Hepatitis C virus infection, mixed cryoglobulinemia, and non-Hodgkin's lymphoma: An emerging picture

Leukemia and Lymphoma

Volumn 31, Issue 5-6, 1998, Pages 463-476

  Dammacco, Franco ^a,b   Gatti, Pietro ^a   Sansonno, Domenico ^a  

^a UNIVERSITY OF BARI MEDICAL SCHOOL   (Italy)

^b POLICLINICO   (Italy)

Author keywords

HCV; Hepatitis C virus infection; Mixed cryoglobulinemia; Non hodgkin's lymphoma

Indexed keywords

CD34 ANTIGEN; IMMUNOGLOBULIN M;

B LYMPHOCYTE; CHRONIC LIVER DISEASE; CRYOGLOBULINEMIA; GENETIC VARIABILITY; HEPATITIS C; HEPATITIS C VIRUS; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LYMPHOCYTE PROLIFERATION; LYMPHOID CELL; NONHODGKIN LYMPHOMA; OPEN READING FRAME; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; REVIEW; VIRAL GENETICS; VIROGENESIS; VIRUS REPLICATION;

EID: 0032449826     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428199809057606     Document Type: Review

References (89)

1. Choo, Q., Weiner, A.J., Overby, L.R., Kuo, G, Houghton, M, and Bradley, DW (1990) Hepatitis C virus: the major causative agent of viral non-A, non-B hepatitis. Br. Med. Bull., 46, 423-441.
2. Alter, J.A. (1995) To C or not to C: These are the questions. Blood, 85, 1681-1695.
3. Oldstone, M.B.A. (1997) How viruses escape from cytotoxic T lymphocytes: molecular parameters and players. Virology, 234, 179-185.
4. Koff, J.A. and Dienstag, J.L. (1995) Extrahepatic manifestations of hepatitis C and the association with alcoholic liver disease. Semin. Liver Dis., 15, 101-109.
5. Lamelin, J.P, Zoulin, F. and Trepo, C. (1994) Lymphotropism of hepatitis B and C viruses: an update and a new comer. Int. J. Clin. Lab. Res., 25, 1-6.
6. Sansonno, D., Cornacchiulo, V., lacobelli, A.R., Gatti, P., Distasi, M.A., and Dammacco, F. (1996) Hepatitis C virus infection and clonal B cell expansion. Clin. Exp. Rheumathol., 14, 45-50.
7. Choo, Q., Kuo, G., Weiner, A.J., Overby, L.R., Bradley, D.W. and Houghton M. (1989) Isolation of cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science, 244, 359-362.
8. Ohno, T and Lau, J.Y.N. (1996) The "Gold Standard", accuracy, and the current concepts: hepatitis C virus genotype and viremia. Hepatology, 24, 1315-1321.
9. Honda, M., Brown, E.A. and Lemon, S.M. (1996) Stability of a stem-loop involving the initiator AUG controls the efficiency of internal initiation of translation on hepatitis C virus. RNA, 2, 955-968.
10. Tsukiyama-Kohara, K., Iizuka, N., Kohara, M. and Nomoto, A. (1992) Internal ribosome entry site within hepatitis C virus RNA. J. Virol., 66, 1476-1483.
11. Yamada, N., Tanihara, K., Takada, A., Yorihuzi, T., Tsutsumi, M., Shimomura, H., Tsuji, T. and Date, T. (1996) Genetic organization and diversity of the 3′ noncoding region of the hepatitis C virus genome. Virology., 223, 255-261.
12. Major, M.E., and Feinstone, S.M. (1997) The molecular virology of hepatitis C. Hepatology., 25, 1527-1538.
13. Grakoui, A., Wychowski, C. Lin, C., Feinstone, S.M. and Rice, C.M. (1993) Expression and identification of hepatitis C virus polyprotein cleavage products. J. Virol. 67, 1385-1395.
14. Santolini, E., Migliaccio, G. and Lamonica, M. (1994) Biosynthesis and biochemical properties of the hepatitis C virus core protein. J. Virol., 68, 3631-3641.
