Tracing transgene expression in cancer gene therapy: A requirement for rational progress in the field

Molecular Imaging and Biology

Volumn 4, Issue 1, 2002, Pages 27-33

  Sangro, Bruno ^a   Qian, Cheng ^a   Ruiz, Juan ^a   Prieto, Jesús ^a  

^a UNIVERSITY CLINIC OF NAVARRA   (Spain)

Author keywords

Adenoviral vectors; Gene expression; Gene therapy; Genetic immunotherapy; PET

Indexed keywords

ADENOVIRUS VECTOR; DNA; DOPAMINE RECEPTOR; ENZYME; GENE PRODUCT; LIGAND; LIPOSOME; NUCLEOSIDE ANALOG; RECEPTOR; RETROVIRUS VECTOR; SOMATOSTATIN RECEPTOR; THYMIDINE KINASE; VIRUS VECTOR;

ADENO ASSOCIATED VIRUS; ARTICLE; CANCER; CONTROLLED STUDY; DEGENERATIVE DISEASE; DNA VECTOR; GENE CONSTRUCT; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE THERAPY; GENE TRANSFER; GENETIC CODE; GENETIC DISORDER; GENETIC TRANSDUCTION; HERPES VIRUS; IMAGING SYSTEM; IN VIVO STUDY; INFECTION; ISOTOPE LABELING; MOLECULAR PROBE; NON INVASIVE MEASUREMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RELIABILITY; SUICIDE GENE; TRANSGENE; TUMOR CELL;

HERPESVIRIDAE;

EID: 0036207986     PISSN: 15361632     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1095-0397(01)00072-3     Document Type: Review

References (44)

1. Human gene therapy comes of age
2. The basic science of gene therapy
3. Gene therapy for
4. Functional inactivation of genes by dominant negative mutations
5. Simple RNA enzymes with new and highly specific endoribonuclease activities
6. Ribozymes
7. Basic principles of antisense therapeutics
8. Antisense RNA
9. Analysis of trans-acting response decoy RNA-mediated inhibition of human immunodeficiency virus type 1 transactivation
10. Gene transfer: A review of methods and applications
11. Long-term expression of the alphal-antitrypsin gene in mice employing anionic and cationic liposome vectors
12. Direct gene transfer into mouse muscle in vivo
13. Gene expression following direct injection of DNA into liver
14. Receptor mediated gene delivery and expression in vivo
15. Delivery of plasmid DNA to glial cells using pH-sensitive immunoliposomes
16. Development and characterization of cationic liposomes conjugated with HVJ (Sendai virus): Reciprocal effect of cationic lipid for in vitro and in vivo gene transfer
17. Retroviral vectors for liver-directed gene therapy
18. Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors
19. Development and application of adenoviral vectors for gene therapy of cancer
20. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy
21. High-capacity adenoviral vectors for gene transfer and somatic gene therapy
22. The development of adeno-associated virus as a vector for cancer gene therapy
23. Transduction of hepatocellular carcinoma (HCC) using recombinant adeno-associated virus (rAAV): In vitro and in vivo effects of genotoxic agents
24. The potential of gene therapy in the treatment of hepatocellular carcinoma
25. Gene Therapy for gastrointestinal tract cancer: A review
26. P53 tumor suppressor gene therapy for cancer
27. Gene transfer and therapy with adenoviral vector in rats with diethylnitrosamine-induced hepatocellular carcinoma
28. Gene Therapy of Orthotopic Hepatocellular Carcinoma in Rats Using Adenovirus Coding for interleukin-12 (IL-12)
29. Intratumoral coinjection of two adenoviruses, one encoding the chemokine IFN-gamma-inducible protein-10 and another encoding IL-12, results in marked antitumoral synergy
30. Adenoviral gene transfer of interleukin 12 into tumors synergizes with adoptive T cell therapy both at the induction and effector level
31. Immunotherapy of Hepatocellular Carcinoma (HCC) by Engineering Tumor Cells to Express B7-1 and/or IL-12
32. Abrogation of tumor vasculature using gene therapy
33. A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolaemia
34. Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease
35. Analysis of the relative level of gene expression from different retroviral vectors used for gene therapy
36. In situ histochemical detection of beta-galactosidase activity in lung: Assessment of X-Gal reagent in distinguishing lacZ gene expression and endogenous beta-galactosidase activity
37. Biodistribution of an adenoviral vector carrying the luciferase reporter gene following intravesical or intravenous administration to a mouse
38. Green fluorescent protein (GFP) fusion constructs in gene therapy research
39. In vivo visualization of gene expression using magnetic resonance imaging
40. Assessing gene expression in vivo: Magnetic resonance imaging and spectroscopy
41. Noninvasive monitoring of gene transfer using a reporter receptor imaged with a high-affinity peptide radiolabeled with 99mTc or 188Re
42. Repetitive, non-invasive imaging of the dopamine D2 receptor as a reporter gene in living animals
43. Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography
44. Fluoropenciclovir (8-[18F]): An improved reporter probe for imaging HSV1-tk reporter gene expression in vivo using PET