Is homocysteine a causal and treatable risk factor for vascular diseases of the brain (cognitive impairment and stroke)?

Annals of Neurology

Volumn 51, Issue 3, 2002, Pages 279-281

  Hankey, Graeme J ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

HOMOCYSTEINE;

CARDIOVASCULAR RISK; CEREBROVASCULAR DISEASE; COGNITIVE DEFECT; DRUG BLOOD LEVEL; EDITORIAL; HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RISK FACTOR; STROKE; WHITE MATTER;

CEREBROVASCULAR ACCIDENT; COGNITION DISORDERS; HOMOCYSTEINE; HUMANS; RISK FACTORS;

EID: 0036197959     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.10134     Document Type: Editorial

References (45)

1. Homocysteine, silent brain infarcts and white matter lesions: The Rotterdam Scan study
2. Leuko-araiosis: An ancient term for a new problem
3. Neuropathological assessment of the lesions of significance in vascular dementia
4. Elevated plasma homocysteine levels and risk of silent brain infarction in elderly people
5. Homocysteine and vascular disease
6. Lowering blood homocysteine with folic acid based supplements: Meta-analysis of randomised trials
7. White matter changes on CT and MRI: An overview of visual rating scales
8. Prevalence of cerebral white matter lesions in elderly people: A population based magnetic resonance imaging study: The Rotterdam Scan study
9. Cerebral white matter lesions and atherosderosis in the Rotterdam study
10. Silent MRI infarcts and the risk of future stroke: The cardiovascular health study
11. Cerebral white matter lesions, vascular risk factors, and cognitive function in a population-based study: The Rotterdam study
12. Silent brain infarction on magnetic resonance imaging and neurological abnormalities in community-dwelling older adults: The cardiovascular health study
13. A randomized trial of anticoagulants versus aspirin after cerebral ischaemia of presumed arterial origin
14. Pathogenesis of leukoaraiosis: A review
15. Periventricular lesions in the white matter on magnetic resonance imaging in the elderly: A morphometric correlation with arteriolosclerosis and dilated perivascular spaces
16. Hypertension in the elderly is associated with white matter lesions and cognitive decline
17. Relationship between blood pressure and subcortical lesions in healthy elderly people
18. Evidence for genetic variance in white matter hyperintensity volume in normal elderly male twins
19. Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people: The cardiovascular health study
20. Risk factors for microangiopathy-related cerebral damage in the Austrian stroke prevention study
21. Cerebral white matter lesions and cognitive function: The Rotterdam Scan study
22. Homocyst(e)ine and cardiovascular disease: A critical review of the epidemiologic evidence
23. Blood levels of homocysteine and increased risks of cardiovascular disease: Causal or casual?
24. Homocysteine in cerebral macroangiopathy and microangiopathy
25. Association between high homocyst(e)ine and ischaemic stroke due to large-and small-artery disease but not other etiological subtypes of ischaemic stroke
26. Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in monkeys with hyperhomocyst(e)inemia or hypercholesterolemia
27. Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells
28. Induction of monocyte tissue factor expression by homocysteine: A possible mechanism for thrombosis
29. An alternative view of homocysteine
30. Homocysteine and other sulfhydryl compounds enhance the binding of lipoprotein(a) to fibrin: A potential biochemical link between thrombosis, atherogenesis, and sulfhydryl compound metabolism
31. Influence of folic acid on postprandial endothelial dysfunction
32. Folic acid improves arterial endothelial function in adults with hyperhomocysteinemia
33. Effects of oral folic acid supplementation on endothelial function in familial hypercholesterolemia: A randomized placebo-controlled trial
34. Vitamins and progression of atherosclerosis in hyperhomocyst(e)inaemia
35. 6 on progression of subclinical atherosclerosis: A randomised, placebo-controlled trial
36. Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not vascular disease: The results of a meta-analysis
37. Hyperhomocysteinemia in chronic renal disease
38. Power shortage: Clinical trials testing the "homocysteine hypothesis" against a background of folic acid-fortified cereal grain flour
39. The effect of folic acid fortification on plasma folate and total homocysteine concentrations
40. Reduction of plasma homocyst(e)ine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease
41. Cost-effectiveness of vitamin therapy to lower plasma homocysteine levels for the prevention of coronary heart disease. Effect of grain fortification and beyond
42. Vitamin Intervention for Stroke Prevention (VISP) trial: Rationale and design
43. The VITATOPS (VITAmins To Prevent Stroke) trial: Rationale and design of an international, large, simple, randomised trial of homocysteine-lowering multivitamin therapy in patients with recent transient ischaemic attack or stroke
44. Homocysteine: To screen and treat or to wait and see?
45. Homocyst(e)ine, diet, and cardiovascular diseases: A statement for healthcare professionals from the Nutrition Committee, American Heart Association