15. Suzuki, R., Matsuura, Y., Suzuki, T., Ando, A., Chiba, J., Harada, S., Saito, L., et al. (1995) Nuclear localization of the truncated hepatitis C virus core protein with the hydrophobic C terminus deleted. J. Gen. Virol., 76, 53-61.
16. Barba, G., Harper, F., Harada, T., Kohara, M., Goulinet, S., Matsuura, Y., Eder, G., Scaff, Z., Chapman, M.J., Miyamura, T. and Brechot, C. (1997) Hepatits C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets. Proc. Natl. Acad. Sci. USA, 94, 1200-1205.
17. Miyamura, T. and Matsuura, Y. (1993) Structural proteins of hepatitis C virus. Trends Microbiol., 1, 229-231.
18. Ralstom, R., Thudium, K., Berger, K., Kuo, C., Gervase, B., Hall, J., Selby, M., Kuo, G., Houghton, M. and Choo, Q.L. (1993) Characterization of hepatitis C virus envelope glycoprotein complexes expressed by recombinant vaccinia viruses. J. Virol., 67, 6753-6761.
19. Choo, Q., Kuo, G., Ralstom, R., Weiner, A.J., Chien, D., Van Nest, G., Han, J., Berger, K., Thudium, K., Kjo, C., Kansopon, J., McFarland, J., Tabrizi, A., Ching, K., Moss, B., Cummins, L.B., Houghton, M. and Muchmore, E. (1994) Vaccination of chimpanzees against infection by the hepatitis C virus. Proc. Natl. Acad. Sci. USA, 91, 1294-1298.
20. Weiner, A.J., Geisen, H.M., Christopherson, C., Hall, J.E., Mason, T.J., Saracco, G., Bonino, F., Crawford, K., Marion, C.D., Crawford, K.A., Brunetto, M., Barr, P.J., Miyamura, T., McHutchinson, J. and Houghton, M. (1992) Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: potential role in chronic HCV infection. Proc. Natl. Acad. Sci. USA, 89, 3468-3472.
21. Shimizu, Y.K., Hijikata, M., Iwamoto, A, Alter, HJ, Purcell, R.H. and Yoshikura, H. (1994) Neutralizing antibodies against hepatitis C virus and emergence of neutralization escape mutant viruses. J. Virol., 68, 1494-1500.
22. Zibert, A., Schreier, E, and Roggendorf, M. (1995) Antibodies in human sera specific to hypervariable region 1 of hepatitis C virus can block viral attachment. Virology, 208, 653-661.
23. Grakoui, A., McCourt, D.W., Wychowki, C, Feinstone, S.M., and Rice, C.M. (1993) A second hepatitis C virus-encoded proteinase. Proc. Natl. Acad. Sci. USA, 90, 10583-10587.
24. Love, R.A., Parge, H.E., Wickersham, J.A., Hostomsky, Z., Habuka, N., Moomaw, E.W., Adachi, T. and Hostomska, Z. (1996) The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsine-like fold and a structural zinc binding site. Cell, 87, 331-342.
25. Kim, D.W., Gwack, Y., Han, J.H. and Choe, J. (1995) C terminal domain of the hepatitis C virus NS3 contains an RNA helicase activity. Biochem. Biophys. Res. Commun., 215, 160-166.
26. Hong, Z., Ferrari, E., Wright-Minogue, J., Chase, R., Risano, C., Seelig, G., Lee, C. and Kwong, A.D. (1996) Enzymatic characterization of hepatitis C virus NS3/4A complexes expressed in mammalian cells by using the herpes simplex amplicon system. J. Virol., 70, 4261-4268.
27. Lin, C., Thomson, J.A. and Rice, C.M. (1995) A central region of the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine protease complex in vivo and in vitro. J. Virol., 69, 4373-4380.
28. Tomei, L., Failla, C., Vitale, R.L., Bianchi, E. and De Francesco, R. (1995) A central hydrophobic domain of the hepatitis C virus NS4A protein is necessary and sufficient for the activation of the NS3 protease. J. Gen. Virol., 77, 1065-1070.
