Supraspinal delta2 opioid agonist analgesia in Swiss-Webster mice involves spinal GABAA receptors

Pharmacology Biochemistry and Behavior

Volumn 54, Issue 2, 1996, Pages 363-369

  Rady, Jodie J ^a   Fujimoto, James M ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

6 monoacetylmorphine; Antinociception; Delta2 opioid receptor; Descending pathway; DSLET; GABAA; GABAB

Indexed keywords

2 HYDROXYSACLOFEN; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR; BICUCULLINE; DELTA OPIATE RECEPTOR; DIAMORPHINE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; LEUCINE ENKEPHALIN[2 DEXTRO SERINE 6 THREONINE]; MORPHINE 6 ACETATE; OPIATE AGONIST; PICROTOXIN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRATHECAL DRUG ADMINISTRATION; MALE; MOUSE; NEUROTRANSMISSION; NONHUMAN; OPIATE ADDICTION; PRIORITY JOURNAL; RECEPTOR AFFINITY; SPINAL REFLEX; TAIL FLICK TEST;

AMINO ACID SEQUENCE; ANALGESICS; ANALGESICS, OPIOID; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENKEPHALIN, LEUCINE; ENKEPHALINS; GABA ANTAGONISTS; HEROIN; INJECTIONS, INTRAVENTRICULAR; INJECTIONS, SPINAL; MICE; MOLECULAR SEQUENCE DATA; MORPHINE DERIVATIVES; PAIN MEASUREMENT; RECEPTORS, GABA-A; RECEPTORS, OPIOID, DELTA; SPINAL CORD;

ANIMALIA;

EID: 0029951469     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/0091-3057(95)02150-7     Document Type: Article

References (40)

