Cerebral malaria in mice: Interleukin-2 treatment induces accumulation of γδ T cells in the brain and alters resistant mice to susceptible-like phenotype

American Journal of Pathology

Volumn 158, Issue 1, 2001, Pages 163-172

  Haque, Azizul ^a   Echchannaoui, Hakim ^a   Seguin, Rosanne ^b   Schwartzman, Joseph ^b   Kasper, Lloyd H ^b   Haque, Sakhina ^a,b  

^a Aix Marseille university   (France)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR; NITRIC OXIDE; RECOMBINANT INTERLEUKIN 2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN MALARIA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; FEMALE; GENETIC RESISTANCE; HISTOPATHOLOGY; IMMUNOPATHOLOGY; MOUSE; NONHUMAN; PLASMODIUM YOELII; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 0035144767     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63954-5     Document Type: Article

References (47)

1. A role for cytokines in potentiation of malaria vaccines through immunological modulation of blood stage infection
2. L3T4+ T lymphocytes play a major role in the pathogenesis of murine cerebral malaria
3. Participation of lymphocyte subpopulations in the pathogenesis of experimental murine cerebral malaria
4. Depletion of CD4+ or CD8+ T-cells prevents Plasmodium berghei induced cerebral malaria in end-stage disease
5. Gamma delta T-cell function in pathogenesis of cerebral malaria in mice infected with Plasmodium berghei ANKA
6. Brain capillary blockage produced by a virulent strain of rodent malaria
7. Cerebral malaria in mice: Demonstration of cytoadherence of infected red blood cells and microrheologic correlates
8. Malaria pathogenesis
9. An immunohistochemical study of the pathology of fatal malaria. Evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration
10. Tumor necrosis factor and disease severity in children with falciparum malaria
11. Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria
12. The IL-2 receptor complex: Its structure, function, and target genes
13. In vivo treatment with interleukin 2 reduces parasitemia and restores IFN-γ gene expression and T cell proliferation during acute murine malaria
14. Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids
15. IFN-γ is produced by polymorphonuclear neutrophils in human uterine endometrium and by cultured peripheral blood polymorphonuclear neutrophils
16. Immunization with heat-killed Toxoplasma gondii stimulates an early IFN-gamma response and induces protection against virulent murine malaria
17. Development of reversible lesions in the brain, heart and kidney following acute and chronic murine malaria infection
18. The spleen in malaria: The role of barrier cells
19. Role of IFN-gamma in lethal and nonlethal malaria in susceptible and resistant murine hosts
20. Possible central role of nitric oxide in conditions clinically similar to cerebral malaria
21. Association between serum levels of reactive nitrogen intermediates and coma in children with cerebral malaria in Papua New Guinea
22. Nitric oxide in Tanzanian children with malaria: Inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression
23. Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy
24. Nitric oxide: A physiologic messenger molecule
25. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells
26. Interleukin-10
27. Interleukin 10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-γ in murine macrophages
28. Elevated serum levels of IL-10 and IFN-gamma in patients with acute Plasmodium falciparum malaria
29. Interleukin-10 inhibits expression of both interferon α- and interferon γ-induced genes by suppressing tyrosine phosphorylation of STAT1
30. Correlation of increased expression of intercellular adhesion molecule-1, but not high levels of tumor necrosis factor-alpha with lethality of Plasmodium yoelii 17XL, a rodent model of cerebral malaria
31. The effect of a monoclonal antibody to tumor necrosis factor on survival from childhood cerebral malaria
32. Use of pentoxyfelline in the treatment of cerebral malaria
33. Pentoxyfelline as a supportive agent in the treatment of cerebral malaria in children
34. Evidence of blood-brain barrier dysfunction in human cerebral malaria
35. T lymphocyte entry into the central nervous system
36. Interleukin-2 (IL-2) regulates the accessibility of the IL-2-responsive enhancer in the IL-2 receptor alpha gene to transcription factors
37. The lymphocyte function associated LFA-1, CD2, and LFA-3 molecules: Cell adhesion receptors of the immune system
38. Expression and regulation of adhesion molecules by γδ T cells from lymphoid tissues and intestinal epithelium
39. Production of interferon-gamma and tumour necrosis factor-alpha by human T-cell clones expressing different forms of the gamma delta receptor
40. Differential production of interferon-gamma and interleukin-4 in response to Th1- and Th2-stimulating pathogens by gamma delta T cells in vivo
41. Gamma delta T cell-induced nitric oxide production enhances resistance to mucosal candidiasis
42. Gamma delta T cells function in cell-mediated immunity to acute blood-stage Plasmodium chabaudi adami malaria
43. Gamma delta T cells contribute to control of chronic parasitemia in Plasmodium chabaudi infections in mice
44. Gamma delta T cells are a component of early immunity against preerythrocytic malaria parasites
45. Late dominance of the inflammatory process in murine influenza by γδ T cells in vivo