29. Enomoto, N., Sakuma, I., Asahina, Y., Kurosaki, M., Murakami, T., Yamamoto, C., Ogura, Y., Izumi, N., Marumo, F. and Sato, C. (1996) Mutations in nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus Ib infection. N. Engl. J. Med., 334, 77-81.
30. Behrens, S., Tomei, L. and De Francesco, R. (1996) Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus. EMBO J., 15, 12-22.
31. Lanford, R.E., Chavez, D., Chisari, F.V. and Sureau, C. (1995) Lack of detection of negative strand hepatitis C virus in peripheral blood mononuclear cells and other extrahepatic tissues by the highly strand-specific rTth reverse transcriptase BPCR. J Virol., 69, 8079-8083.
32. Lerat, H., Berby, F., Trabaud, M.A., Vidalin, O., Major, M., Trepo, C., and Inchauspe, G. (1996) Specific detection of hepatitis C viruses minus strand RNA in hematopoietic cells. J. Clin. Invest., 97, 845-851.
33. Negro, F., Pacchioni, D., Shimizu Y., Miller, R.H., Bussolati, G., Purcell, R.H., and Bonino, F. (1992) Detection of intrahepatic replication of hepatitis C virus RNA by in situ hybridization and comparison with histopathology. Proc. Natl. Acad. Sci. USA, 89, 2247-2251.
34. Yamada, S., Koji, T., Nazawa, M., Kiyasawa, K. and Nakane, P.K. (1992) Detection of hepatitis C virus (HCV) RNA in paraffin embedded tissue sections of human liver of non-A, non-B hepatitis patients by in situ hybridization. J. Clin. Lab. Anal., 6, 40-46.
35. Tanaka, Y., Enomoto, N., Kojima S., Tang, L., Goto, M., Marumo, M. and Sato, C. (1993) Detection of hepatitis C virus RNA in the liver by in situ hybridization. Liver, 12, 286-289.
36. Blight, K., Trowbridge, R., Rowland, R. and Gowans, E.J. (1992) Detection of hepatitis C virus RNA by in situ hybridization. Liver 12, 286-289.
37. Sansonno, D., Cornacchiulo, V., lacobelli, A.R., Gatti, P., Distasi, M. and Dammacco, F. (1995) Demonstration and distribution of HCV RNA sequences by in situ hybridization and HCV-related proteins by immunohistochemistry in the liver tissue of patients with chronic HCV infection. Pathobiology, 63, 239-248.
38. Yamada, G., Nishimoto, H., Endou, H., Doi, T., Takahashi, M., Tsuji, T., Yoshizawa, H., Nozawa, M., Koji, T. and Nakane, P.K. (1993) Localization of hepatitis C virus RNA and capsid protein in human liver. Dig. Dis. Sci., 38, 882-887.
39. Haruna, Y., Hayashi, N., Kamada, T., Hytiroglou, P., Thung, S.N. and Gerber, M.A. (1994) Expression of hepatitis C virus in hepatocellular carcinoma. Cancer, 73, 2253-2258.
40. Sansonno, D., Cornacchiulo V., Racanelli, V. and Dammacco F. (1997) In situ simultaneous detection of hepatitis C virus RNA and hepatitis C virus-related antigens in hepatocellular carcinoma. Cancer, 80, 22-26.
41. De Vita, S., Sansonno, D., Dolcetti, R., Ferraccioli, G., Carbone, A., Cornacchiulo, V., Santini, G., Crovatto, M., Gloghini, A. and Dammacco, F. (1995) Hepatitis C virus within a malignant lymphoma lesion in the course of type II mixed cryoglobulinemia. Blood, 86, 1887-1892.
42. Sansonno, D., Cornacchiulo, V., lacobelli, A.R., Di Stefano, R., Lospalluti, M. and Dammacco, F. (1995) Localization of hepatitis C virus antigens in liver and skin tissues of chronic hepatitis C virus-infected patients with mixed cryoglobulinemia. Hepalology, 21, 305-312.
