Transponder-Induced Sarcoma in the Heterozygous p53+/- Mouse

Toxicologic Pathology

Volumn 27, Issue 5, 1999, Pages 519-527

  Blanchard, Kerry T ^a   Barthel, Curt ^a   French, John E ^a   Holden, Henry E ^a   Moretz, Roger ^a   Pack, Franklin D ^a   Tennant, Raymond W ^a   Stoll, Raymond E ^b  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

carcinogenesis models; p53+ mice; radio transmitter; solid state carcinogenesis; subcutaneous sarcoma; Transgenic mice

Indexed keywords

OXYMETHOLONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGEN TESTING; CARCINOGENICITY; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; DYSPLASIA; FEMALE; HETEROZYGOSITY; MALE; MESENCHYME; MOUSE; NONHUMAN; PRIORITY JOURNAL; SARCOMA;

ANABOLIC AGENTS; ANIMALS; CARCINOGENS; DNA, NEOPLASM; FEMALE; GENES, P53; HETEROZYGOTE; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OXYMETHOLONE; POLYPROPYLENES; SARCOMA, EXPERIMENTAL; SKIN; SKIN NEOPLASMS; SURVIVAL ANALYSIS; TRANSDUCERS;

ANIMALIA; MUS MUSCULUS; RODENTIA;

EID: 0032878541     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/019262339902700505     Document Type: Article

References (17)

1. Ball, DJ, Argentieri G., Krause R., Lipinski M., Robison RL, Stoll RE, and Visscher GE (1991). Evaluation of a microchip implant system used for animal identification in rats. Lab Anim. Sci. 41: 185-186.
2. Brand KG, Buoen LC, Johnson KH, and Brand I. (1975). Etiological factors, stages, and the role of the foreign body in foreign body tumorigenesis: A review. Cancer Res. 35: 279-286.
3. Donehower LA, Harvey M., Slagle BL, McArthur MJ, Montgomery Caj, Butel JS, and Bradley A. (1992). Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature 356: 215-221.
4. Harvey M., McArthur MJ, Montgomery Caj, Butel JS, Bradley A., and Donehower LA (1993). Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice. Nat. Genet. 5: 225-229.
5. Johnson KA (1996). Foreign-body tumorigenesis: Sarcomas induced in mice by subcutaneously implanted transponders. Vet. Pathol. 33: 619 (abstract).
6. Kastan MB, Zhan Q., el-Deiry WS, Carrier F., Jacks T., Walsh WV, Plunkett BS, Vogelstein B., and Fornace Ajj (1992). A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71: 587-597.
7. Kemp CJ, Wheldon T., and Balmain A (1994). p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis. Nat. Genet. 8: 66-69.
8. Kuwashima Y., Nemoto N., and Ishikawa T. (1993). Expression of proto-oncogenes and cytoskeletal actin gene in foreign body-induced murine sarcomas. In Vivo 7: 139-142.
9. Leder A., Kuo A., Cardiff RD, Sinn E., and Leder P. (1990). v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: Effects of phorbol esters and retinoic acid. Proc. Natl. Acad. Sci. USA 87: 9178-9182.
10. Mahler JF, Flagler ND, Malarkey DE, Mann PC, Haseman JK, and Eastin W. (1998). Spontaneous and chemically induced proliferative lesions in Tg.AC transgenic and p53-heterozygous mice. Toxicol. Pathol. 26: 501-511.
11. National Cancer Institute (1979). Bioassay of p-Cresidine for Possible Carcinogenicity. Carcinogenesis Technical Report Series No. 142, National Cancer Institute, Bethesda, Maryland.
12. Rao GN and Edmondson J. (1990). Tissue reaction to an implantable identification device in mice. Toxicol. Pathol. 18: 412-416.
13. Robinson D. (1998). The International Life Sciences Institute's role in the evaluation of alternate methodologies for the assessment of carcinogenic risk. Toxicol. Pathol. 26: 474-475.
14. Shi X., Castranova V., Halliwell B., and Vallyathan V. (1998). Reactive oxygen species and silica-induced carcinogenesis. J. Toxicol. Environ. Health B Crit. Rev. 1: 181-197.
15. Tennant RW, French JE, and Spalding JW (1995). Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models. Environ. Health Perspect. 103: 942-950.
16. Tennant RW, Spalding JW, and French JE (1996). Evaluation of transgenic mouse bioassays for identifying carcinogens and non-carcinogens. Mutat. Res. 365: 119-127.
17. Zakut-Houri R., Oren M., Bienz B., Lavie V., Hazum S., and Givol D. (1983). A single gene and a pseudogene for the cellular tumour antigen p53. Nature 306: 594-597.