Evaluation and validation issues in the development of transgenic mouse carcinogenicity bioassays

Environmental Health Perspectives

Volumn 106, Issue SUPPL. 2, 1998, Pages 473-476

  Tennant, Raymond W ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Cancer models; Carcinogen assay validation; Carcinogenicity bioassays; Chemical carcinogens; Environmental carcinogens; Transgenic mouse models

Indexed keywords

CARCINOGEN; ENVIRONMENTAL CHEMICAL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; BIOASSAY; CARCINOGENICITY; CELL CULTURE; CONFERENCE PAPER; DRUG SAFETY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RISK ASSESSMENT; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS;

EID: 0031833937     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.98106473     Document Type: Conference Paper

References (22)

1. Tennant RW, Zeiger E. Genetic toxicology: the current status of methods of carcinogen identification. Environ Health Perspect 100:307-315 (1993).
2. Ashby J. Alternatives to the two-species bioassay For the identification of potential human carcinogens. Human Exp Toxicol 15:183-202 (1996).
3. Tennant RW, Margolin BH, Shelby MD, Zeiger E, Haseman JK, Spalding J, Caspary W, Resnick M, Stasiewicz S, Anderson B et al. Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays. Science 236:933-941 (1987).
4. Haseman JK, Zeiger E, Shelby MD, Margolin BH, Tennant RW. Predicting rodent carcinogenicity from four in vitro genetic toxicity assays: an evaluation of 114 chemicals studied by the National Toxicology Program. J Am Star Assoc 85:964-971 (1990).
5. Shelby M, Witt K. Comparison of results from mouse bone marrow chromosome aberration and micronucleus tests. Environ Mol Mutat 25:302-313 (1995).
6. U.S. Food and Drug Administration. Toxicological Principles for the Safety Assessment of Direct Food Additives and Color Additives Used in Food. Washington:U.S. Government Printing Office, 1993.
7. +/- mouse lymphoma cells. Mutagenesis 5:191-197 (1990).
8. Drinkwater NR, Bennett LM. Genetic control of carcinogenesis in experimental animals. Prog Exp Tumor Res 33:1-20 (1991).
9. Tennant RW. Stratification of rodent carcinogenicity bioassay results to reflect relative human hazard. Mutat Res 286:111-118 (1993).
10. Maronpot RR, Fox T, Malarkey DE, Goldsworthy TL. Mutations in the ras proto-oncogene: clues to etiology and molecular pathogenesis of mouse liver tumors. Toxicology 101:125-156 (1995).
11. Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA, Butel JS Jr, Bradley A. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356:215-221 (1992).
12. Harvey M, McArthur MJ, Montgomery CA, Butel JS Jr, Bradley A, Donehower LA. Spontaneous and carcinogen-induced tumorigenesis in p53 deficient mice. Nat Genet 5:225-229 (1993).
13. Leder A, Kuo A, Cardiff RD, Sinn E, Leder P. v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid. Proc Natl Acad Sci USA 87(23):9178-9182 (1990).
14. Spaldine JW, Momma J, Elwell MR, Tennant RW. Chemically-induced skin carcinogenesis in a transgenic mouse line (Tg.AC) carrying a v-Ha-ras gene. Carcinogenesis 14:1335-1341 (1993).
15. Yamamoto S, Mitsumori K, Kodama Y, Matsunuma N, Manabe S, Okamiya H, Suzuki H, Fukuda T, Sakamaki Y, Sunaga M et al. Rapid induction of more malignant tumors by various genotoxic carcinogens in transgenic mice harboring a human prototype c-Ha-ras gene than in control non-transgenic mice. Carcinogenesis 17:2455-2461 (1966).
16. Tennant RW, French JE, Spalding JW. Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models. Environ Health Perspect 103:942-950 (1995).
17. Lee JM, Abrahamson JL, Kandel R, Donehower LA, Bernstein A. Susceptibility to radiation-carcinogenesis and accumulation of chromosomal breakage in p53 deficient mice. Oncogene 9:3731-3736 (1994).
18. Boutwell RK. Some biological aspects of skin Carcinogenesis. Prog Exp Tumor Res 4:207-250 (1964).
19. Bremmer R, Balmain A. Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity in mouse chromosome 7. Cell 61:407-417 (1990).
20. Hansen LA, Tennant R. Focal transgene expression associated with papilloma development in v-Ha-ras transgenic Tg.AC mice. Mol Carcinogen 9:143-156 (1994).
21. Hansen LA, Spalding JW, French JE, Tennant RW. A transgenic mouse model (Tg.AC) for skin Carcinogenesis: inducible transgene expression as a second critical event. In: Growth Factors and Tumor Promotion: Implications for Risk Assessment (Slaga T, ed). New York:Wiley-Liss, 1995;223-235.
22. [Online]. Available from http://ntp-server.niehs.nih.gov/ Main__ Pages/transgen/TransgenicPage.html