43. Gabrielli, A., Manzin, A., Candela, M., Caniglia, M.L., Paolucci, S., Danieli, G. and Clementi, M. (1994) Active hepatitis C virus infection in bone marrow and peripheral blood mononuclear cells from patients with mixed cryoglobulinemia. Clin. Exp. Immunol., 97, 87-93.
44. Moldvay, J., Deny, P., Pol, S., Brechet, C. and Lamas, E. (1994) Detection of hepatitis C virus RNA in peripheral blood mononuciear cells of infected patients by in situ hybridization. Blood, 83, 269-273.
45. Muratori, L., Gibellini, D., Lenzi, M., Cataleta, M., Muratori, P., Morelli, M.C. and Bianchi, F.B. (1996) Quantification of hepatitis C virus-infected peripheral blood mononuclear cells by in situ reverse transcriptase-polymerase chain reaction. Blood, 88, 2768-2774.
46. Sansonno, D., and Dammacco, F. (1993) Hepatitis C virus c100 antigen in liver tissue from patients with acute and chronic infection. Hepatology, 18, 240-245.
47. Sansonno, D., lacobelli, A.R., Cornacchiulo, V., lodice, G. and Dammacco, F. (1996) Detection of hepatitis C virus (HCV) proteins by immunofluorescence and HCV RNA genomic sequences by non-isotopic in situ hybridization in bone marrow and peripheral blood mononuclear cells of chronically HCV-infected patients. Clin. Exp. Immunol, 103, 414-421.
48. Peiris, J.S.M. and Porterfield, J.S. (1979) Antibody-mediated enhancement of Flavivirus replication in macrophage-like cell lines. Nature, 282, 509-511.
49. Sansonno, D., lacobelli, A.R., Cornacchiulo, V., Lauletta, G., Distasi, M.A., Gatti, P., and Dammacco, F. (1996) Immunochemical and biomolecular studies of circulating immune complexes isolated from patients with acute and chronic hepatitis C virus infection. Eur. J. Clin. Invest., 26, 465-475.
50. Fujii, K., Hino, K., Okazaki, M., Okuda, M., Kondoh, S. and Okita, K. (1996) Differences in hypervariable region 1 quasispecies of hepatitis C virus between human serum and peripheral blood mononuclear cells. Biochem. Bioph. Res. Comm., 225, 771-776.
51. Chang, T.T., Young, K.C., Yang, Y.J., Lei, H.Y. and Wu, H.L. (1996) Hepatitis C virus RNA in peripheral blood mononuclear cells: comparing acute and chronic hepatitis C virus infection. Hepatology, 23, 977-981.
52. + hematopoietic progenitor cells in HCV chronic carriers. Blood, (in press).
53. Taniguchi, H., Toyoshima, T., Fukao, K and Nakauchi, H. (1996) Presence of hematopoietic stem cells in the adult liver. Nature. 2, 198-203.
54. Krause, D.S., Fackler, M.J., Civin, C.I. and Strafford, M.W. (1996) CD34: structure, biology, and clinical utility. Blood, 87, 1-13.
55. Monteverde, A., Sabattini, E., Poggi, S., Ballarè, M. Bertoncelli, M.C., De Vivo, A., Briskomatis, A., Roncador, A., Falini, B. and Pileri, S.A. (1996) Bone marrow findings further support the hypothesis that essential mixed cryoglobulinemia type II is characterized by a monoclonal B-cell proliferation. Leuk. Lymphoma, 20, 119-124.
56. Liu, Y.J. and Banchereau, J. (1996) The paths and the molecular controls of peripheral B-cell development. The Immunologist, 4, 55-66.
57. McCarthy, K.P., Sloane, J.P. and Wiedmann, L.M. (1990) Rapid method for distinguishing clonal from polyclonal B cell populations in surgical biopsy specimens. J. Clin. Pathol., 43, 429-432.
58. Knight, G.B., Agnello, V., Bonagura, F., Barnes, J.L., Panka, D.J. and Zang, Q.X. (1993) Human rheumatoid factor cross-idiotypes. IV. Studies on WA Xld-positive IgM without rheumatoid factor activity provide evidence that the WA Xld is not unique to rheumatoid factor and is distinct from the 17.109 and G6 Xld. J. Exp. Med., 178, 1903-1911.
