Methadone and heroin antinociception: Predominant δ-opioid-receptor responses in methadone-tolerant mice

Japanese Journal of Pharmacology

Volumn 88, Issue 3, 2002, Pages 319-331

  Rady, Jodie J ^a   Portoghese, Philip S ^a   Fujimoto, James M ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Antinociception; Chronic methadone; Heroin; Methadone; Opioid receptor

Indexed keywords

2 HYDROXYSACLOFEN; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR; 7 BENZYLIDENENALTREXONE; BETA FUNALTREXAMINE; BICUCULLINE; DELTA OPIATE RECEPTOR; DELTA1 OPIATE RECEPTOR; DELTA2 OPIATE RECEPTOR; DIAMORPHINE; DIZOCILPINE; METHADONE; METHYSERGIDE; MORPHINE; MORPHINE 6 ACETATE; MU OPIATE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NALTRIBEN; PLACEBO; SEROTONIN RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; BRAIN; CONTROLLED STUDY; DRUG EFFECT; DRUG IMPLANTATION; DRUG PELLET; DRUG RECEPTOR BINDING; DRUG RESPONSE; DRUG SCREENING; DRUG SELECTIVITY; DRUG TOLERANCE; INHIBITION KINETICS; MALE; METABOLIC ACTIVATION; METHADONE TREATMENT; MOUSE; NERVOUS SYSTEM; NONHUMAN; RECEPTOR INTRINSIC ACTIVITY; RECEPTOR OCCUPANCY; RECEPTOR SENSITIVITY; RECEPTOR UPREGULATION; SPINE; TAIL FLICK TEST;

EID: 0036218366     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.88.319     Document Type: Article

References (51)

1. Heroin acts on different opioid receptors than morphine in Swiss Webster and ICR mice
2. The heroin metabolite, 6-monoacetylmorphine, activates delta opioid receptors to produce antinociception in Swiss Webster mice
3. Novel receptor mechanisms for heroin and morphine-6beta-glucuronide analgesia
4. 3-Methoxynaltrexone, a selective heroin/morphine-6beta-glucuronide antagonist
5. Morphine tolerance in mice changes response of heroin from μ to δ receptors
6. Heroin antinociception changed from mu to delta receptor in streptozotocin-treated mice
7. Antisense mapping of MOR-1 in rats: Distinguishing between morphine and morphine-6 beta-glucuronide antinociception
8. Identification and characterization of three new alternatively spliced mu-opioid receptor isoforms
9. Retention of heroin and morphine-6-beta-glucuronide analgesia in a new line of mice lacking MOR-1
10. Opioid receptor selectivity of heroin given intracerebroventricularly differs in six strains of inbred mice
11. 5]enkephalin a delta opioid agonist given intracerebroventricularly in the mouse produces antinociception through mediation of spinal GABA receptors
12. Methadone-related opioid agonist pharmacotherapy for heroin addiction. History, recent molecular and neurochemical research and future in mainstream medicine
13. Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK801
14. Pharmacological effects produced by intracerebral injections of drugs in the conscious mouse
15. 5- and morphine-induced antinociception in mice
16. Central and systemic morphine-induced antinociception in mice: Contribution of descending serotonergic and noradrenergic pathways
17. Spinal GABA receptors mediate brain delta opioid analgesia in Swiss Webster mice
18. A receptors
19. Analgesic response in offspring of crosses between heroin δ (Swiss Webster) and μ (ICR) responding mice
20. Intrathecal morphine in mice: A new technique
21. A simplified method of evaluating dose-effect experiments
22. Withdrawal tolerance and unidirectional non-cross tolerance in narcotic pellet implanted mice
23. Formulation of a morphine implantation pellet suitable for tolerance-dependence studies in mice
24. Application of the message-address concept in the design of highly potent and selective non-peptide δ opioid antagonists
25. 1-opioid receptor antagonist: 7-benzylidenenaltrexone
26. Supraspinal delta receptor subtype activity of heroin and 6-monoacetylmorphine in Swiss Webster mice
27. Lack of morphine and enkephalin tolerance in 129/SvEv mice: Evidence for a NMDA receptor defect
28. Enhanced analgesic potency and reduced tolerance of morphine in 129/SvEv mice: Evidence for a deficiency in GM1 ganglioside-regulated excitatory opioid receptor functions
29. Heroin acts on delta opioid receptors in the brain of streptozotocin-induced diabetic rats
30. Differential effects of leucine and methionine enkephalin on morphine-induced analgesia, acute tolerance and dependence
31. Mu and delta receptors: Their role in analgesia and in the differential effects of opioid peptides in analgesia
32. Beta-FNA binds irreversibly to the opiate receptor complex: In vitro and in vivo evidence
33. Modulation of μ-mediated antinociception in the mouse involves opioid delta-2 receptors
34. Oligomerization of μ- and δ-opioid receptors. Generation of novel functional properties
35. Heterodimerization of μ and δ opioid receptors: A role in opiate synergy
36. Retention of supraspinal delta-like analgesia and loss of morphine tolerance in δ opioid receptor knockout mice
37. Opioids and their complicated receptor complexes
38. Characterization of opioid receptors modulating neurogenic contractions of circular muscle from porcine ileum and evidence that δ- and κ-opioid receptors are co-expressed in myenteric neurons
39. Tolerance to morphine analgesia: Decreased multiplicative interaction between spinal and supraspinal sites
40. Morphine antinociception in different strains of mice: Relationship of supraspinal multiplicative interaction to tolerance
41. Dynorphin A(2 - 17) restores spinal/supraspinal morphine synergy in morphine tolerant mice
42. Differential analgesic cross-tolerance to morphine between lipophilic and hydrophilic narcotic agonists
43. Electroencephalographic and behavioral tolerance and cross-tolerance to morphine and methadone in rat
44. Absence of cross tolerance to heroin in morphine tolerant mice
45. Brain uptake of morphine: Pharmacological implications
46. Metabolism of heroin and its pharmacologic implications
47. The pharmacokinetics of heroin in patients with chronic pain
48. Evidence from opiate binding studies that heroin acts through its metabolites
49. Ischemic preconditioning and morphine-induced cardioprotection involve the δ-opioid receptor in the intact rat heart
50. ATP channels