1. Advokat, C.; Burton, P. Antinociceptive effect of systemic and intrathecal morphine in spinally transected rats. Eur. J. Pharmacol. 139:355-343; 1987.
2. 3 receptor-mediated antinociception: Possible release of GABA. J. Neurosci. 11:1881-1888; 1991.
3. 5 DAMGO) and morphine-induced antinociception in mice. J. Pharmacol. Exp. Ther. 256: 890-896; 1991.
4. Berge, O.-G.; Hole, K. Tolerance to the antinociceptive effect of morphine in the spinal rat. Neuropharmacology 20:653-657; 1981.
5. Corbett, A. D.; Gillan, M. G. E.; Kosterlitz, W. W.; McKnight, A. T.; Paterson, S. J.; Robson, L. E. Selectivities of opioid peptide analogues as agonists and antagonists at the δ-receptor. Br. J. Pharmacol. 83:271-279; 1984.
6. D'Amour, F. E.; Smith, D. L. A method for determining loss of pain sensation. J. Pharmacol. Exp. Ther. 72:74-79; 1941.
7. Dewey, W. L.; Harris, L. S.; Howes, J. P.; Nuite, J. A. The effect of various neurohormonal modulators on the activity of morphine and the narcotic antagonists in the tail flick and phenyl-quinone test. J. Pharmacol. Exp. Ther. 175:435-442; 1970.
8. Fields, H. L.; Basbaum, A. J. Central nervous system mechanisms of pain modulation. In: Wall, P. D.; Melzack, R., eds. The textbook of pain. New York: Churchill Livingstone; 1994:243-257.
9. Gacel, G.; Fournie-Zaluski, M.-C.; Roques, B. P. D-Tyr-Ser-Gly-Phe-Leu-Thr, a highly preferential ligand for δ-opioid receptors. FEBS Lett. 118:245-247; 1980.
10. Haley, T. J.; McCormick, W. G. Pharmacological effects produced by intracerebral injections of drugs in the conscious mouse. Br. J. Pharmacol. 12:12-15; 1957.
11. 5]enkephalin, a delta opioid agonist, given intracerebroventricularly in the mouse produces antinociception through mediation of spinal GABA receptors. Pharmacol. Biochem. Behav. 49:675-682; 1994.
12. Hylden, J. L.; Wilcox, G. L. Intrathecal morphine in mice: A new technique. Eur. J. Pharmacol. 167:313-316; 1980.
13. 6]-enkephalin and naltrindole 5′-isothiocyanate: Evidence for delta receptor subtypes. J. Pharmacol. Exp. Ther. 257:1069-1075; 1991.
14. A receptors. J. Pharmacol. Exp. Ther. 274:730-734; 1995.
15. A receptors. Brain Res. 620: 86-96; 1993.
16. B antagonists attenuate the antinociception produced by microinjection of L-glutamate into the ventromedial medulla of the rat. Brain Res. 607:39-46; 1993.
17. Rady, J. J.; Aksu, F.; Fujimoto, J. M. The heroin metabolite, 6-monoacetylmorphine, activates delta opioid receptors to produce antinociception in Swiss-Webster mice. J. Pharmacol. Exp. Ther. 268:1222-1231; 1994.
18. Rady, J. J.; Fujimoto, J. M. Spinal GABA receptors mediate brain delta opioid analgesia in Swiss-Webster mice. Pharmacol. Biochem. Behav. 51:655-659; 1995.
19. Rady, J. J.; Roerig, S. C.; Fujimoto, J. M. Heroin acts on different opioid receptors than morphine in Swiss-Webster and ICR mice to produce antinociception. J. Pharmacol. Exp. Ther. 256: 448-457; 1991.
20. Rady, J. J.; Takemori, A. E.; Portoghese, P. S.; Fujimoto, J. M. Supraspinal delta receptor subtype activity of heroin and 6-monoacetylmorphine in Swiss-Webster mice. Life Sci. 55:603-609; 1994.
21. Sofuoglu, M.; Portoghese, P. S.; Takemori, A. E. δ-Opioid receptor binding in mouse brain: Evidence for heterogeneous binding sites. Eur. J. Pharmacol. 216:273-277; 1992.
22. Sofuoglu, M.; Portoghese, P. S.; Takemori, A. E. Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: Evidence for delta opioid receptor subtypes. J. Pharmacol. Exp. Ther. 257:676-680; 1991.
23. Steel, R. G. D.; Torrie, J. H. Principles and procedures of statistics with special reference to the biological sciences. New York: McGraw-Hill Book Company, Inc.; 1960:99-111.
24. Suh, H. H.; Fujimoto, J. M.; Tseng, L.-F. Differential mechanisms mediating β-endorphin and morphine-induced analgesia in mice. Eur. J. Pharmacol. 168:61-70; 1989.
25. Takemori, A. E.; Sultana, M.; Nagase, H.; Portoghese, P. S. Agonist and antagonist activities of ligands derived from naltrexone and oxymorphone. Life Sci. 50:1491-1495; 1992.
26. Umans, J. G.; Inturrisi, C. E. Pharmacodynamics of subcutaneously administered diacetylmorphine, 6-acetylmorphine and morphine in mice. J. Pharmacol. Exp. Ther. 218:409-415; 1981.
27. Umans, J. G.; Inturrisi, C. E. Heroin: Analgesia, toxicity and disposition in the mouse. Eur. J. Pharmacol. 85:317-323, 1982.
28. 2 receptors. J. Pharmacol. Exp. Ther. 267:449-455; 1993.
29. VonVoightlander, P. F.; Lewis, R. A.; Neff, G. L. Kappa opioid analgesia is dependent on serotonergic mechanisms. J. Pharmacol. Exp. Ther. 231:270-274; 1984.
30. Wang, F.-S.; Rady, J. J.; Fujimoto, J. M. Elimination of the antianalgesic action of dynorphin A by spinal transsection in barbital-anesthetized mice. J. Pharmacol. Exp. Ther. 268:873-880; 1994.
31. Way, E. L. Metabolism of analgesics: Pharmacological implications of some factors influencing brain uptake of morphine. Arch. Biol. Med. Exp. 4:92-104; 1967.
32. Way, E. L. Brain uptake of morphine: Pharmacological implications. Fed. Proc. 26:1115-1118; 1967.
33. Way, E. L.; Adler, T. K. The pharmacological implications of the fate of morphine and its surrogates. Pharmacol. Rev. 12:383-446; 1960.
34. Way, E. L.; Kemp, J. W.; Young, J. M.; Grassetti, D. R. The pharmacological effects of heroin in relationship to its rate of biotransformation. J. Pharmacol. Exp. Ther. 129:144-145; 1960.
35. Wigdor, S.; Wilcox, G. L. Central and systemic morphine-induced antinociception in mice: Contribution of descending serotonergic and noradrenergic pathways. J. Pharmacol. Exp. Ther. 242:90-95; 1987.
36. Yaksh, T. L. Analgetic action of intrathecal opiates in cat and primate. Brain Res. 153:205-210; 1978.
37. Yaksh, T. L. Direct evidence that spinal serotonin and noradrenaline terminals mediate the spinal antinociceptive effects of morphine in the periaqueductal grey. Brain Res. 160:180-185; 1979.
38. Yaksh, T. L.; Malmberg, A. Central pharmacology of nociceptive transmission. In: Wall, P. D.; Melzack, R., eds. The textbook of pain. New York: Churchill Livingstone; 1994:165-200.
39. Yaksh, T. L.; Rudy, T. A. Analgesia mediated by a direct spinal action of narcotics. Science 192:1357-1358; 1976.
40. Yaksh, T. L.; Rudy, T. A. Studies on the direct spinal action of narcotics in the production of analgesia in the rat. J. Pharmacol. Exp. Ther. 202:411-428; 1977.