59. Sigounas, G., Kolaitis, N., Monell-Torrens, E. and Notkins, A.L. (1994) Polyreactive IgM antibodies in the circulation are masked by antigen binding. J. Clin. Imnmnol., 14, 375-381.
60. Lee, S.K., Bridges, S.L., Kirkham, P.M., Koopman, W.J. and Schroeder, H.W. (1994) Evidence of antigen receptor-influenced oligoclonal B lymphocyte expansion in the synovium of a patient with long-standing rheumatoid arthritis. J. Clin. Invest., 93, 361-370.
61. Tsiagbe, V.K., Inghirami, G. and Thorbecke, G.J. (1996) The physiology of germinal centers. Critical Rev. Immunol., 16, 381-386.
62. Schroder, A.E., Greiner, A., Seyfert, C. and Berek, C. (1996) Differentiation of B cells in nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis. Proc. Natl. Acad. Sci. USA, 93, 221-225.
63. Levo, Y., Gorevic, P.D., Kassab, H.J., Tobias, H. and Franklin, E.C. (1977). Liver involvement in the syndrome of mixed cryoglobulinemia. Ann. Intern. Med. 87, 287-292
64. Ferri, C., Greco, F. and Longombardo, G. (1991) Hepatitis C virus antibodies in mixed cryoglobulinemia patients. Arthritis Rheum. 34, 1606-1610.
65. Dammacco, F. and Sansonno, D. (1992) Antibodies to hepatitis C virus in essential mixed cryoglobulinemia. Clin. Exp. Immunol. 87: 352-356
66. Pechère-Bertschi, A., Perrin, L., De Saussure, P., Widmann, J.J. and Shifferly, J.A. (1992) Hepatitis C: a possible ethiology for cryoglobulinemia type II. Clin. Exp. Immunol. 89, 419-422.
67. Van Der Pole, C.L., Cuypers, H.T.M., Reesink, H.W., Weiner, A.J., Quan, S., di Nello, R., van Boven, J.H.P., Winkel, I., Mulder-Folkerts, D., Exel-Oehlers, P.J., Schaasberg, W., Leentvaar, R., Kuypers, A., Polito, A., Houghton, M. and Lelie P.N. (1991) Confirmation of hepatitis C virus infection by new four-antigen recombinant immunoblot assay. Lancet 337, 317-319.
68. Szymanski, I.O., Pullman, J.M. and Underwood, J.M. (1994) Electron microscopic and immunochemical studies in a patient with hepatitis C virus infection and mixed cryoglobulinemia type II. Am. J. Clin. Pathol. 102, 278-283.
69. Dammacco, F., Sansonno, D., Cornacchiulo, V., Mennuni, C., Carbone, R., Lauletta, G., lacobelli, A.R. and Rizzi, R. (1993) Hepatitis C virus infection and mixed cryoglobulinemia: a striking association. Int. J. Clin. Lab. Res. 23, 45-49.
70. Ferri, C., La Civita, L., Longombardo, G., Greco, F. and Bombardieri, S. (1993) Hepatitis C virus and mixed cryoglobulinemia. Eur. J. Clin. Invest. 23, 399-405.
71. Sansonno, D., Gesualdo, L., Manno, C., Schena, F.P. and Dammacco, F. (1997) Hepatitis C virus-related proteins in kidney tissue from hepatitis C virus infection patients with cryoglobulinemia membranoproliferative glomerulonephritis. Hepatology 25,1237-1244.
72. Gorevic, P.D. and Frangione, B. (1991) Mixed cryoglobulinemia cross-reactive idiotypes: implications for the relationship of MC to rheumatic and lymphoproliferative diseases. Semin. Hematol. 28, 79-94.
73. Andrews, D.W. and Capra, J.D. (1981) Complete aminoacid sequence of variable domains from two human monoclonal anti-gamma globulins of the WA cross-idiotypic group: suggestion that the J segments are involved in the structural correlate of the idiotype. Proc Natl Acad Sci USA; 78: 3799-3803.
