroxidase) and its use in identification spirochetes. J Histochem Cytochem 1970;18:315-333.
27. Wang JM, Kumar S, Pye D, et al. Monoclonal antibody detects heterogenity in vascular endothelium of tumors and normal tissue. Int J Cancer 1993;54:363-370.
28. Barbul A, Lazaron SA, Efron DT, et al. Arginine enhances wound healing and lymphocyte immune responses in humans. Surgery 1990;108:331-336.
29. Seifter E, Rettura G, Barbul A, et al. Arginine: An essential amino acid for injured rats. Surgery 1978;84:224-230.
30. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: Physiology, pathophysiology and pharmacology. Pharmacol Rev 1991;43:109-142.
31. Brown JF, Hanson PJ, Whittle BJR. Nitric oxide donors increase gel thickness in rat stomach. Eur J Pharmacol 1992;223:103-104.
32. Wu G, Meininger CJ. Regulation of L-arginine synthesis from L-citrulline by L-glutamine in endothelial cells. Am J Physiol 1993;265:H1965-H1971.
33. Takeuchi K, Ohucki T, Kato S, et al. Cytoprotective action of L-arginine against HCL-induced gastric injury in rats - involvement of nitric oxide. Jpn J Pharmacol 1993;61:13-21.
34. Konturek SJ, Brzozowski T, Majka J, et al. Nitric oxide in gastroprotection by sucralfate, mild irritant and nocloprost. Role of mucosal blood flow. Dig Dis Sci 1994;39:593-600.
35. Lambrecht N, Burchert M, Respondek M, et al. Role of calcitonin gene-related peptide and nitric oxide in the gastroprotective effect of capsaicin in the rat. Gastroenterology 1993;104:1371-1380.
36. Farraz JGP, Tigley A, Wallace JL. Paradoxical effects of L-arginine on gastric mucosal integrity. Eur J Pharmacol 1994; 260:107-111.
37. Konturek SJ, Brzozowski T, Majka J, et al. Inhibition of nitric oxide synthase delays the healing of chronic gastric ulcers. Eur J Pharmacol 1993;239:215-217.