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Toxicologic Pathology

Volumn 30, Issue 1, 2002, Pages 147-156

The Trp53 hemizygous mouse in pharmaceutical development: Points to consider for pathologists

(4) Floyd, Eugenia a Mann, Peter b Long, Gerald c Ochoa, Ricardo d

a PFIZER INC (United States)

b Experimental Pathology Laboratories Inc (United States)

c ELI LILLY AND COMPANY (United States)

d PFIZER GLOBAL RESEARCH AND DEVELOPMENT (United States)

Author keywords

Alternative model; Bioassay; Cancer; Carcinogenicity; Genetically modified; Knockout; p53; Short term assay; Tumor

Indexed keywords

4 CRESIDENE; BENZENE; CARCINOGEN; DNA; GENE PRODUCT; PARA CRESOL; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INCIDENCE; CARCINOGEN TESTING; CELL PROLIFERATION; CONTROLLED STUDY; DECISION MAKING; DIAGNOSTIC ACCURACY; DIAGNOSTIC PROCEDURE; DISEASE MODEL; DOSE RESPONSE; DRUG DEVELOPMENT; DRUG INDUSTRY; FEMALE; HEMIZYGOSITY; HISTOPATHOLOGY; HYPERPLASIA; MALE; MAXIMUM ALLOWABLE CONCENTRATION; MAXIMUM TOLERATED DOSE; MOUSE; NEOPLASM; NONHUMAN; OUTCOMES RESEARCH; PRIORITY JOURNAL; PROCESS DESIGN; SARCOMA; STATISTICAL ANALYSIS; SUBCUTANEOUS TISSUE; SURVIVAL; THYMOMA; TRANSGENIC MOUSE; TRP53 GENE; TUMOR SUPPRESSOR GENE;

ANIMALS; BIOLOGICAL ASSAY; CARCINOGENICITY TESTS; DRUG INDUSTRY; GENES, P53; GENES, TUMOR SUPPRESSOR; MICE; MICE, TRANSGENIC; NEOPLASMS; PATHOLOGY; PHARMACOLOGY;

ANIMALIA; MUS MUSCULUS; RODENTIA;

EID: 0036185657 PISSN: 01926233 EISSN: None Source Type: Journal
DOI: 10.1080/01926230252824860 Document Type: Article

Times cited : (11)

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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.