74. Carson, D.A. and Fong, S. (1983) A common idiotope on human rheumatoid factors identified by a hybridoma antibody. Mol. Immunol. 20, 1081-1087.
75. Fong, S., Chen, P.P., Gilbertson, T.A., Weber, J.R., Fox, R.I. and Carson, D.A. (1986) Expression of three cross-reactive idiotypes on rheumatoid factor autoantibodies from patients with autoimmune diseases and seropositive adults. J. Immunol. 137, 122-128.
76. Martin, T., Duffy, S.F., Carson, D.A. and Kipps, T.J. (1992) Evidence for somatic selection of natural autoantibodies. J. Exp.Med. 175, 983-991.
77. Carson, D., Chen, P.P. and Kipps, T.J. (1991) New roles for rheumatoid factor. J. Clin. Invest. 87, 379-383.
78. Theophilopoulos, A.N. and Dixon, F.J. (1990) Immune complexes in human diseases. Am. J. Pathol. 100, 531-594.
79. Roth, D. (1995) Hepatitis C virus: the nephrologist's view. Am. J. Kidney Dis. 25, 3-16.
80. D'Amico, G. and Fornasieri, A. (1995) Cryoglobulinemic glomerulonephritis: a membranoproliferative glomerulonephritis induced by hepatitis C virus. Am. J. Kidney Dis. 25, 361-369.
81. Johnson, R.J., Gretch, D.R., Yamabe, H., Hart, J., Bacchi, C.E., Hartwell, P., Couser, W.G., Corey, L., Wener, M.H., Alpers, C.E. and Willson, R. (1993) Membranoproliferative glomerulonephritis associated with hepatitis C virus infection. N. Engl. J. Med. 328, 465-470.
82. Fornasieri, A., Li, M., Armelloni, S., Pinerolo De Septis, C., Schiaffino, E., Sinico, R.A., Schmid, C. and D'Amico, G. (1993) Glomerulonephritis induced by human IgMK-IgG cryoglobulins in mice. Lab. Invest. 5, 531-540.
83. Tighe, H., Warnatz, K., Brinson, D., Corr, M., Weigle, W.O., Baird, S.M. and Carson, D.A. (1997) Peripheral deletion of rheumatoid factor B cells after activation by IgG. Proc. Natl. Acad. Sci. USA, 94, 646-651.
84. Ferri, C., Caracciolo, F., Zignego, A.L., La Civita, L., Monti, M., Longombardo, G., Lombardini, F., Greco, F., Capochiana, E. and Mazzoni, A. (1994) Hepatitis C virus infection in patients with non-Hodgkin's lymphoma. Br. J. Haematol., 88, 392-394.
85. Silvestri, F., Pipan, C., Barillari, G., Zaja, F., Fanin, R., Infanti, L., Russo, D., Palasca, B., Botta, G. and Baccarani, M. (1996) Prevalence of hepatitis C virus infection in patients with lymphoproliferative disorders. Blood, 87, 4296-4301.
86. Zuckerman, E., Zuckerman, T., Levine, A.M., Douer, D., Gutekunst, K., Mizokami, M., Quian, D., Velankar, M., Nathwani, B.N. and Fong, T.L. (1997). Hepatitis C virus infection in patients with B-cell non-Hodgkin's lymphoma. Ann. Intern. Med. 127, 423-428.
87. De Vita, S., Sacco, C., Sansonno, D., Gloghini, A., Dammacco, F., Crovatto, M., Santini, G.F., Dolcetti, R., Boiocchi, M., Carbone, A. and Zagonel, V. (1997) Characterization of overt B-cell lymphomas in patients with hepatitis C virus infection. Blood, 90, 776-782.
88. Sansonno, D., De Vita, S., Cornacchiulo, V., Carbone, A., Boiocchi, M. and Dammacco, F. (1996) Detection and distribution of hepatitis C virus-related proteins in lymph nodes of patients with type II mixed cryoglobulinemia and neoplastic or non-neoplastic lymphoproliferation. Blood, 88, 4638-4645.
89. Ludwig, C.U., Gencik, M. and Shipman, R. (1993) Multistep transformation in low-grade lymphoproliferative diseases. Ann. Oncol., 4, 825-830.