A v-SNARE participates in synaptic vesicle formation mediated by the AP3 adaptor complex

Nature Neuroscience

Volumn 1, Issue 7, 1998, Pages 551-556

  Salem, Natalie ^a   Faúndez, Victor ^a   Horng, Jim Tong ^a   Kelly, Regis B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; ALPHA ADAPTIN; BOTULINUM TOXIN; CLATHRIN ASSEMBLY PROTEIN; CLATHRIN ASSEMBLY PROTEIN AP180; MEMBRANE PROTEIN; SYNAPTOBREVIN; TETANUS TOXIN; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ANIMAL; ARTICLE; CELL STRAIN; COATED VESICLE; DRUG ANTAGONISM; DRUG EFFECT; GENE TARGETING; GENETICS; PHYSIOLOGY; RAT; SYNAPSE VESICLE;

ADAPTOR PROTEIN COMPLEX 3; ADAPTOR PROTEIN COMPLEX ALPHA SUBUNITS; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; BOTULINUM TOXINS; COATED VESICLES; GENE TARGETING; MEMBRANE PROTEINS; MONOMERIC CLATHRIN ASSEMBLY PROTEINS; PC12 CELLS; R-SNARE PROTEINS; RATS; SYNAPTIC VESICLES; TETANUS TOXIN;

EID: 0032198135     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/2787     Document Type: Article

References (37)

