Analysis of conditional mutations in the Saccharomyces cerevisiae MLH1 gene in mismatch repair and in meiotic crossing over

Genetics

Volumn 160, Issue 3, 2002, Pages 909-921

  Argueso, Juan Lucas ^a   Smith, Daniel ^a,b   Yi, James ^a,c   Waase, Marc ^a   Sarin, Sumeet ^a   Alani, Eric ^a  

^a Department of Obstetrics Gynecology   (United States)

^b HARVARD UNIVERSITY   (United States)

^c TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; PROTEIN MLH1; PROTEIN MLH3; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; CONTROLLED STUDY; CROSSING OVER; ENZYME ACTIVITY; GENE FUNCTION; GENE INTERACTION; GENE MAPPING; GENE MUTATION; GENE OVEREXPRESSION; MEIOSIS; MISMATCH REPAIR; MOLECULAR RECOGNITION; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; TEMPERATURE SENSITIVITY;

ADENOSINE TRIPHOSPHATASES; BASE PAIR MISMATCH; CROSSING OVER, GENETIC; DNA REPAIR; ESCHERICHIA COLI PROTEINS; EXODEOXYRIBONUCLEASES; FUNGAL PROTEINS; MUTATION; SACCHAROMYCES CEREVISIAE; TEMPERATURE; TWO-HYBRID SYSTEM TECHNIQUES;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0036194879     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (77)

1. Meiotic recombination frequencies are affected by nutritional states in Saccharomyces cerevisiae
2. Interaction between mismatch repair and genetic recombination in Saccharomyces cerevisiae
3. Intermediates of yeast meiotic recombination contain heteroduplex DNA
4. Differential timing and control of noncrossover and crossover recombination during meiosis
5. Exol-dependent mutator mutations: Model system for studying functional interactions in mismatch repair
6. Initiation of methyl-directed mismatch repair
7. Crystal structure and ATPase activity of MutL: Implications for DNA repair and mutagenesis
8. Transformation of MutL by ATP binding and hydrolysis: A switch in DNA mismatch repair
9. Defending genome integrity during DNA replication: A proposal for RecQ family helicases
10. Saccharomyces cerevisiae pol30 (proliferating cell nuclear antigen) mutations impair replication fidelity and mismatch repair
11. Multifunctional yeast high-copy-number shuttle vectors
12. Checkpoint-dependent activation of mutagenic repair in Saccharomyces cerevisiae pol3-01 mutants
13. Repair of specific base pair mismatches formed during meiotic recombination in the yeast Saccharomyces cerevisiae
14. Analysis of a gene conversion gradient at the HIS4 locus in Saccharomyces cerevisiae
15. GHKL, an emergent ATPase/kinase superfamily
16. Exonuclease I of Saccharomyces cerevisiae functions in mitotic recombination in vivo and in vitro
17. The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations
18. Meiotic gene conversion: A signal of the basic recombination event in yeast
19. Mechanisms of meiotic gene conversion or "wanderings on a foreign strand,"
20. The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: A potential eukaryotic reverse gyrase
21. ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair
22. Synthetic enhancement in gene interaction: A genetic tool comes of age
23. ATP-dependent assembly of a ternary complex consisting of a DNA mismatch and the yeast MSH2-MSH6 and MLH1-PMS1 protein complexes
24. The Escherichia coli MutL protein physically interacts with MutH and stimulates the MutH-associated endonuclease activity
25. Evidence for a physical interaction between the Escherichia coli methyl-directed mismatch repair proteins MutL and UvrD
26. Discrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeast
27. Instability of simple sequence DNA in Saccharomyces cerevisiae
28. The conversion gradient at HIS4 of Saccharomyces cerevisiae. I. Heteroduplex rejection and restoration of Mendelian segregation
29. MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repair
30. Macromolecule synthesis and breakdown in relation to sporulation and meiosis in yeast
31. Mlh1 is unique among mismatch repair proteins in its ability to promote crossing-over during meiosis
32. Conditional-lethal mutations that suppress genetic defects in morphogenesis by altering structural proteins
33. Evidence for involvement of yeast proliferating cell nuclear antigen in DNA mismatch repair
34. EXO1 and MSH4 differentially affect crossing-over and segregation
35. Decreased meiotic intergenic recombination and increased meiosis I nondisjunction in exol mutants of Saccharomyces cerevisiae
36. Eukaryotic DNA mismatch repair
37. The BLM helicase interacts with hMLH1 but is not required for DNA mismatch repair
38. The distribution of the numbers of mutants in bacterial populations
39. Fine structure of genes in the ascomycete Ascobolus immersus
40. Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair
41. Mismatch repair in replication fidelity, genetic recombination, and cancer biology
42. Pathway correcting DNA replication errors in Saccharomyces cerevisiae
43. An initiation site for meiotic gene conversion in the yeast Saccharomyces cerevisiae
44. Functional domains of the Saccharomyces cerevisiae Mlh1p and Pms1p DNA mismatch repair proteins and their relevance to human hereditary nonpolyposis colorectal cancer-associated mutations
45. Direct association of Bloom's syndrome gene product with the human mismatch repair protein MLH1
46. Biochemical mutants in the smut fungus Ustilago maydis
47. Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
48. MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeast
49. Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: Evidence for separate mitochondrial and nuclear functions
50. The Saccharomyces cerevisiae ARG4 initiator of meiotic gene conversion and its associated double-strand DNA breaks can be inhibited by transcriptional interference
51. Mutation of a meiosis-specific MutS homolog decreases crossing over but not mismatch correction
52. Origins of gene conversion and reciprocal exchange in Ascobolus
53. Molecular matchmakers
54. The interaction of DNA mismatch repair proteins with human exonuclease I
55. Interaction of MutS and MutL at a DNA mismatch
56. EXO1 and MSH6 are high-copy suppressors of conditional mutations in the MSH2 mismatch repair gene of Saccharomyces cerevisiae
57. Crystal structure of an Hsp90-geldanamycin complex: Targeting of a protein chaperone by an antitumor agent
58. Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair
59. Double-strand breaks at an initiation site for meiotic gene conversion
60. A role for exonuclease I from S. pombe in mutation avoidance and mismatch correction
61. Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2
62. The 3′→5′ exonucleases of DNA polymerases delta and epsilon and the 5′→3′ exonuclease Exo1 have major roles in postreplication mutation avoidance in Saccharomyces cerevisiae
63. Functional studies on the candidate ATPase domains of Saccharomyces cerevisiae MutLα
64. Interactions of Exo1p with components of MutLa in Saccharomyces cerevisiae
65. Exo1 roles for repair of DNA double-strand breaks and meiotic crossing over in Saccharomyces cerevisiae
66. Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis
67. CYS3, a hot spot of meiotic recombination in Saccharomyces cerevisiae: Effects of heterozygosity and mismatch repair functions on gene conversion and recombination intermediates
68. Redundant exonuclease involvement in Escherichia coli methyl-directed mismatch repair
69. Mammalian ras interacts directly with the serine/threonine kinase Raf
70. Functional specificity of MutL homologs in yeast: Evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction
71. Mismatch-specific postmeiotic segregation frequency in yeast suggests a heteroduplex recombination intermediate
72. Crystal structure of an N-terminal fragment of the DNA gyrase B protein
73. Construction of a set of convenient Saccharomyces cerevisiae strains that are isogenic to S288C
74. Protein degradation, meiosis and sporulation in proteinase-deficient mutants of Saccharomyces cerevisiae