1. Clift-O'Grady, L., Linstedt, A. D., Lowe, A. W., Grote E. & Kelly R. B. Biogenesis of synaptic vesicle-like structures in a pheochromocytoma cell line PC12. J. Cell Biol. 110, 1693-1703 (1990).
2. Söllner, T et al. SNAP receptors implicated in vesicle targeting and fusion. Nature 362, 318-324 (1993).
3. Grote, E., Hao, J. C., Bennett, M. K. & Kelly, R. B. A targeting signal in VAMP regulating transport to synaptic vesicles. Cell 81, 581-589 (1995).
4. Hao, J. C., Salem, N., Peng, X.-R., Kelly, R. B. & Bennett, M. K. Effects of mutations in vesicle associated membrane protein (VAMP) on the assembly of multimeric synaptic protein complexes. J. Neurosci, 17, 1596-1603 (1996).
5. Broadie, K. et al. Syntaxin and synaptobrevin function downstream of vesicle docking in Drosophila. Neuron 15, 663-673 (1995).
6. Schiavo, G. et al. Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin. Nature 359, 832-835 (1992).
7. Blasi, J. et al. Botulinum neurotoxin C1 blocks neurotransmitter release by means of cleaving HPC-1/syntaxin. EMBO J. 12, 4821-4828 (1993).
8. Desnos, C., Clift-O'Grady, L. & Kelly, R. B. Biogenesis of synaptic vesicles in vitro. J. Cell Biol. 130, 1041-1049 (1995).
9. Odorizzi, G., Cowles, C.R. & Emr, S. D. The AP3 complex: a coat of many colors. Trends Cell Biol. 8, 282-288 (1998).
10. Simpson, F. et al. A novel adaptor protein complex. J. Cell Biol. 133, 749-760 (1996).
11. Dell'Angelica, E. C., Ooi, C. E. & Bonifacino, J. S. Beta3A-adaptin, a subunit of the adaptor-like AP-3. J. Biol. Chem. 272, 15078-15084 (1997).
12. Simpson, F., Peden, A. A., Christopoulou, L. & Robinson, M. S. Characterization of the adaptor-related protein complex, AP-3. J. Cell Biol. 137, 835-845 (1997).
13. Faúndez, V., Horng, J.-T. & Kelly, R. B. A function for the AP-3 coat complex in synaptic vesicle formation. Cell 93, 1-20 (1998).
14. Lichtenstein, Y., Desnos, C., Faündez, V., Kelly, R. B. & Clift-O'Grady L. Vesiculation and sorting from PC12-derived endosomes in vitro. Proc. Natl. Acad. Sci. USA 95, 11223-11228 (1998).
15. McMahon, H. T. et al. Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein. Nature 364, 346-349 (1993).
16. Calakos, N. & Scheller, R. H. Vesicle-associated membrane protein and synaptophysin are associated on the synaptic vesicle. J. Biol. Chem. 269, 24534-24537 (1994).
17. Edelmann, L., Hanson, P. I., Chapman, E. R. & Jahn, R. Synaptobrevin binding to synaptophysin: a potential mechanism for controlling the exocytotic fusion machine. EMBO J. 14, 224-231 (1995).
18. Schmidt, A., Hannah, M. J. & Huttner, W. B. Synaptic-like microvesicles of neuroendocrine cells originate from a novel compartment that is continuous with the plasma membrane and devoid of transferrin receptor. J. Cell Biol. 137, 445-458 (1997).
19. Walch-Solimena, C. et al. The t-SNAREs syntaxin 1 and SNAP-25 are present on organelles that participate in synaptic vesicle recycling. J. Cell Biol. 128, 637-645 (1995).
20. Binz, T. et al. Proteolysis of SNAP-25 by types E and A botulinal neurotoxins. J. Biol. Chem. 269, 1617-1620 (1994).
21. Betz, W. J. & Bewick, G. S. Optical monitoring of transmitter release and synaptic vesicle recycling at the frog neuromuscular junction. J. Physiol. (Lond.) 460, 287-309 (1993).
22. Kinglauf, J., Kavalali, E. T. & Tsien, R. W. Kinetics and regulation of fast endocytosis at hippocampal synapses. Nature 394, 581-585 (1998).
23. Ryan, T. A., Smith, S. J. & Reuter, H. The timing of synaptic vesicle endocytosis. Proc. Natl. Acad. Sci. USA 93, 5567-5571 (1996).
24. Wang, C. & Zucker, R. S. Regulation of synaptic vesicle recycling by calcium and serotonin. Neuron 21, 155-167 (1998).
25. Bennett, M. K. & Scheller, R. H. The molecular machinery for secretion is conserved from yeast to neurons. Proc. Natl. Acad. Sci. USA 90, 2559-2563 (1993).
26. Springer, S. & Schekman, R. Nucleation of COPII vesicular coat complex by endoplasmic reticulum to Golgi vesicle SNAREs. Science 281, 698-700 (1998).
27. Takei, K., Mundigl, O., Daniell, L. & De Camilli, P. The synaptic vesicle cycle: a single vesicle budding step involving clathrin and dynamin. J. Cell Biol. 133, 1237-1250 (1996).
28. Murphy, V. N. & Stevens, C. F. Synaptic vesicles retain their identity through the endocytic cycle. Nature 392, 497-501 (1998).
29. Koenig, J. H. & Ikeda, K. Synaptic vesicles have two distinct recycling pathways. J. Cell Biol. 135, 797-808 (1996).
30. González-Gaitán, M. & Jäckle, H. Role of drosophila α-adaptin in presynaptic vesicle recycling. Cell 88, 767-776 (1997).
31. Miller, T. M. & Heuser, J. E. Endocytosis of synaptic vesicle membrane at the frog neuromuscular junction. J. Cell Biol. 98, 685-698 (1984).
32. Kuromi, H. & Kidokoro, Y. Two distinct pools of synaptic vesicles in single presynaptic boutons in a temperature-sensitive drosophila mutant, shibire. Neuron 20, 917-925 (1998).
33. Kantheti, P. et al. Mutation in AP3 δ in the mocha mouse links endosomal transport to storage deficiency in platelets, melanosomes and synaptic vesicles. Neuron 21, 111-122 (1998).
34. Noebels, J. L. & Sidman, R. L. Persistent hypersynchronization of neocortical neurons in the mocha mutant mouse. J. Neurogenet. 6, 53-56 (1989).
35. Zhang, J. Z., Davietov, B. A., Südhof, T. C. & Anderson, R. G. W. Synaptotagmin I is a high affinity receptor for clathrin AP2: Implications for membrane recycling. Cell 78, 751-760 (1994).
36. Schiavo, G., Stenbeck, G., Rothman J. E. & Söllner, T. H. Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses. Proc. Natl. Acad. Sci. USA 94, 997-1001 (1997).
37. Dell'Angelica, E. C. et al. AP3: an adaptor-like protein complex with ubiquitous expression. EMBO J. 16, 917-928 (1997).